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Cupaioli FA, Zucca FA, Caporale C, et al. The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects. Prog Neuropsychopharmacol Biol Psychiatry. 2020;106:110059doi: 10.1016/j.pnpbp.2020.110059.
Cupaioli, F. A., Zucca, F. A., Caporale, C., Lesch, K. P., Passamonti, L., & Zecca, L. (2021). The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects. Progress in neuro-psychopharmacology & biological psychiatry, 106110059. https://doi.org/10.1016/j.pnpbp.2020.110059
Cupaioli, Francesca A, et al. "The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects." Progress in neuro-psychopharmacology & biological psychiatry vol. 106 (2021): 110059. doi: https://doi.org/10.1016/j.pnpbp.2020.110059
Cupaioli FA, Zucca FA, Caporale C, Lesch KP, Passamonti L, Zecca L. The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 02;106:110059. doi: 10.1016/j.pnpbp.2020.110059. Epub 2020 Aug 19. PMID: 32822763.
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Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 02;106:110059. doi: 10.1016/j.pnpbp.2020.110059. Epub 2020 Aug 19.

The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects.

Progress in neuro-psychopharmacology & biological psychiatry

Francesca A Cupaioli, Fabio A Zucca, Cinzia Caporale, Klaus-Peter Lesch, Luca Passamonti, Luigi Zecca

Affiliations

  1. Institute of Biomedical Technologies, National Research Council of Italy, Segrate (Milan), Italy.
  2. Institute of Biomedical Technologies, National Research Council of Italy, Unit of Rome, Rome, Italy.
  3. Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany. Electronic address: [email protected].
  4. Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Institute of Bioimaging and Molecular Physiology, National Research Council of Italy, Segrate (Milan), Italy; IRCCS San Camillo Hospital, Venice, Italy. Electronic address: [email protected].
  5. Institute of Biomedical Technologies, National Research Council of Italy, Segrate (Milan), Italy. Electronic address: [email protected].

PMID: 32822763 DOI: 10.1016/j.pnpbp.2020.110059

Abstract

In modern societies, there is a strive to improve the quality of life related to risk of crimes which inevitably requires a better understanding of brain determinants and mediators of aggression. Neurobiology provides powerful tools to achieve this end. Pre-clinical and clinical studies show that changes in regional volumes, metabolism-function and connectivity within specific neural networks are related to aggression. Subregions of prefrontal cortex, insula, amygdala, basal ganglia and hippocampus play a major role within these circuits and have been consistently implicated in biology of aggression. Genetic variations in proteins regulating the synthesis, degradation, and transport of serotonin and dopamine as well as their signal transduction have been found to mediate behavioral variability observed in aggression. Gene-gene and gene-environment interactions represent additional important risk factors for aggressiveness. Considering the social burden of pathological forms of aggression, more basic and translational studies should be conducted to accelerate applications to clinical practice, justice courts, and policy making.

Copyright © 2020 Elsevier Inc. All rights reserved.

Keywords: Aggression; brain regions of aggression; dopamine and serotonin in aggression; genetics of aggression; imaging of aggressive brain

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