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Goswamy D, Irazoqui JE. A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans. Curr Opin Immunol. 2020;68:9-20doi: 10.1016/j.coi.2020.08.002.
Goswamy, D., & Irazoqui, J. E. (2021). A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans. Current opinion in immunology, 689-20. https://doi.org/10.1016/j.coi.2020.08.002
Goswamy, Debanjan, and Irazoqui, Javier E. "A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans." Current opinion in immunology vol. 68 (2021): 9-20. doi: https://doi.org/10.1016/j.coi.2020.08.002
Goswamy D, Irazoqui JE. A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans. Curr Opin Immunol. 2021 Feb;68:9-20. doi: 10.1016/j.coi.2020.08.002. Epub 2020 Sep 06. PMID: 32898751; PMCID: PMC7925333.
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Curr Opin Immunol. 2021 Feb;68:9-20. doi: 10.1016/j.coi.2020.08.002. Epub 2020 Sep 06.

A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans.

Current opinion in immunology

Debanjan Goswamy, Javier E Irazoqui

Affiliations

  1. Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, United States; Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01605, United States.
  2. Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, United States; Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01605, United States. Electronic address: [email protected].

PMID: 32898751 PMCID: PMC7925333 DOI: 10.1016/j.coi.2020.08.002

Abstract

During intestinal infection, microbes induce ROS by various mechanisms in C. elegans. ROS can have beneficial roles, acting as antimicrobials and as signaling molecules that activate cytoprotective pathways. Failure to maintain appropriate levels of ROS causes oxidative stress and cellular damage. This review uses the Damage Response Framework to interpret several recent observations on the relationships between infection, host response, and host damage, with a focus on mechanisms mediated by ROS. We propose a unifying hypothesis that ROS drive a collapse in proteostasis in infected C. elegans, which results in death during unresolved infection. Because the signaling pathways highlighted here are conserved in mammals, the mentioned and future studies can provide new tools of hypothesis generation in human health and disease.

Copyright © 2020 Elsevier Ltd. All rights reserved.

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