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Bishop E, Ismailova A, Dimeloe SK, et al. Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory. JBMR Plus. 2020;doi: 10.1002/jbm4.10405.
Bishop, E., Ismailova, A., Dimeloe, S. K., Hewison, M., & White, J. H. (2020). Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory. JBMR plus, . https://doi.org/10.1002/jbm4.10405
Bishop, Emma, et al. "Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory." JBMR plus vol. (2020). doi: https://doi.org/10.1002/jbm4.10405
Bishop E, Ismailova A, Dimeloe SK, Hewison M, White JH. Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory. JBMR Plus. 2020 Aug 22; doi: 10.1002/jbm4.10405. Epub 2020 Aug 22. PMID: 32904944; PMCID: PMC7461279.
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JBMR Plus. 2020 Aug 22; doi: 10.1002/jbm4.10405. Epub 2020 Aug 22.

Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory.

JBMR plus

Emma Bishop, Aiten Ismailova, Sarah K Dimeloe, Martin Hewison, John H White

Affiliations

  1. Institute of Immunology and Immunotherapy University of Birmingham Birmingham UK.
  2. Department of Physiology McGill University Montreal Qc Canada.
  3. Metabolism and Systems Research University of Birmingham Birmingham UK.
  4. Department of Medicine McGill University Montreal Qc Canada.

PMID: 32904944 PMCID: PMC7461279 DOI: 10.1002/jbm4.10405

Abstract

Regulation of immune function continues to be one of the most well recognised extra-skeletal actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells such as macrophages could actively metabolise precursor 25-hydroxyvitamin D (25D) to active 1,25-dihydroxyvitamin D (1,25D). Parallel observation that activated cells from the immune system expressed the intracellular vitamin D receptor (VDR) for 1,25D suggested a potential role for vitamin D as a localised endogenous modulator of immune function. Subsequent studies have expanded our understanding of how vitamin D exerts effects on both the innate and adaptive arms of the immune system. At an innate level, intracrine synthesis of 1,25D by macrophages and dendritic cells (DC) stimulates expression of antimicrobial proteins such as cathelicidin, as well as lowering intracellular iron concentrations via suppression of hepcidin. By potently enhancing autophagy, 1,25D may also play an important role in combatting intracellular pathogens such as

This article is protected by copyright. All rights reserved.

Keywords: NOD2; Th1; Th17; Treg; antibacterial; autophagy; cathelicidin; hepcidin; inflammation; vitamin D; β‐defensin 2

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