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Feng R, Ullah M, Chen K, et al. Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension. J Extracell Vesicles. 2020;9(1):1783869doi: 10.1080/20013078.2020.1783869.
Feng, R., Ullah, M., Chen, K., Ali, Q., Lin, Y., & Sun, Z. (2020). Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension. Journal of extracellular vesicles, 9(1), 1783869. https://doi.org/10.1080/20013078.2020.1783869
Feng, Rui, et al. "Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension." Journal of extracellular vesicles vol. 9,1 (2020): 1783869. doi: https://doi.org/10.1080/20013078.2020.1783869
Feng R, Ullah M, Chen K, Ali Q, Lin Y, Sun Z. Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension. J Extracell Vesicles. 2020 Jun 24;9(1):1783869. doi: 10.1080/20013078.2020.1783869. PMID: 32939234; PMCID: PMC7480600.
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J Extracell Vesicles. 2020 Jun 24;9(1):1783869. doi: 10.1080/20013078.2020.1783869.

Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension.

Journal of extracellular vesicles

Rui Feng, Mujib Ullah, Kai Chen, Quaisar Ali, Yi Lin, Zhongjie Sun

Affiliations

  1. Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  2. Department of Physiology, College of Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA.

PMID: 32939234 PMCID: PMC7480600 DOI: 10.1080/20013078.2020.1783869

Abstract

The prevalence of arterial stiffness and hypertension increases with age. This study investigates the effect of induced pluripotent mesenchymal stem cell-derived extracellular vesicles (EVs) on ageing-associated arterial stiffness and hypertension. EVs were collected and purified from induced pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs). Young and old male C57BL/6 mice were used. Mice in the EVs group were injected

ABBREVIATIONS: EV: Extracellular vesicles; iPS: induced pluripotent stem cell; MSC: mesenchymal stem cell; AMPKα: AMP activated protein kinase α; eNOS: endothelial nitric oxide synthase; Sirt1: sirtuin 1; JNC7: Seventh Report of the Joint National Committee; CVD: cardiovascular disease; PWV: pulse wave velocity; BP: blood pressure; SNP: sodium nitroprusside.

© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

Keywords: AMPK; Extracellular vesicles; SIRT1; arterial stiffness; hypertension; stem cell

Conflict of interest statement

No potential conflict of interest was reported by the author(s).

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