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de Luca XM, Newell F, Kazakoff SH, et al. Using whole-genome sequencing data to derive the homologous recombination deficiency scores. NPJ Breast Cancer. 2020;6:33doi: 10.1038/s41523-020-0172-0.
de Luca, X. M., Newell, F., Kazakoff, S. H., Hartel, G., McCart Reed, A. E., Holmes, O., Xu, Q., Wood, S., Leonard, C., Pearson, J. V., Lakhani, S. R., Waddell, N., Nones, K., & Simpson, P. T. (2020). Using whole-genome sequencing data to derive the homologous recombination deficiency scores. NPJ breast cancer, 633. https://doi.org/10.1038/s41523-020-0172-0
de Luca, Xavier M, et al. "Using whole-genome sequencing data to derive the homologous recombination deficiency scores." NPJ breast cancer vol. 6 (2020): 33. doi: https://doi.org/10.1038/s41523-020-0172-0
de Luca XM, Newell F, Kazakoff SH, Hartel G, McCart Reed AE, Holmes O, Xu Q, Wood S, Leonard C, Pearson JV, Lakhani SR, Waddell N, Nones K, Simpson PT. Using whole-genome sequencing data to derive the homologous recombination deficiency scores. NPJ Breast Cancer. 2020 Aug 07;6:33. doi: 10.1038/s41523-020-0172-0. eCollection 2020. PMID: 32818150; PMCID: PMC7414867.
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NPJ Breast Cancer. 2020 Aug 07;6:33. doi: 10.1038/s41523-020-0172-0. eCollection 2020.

Using whole-genome sequencing data to derive the homologous recombination deficiency scores.

NPJ breast cancer

Xavier M de Luca, Felicity Newell, Stephen H Kazakoff, Gunter Hartel, Amy E McCart Reed, Oliver Holmes, Qinying Xu, Scott Wood, Conrad Leonard, John V Pearson, Sunil R Lakhani, Nicola Waddell, Katia Nones, Peter T Simpson

Affiliations

  1. Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD Australia.
  2. QIMR Berghofer Medical Research Institute, Brisbane, QLD Australia.
  3. Pathology Queensland, Royal Brisbane & Women's Hospital, Brisbane, QLD Australia.

PMID: 32818150 PMCID: PMC7414867 DOI: 10.1038/s41523-020-0172-0

Abstract

The homologous recombination deficiency (HRD) score was developed using whole-genome copy number data derived from arrays as a way to infer deficiency in the homologous recombination DNA damage repair pathway (in particular

© The Author(s) 2020.

Keywords: Breast cancer; Cancer genomics; Medical genomics; Tumour biomarkers

Conflict of interest statement

Competing interestsThe authors declare no competing interests.

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