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Mibielli MAN, Nunes CP, Goldberg H, et al. Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study. J Pain Res. 2020;13:2531-2541doi: 10.2147/JPR.S277024.
Mibielli, M. A. N., Nunes, C. P., Goldberg, H., Buchman, L., Oliveira, L., Mezitis, S. G. E., Wajnzstajn, F., Kaufman, R., Nigri, R., Cytrynbaum, N., Cunha, K. S., Santos, A., Goldberg, S. W., Platenik, N. C., Rzetelna, H., Futuro, D. B., Da Fonseca, A. S., & Geller, M. (2020). Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study. Journal of pain research, 132531-2541. https://doi.org/10.2147/JPR.S277024
Mibielli, Marco Antonio Naslausky, et al. "Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study." Journal of pain research vol. 13 (2020): 2531-2541. doi: https://doi.org/10.2147/JPR.S277024
Mibielli MAN, Nunes CP, Goldberg H, Buchman L, Oliveira L, Mezitis SGE, Wajnzstajn F, Kaufman R, Nigri R, Cytrynbaum N, Cunha KS, Santos A, Goldberg SW, Platenik NC, Rzetelna H, Futuro DB, Da Fonseca AS, Geller M. Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study. J Pain Res. 2020 Oct 13;13:2531-2541. doi: 10.2147/JPR.S277024. eCollection 2020. PMID: 33116795; PMCID: PMC7568635.
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J Pain Res. 2020 Oct 13;13:2531-2541. doi: 10.2147/JPR.S277024. eCollection 2020.

Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study.

Journal of pain research

Marco Antonio Naslausky Mibielli, Carlos Pereira Nunes, Henrique Goldberg, Luiz Buchman, Lisa Oliveira, Spyros G E Mezitis, Fernanda Wajnzstajn, Renato Kaufman, Rafael Nigri, Natasha Cytrynbaum, Karin Soares Cunha, Alessandra Santos, Stephanie Wrobel Goldberg, Natália Carvalho Platenik, Helio Rzetelna, Daniel Bertoluci Futuro, Adenilson de Souza Da Fonseca, Mauro Geller

Affiliations

  1. UNIFESO Medical School, Teresópolis, Brazil.
  2. UERJ Medical School, Rio De Janeiro, Brazil.
  3. Instituto De Pós-Graduação Médica Carlos Chagas (ICC), Rio De Janeiro, Brazil.
  4. Federal University of Rio De Janeiro (UFRJ), Rio De Janeiro, Brazil.
  5. New York-Presbyterian Hospital/Weill-Cornell Medical Center, New York, NY, USA.
  6. Neurology Department, UConn Health, Farmington, CT, USA.
  7. Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
  8. Pathology Department, Universidade Federal Fluminense (UFF) Medical School, Niterói, Brazil.
  9. Tufts Medical Center, Boston, MA, USA.
  10. Santa Casa Da Misericórdia Do Rio De Janeiro, Rio De Janeiro, Brazil.

PMID: 33116795 PMCID: PMC7568635 DOI: 10.2147/JPR.S277024

Abstract

PURPOSE: We report the results of low back pain treatment using a combination of nucleotides, uridine (UTP), cytidine (CMP) and vitamin B

PATIENTS AND METHODS: Randomized, double-blind, controlled trial, of a 60-day oral treatment: Group A (n=317) receiving nucleotides+B

RESULTS: Seventy-five (24%) and 105 (33%) subjects (

CONCLUSION: Treatment with nucleotides+B

© 2020 Mibielli et al.

Keywords: cytidine; low back pain; uridine; vitamin B1; vitamin B12; vitamin B6

Conflict of interest statement

This study was sponsored by Laboratório Gross S.A. (Rio de Janeiro, RJ, Brazil). Fernanda Wajnzstajn reports being a PI for a clinical trial sponsored by Alnylam, outside the submitted work. The autho

References

  1. Trends Pharmacol Sci. 1997 Oct;18(10):387-92 - PubMed
  2. Ann Intern Med. 2017 Apr 4;166(7):480-492 - PubMed
  3. Acta Histochem Suppl. 1992;42:333-9 - PubMed
  4. Arzneimittelforschung. 1992 Sep;42(9):1075-8 - PubMed
  5. Ann Intern Med. 2014 Jun 3;160(11):ITC6-1 - PubMed
  6. J Pain Res. 2017 Feb 15;10:397-404 - PubMed
  7. Proc West Pharmacol Soc. 2004;47:92-4 - PubMed
  8. Med Clin North Am. 2014 Jul;98(4):777-89, xii - PubMed
  9. Brain Res. 2006 May 9;1088(1):83-92 - PubMed
  10. Biochemistry. 1991 Aug 13;30(32):8045-51 - PubMed
  11. Med Clin North Am. 2014 May;98(3):405-28 - PubMed
  12. Clin Toxicol (Phila). 2006;44 Suppl 1:17-28 - PubMed
  13. Braz J Med Biol Res. 2001 Feb;34(2):203-10 - PubMed
  14. Best Pract Res Clin Rheumatol. 2010 Dec;24(6):769-81 - PubMed
  15. Occup Environ Med. 2005 Dec;62(12):851-60 - PubMed
  16. BMJ. 2006 Jun 17;332(7555):1430-4 - PubMed
  17. CNS Neurosci Ther. 2020 Jan;26(1):5-13 - PubMed
  18. Lancet. 2017 Feb 18;389(10070):736-747 - PubMed
  19. Proc Natl Acad Sci U S A. 1976 May;73(5):1494-8 - PubMed
  20. J Neurol Sci. 1994 Apr;122(2):140-3 - PubMed
  21. Pain. 2011 Aug;152(8):1899-908 - PubMed
  22. Methods Find Exp Clin Pharmacol. 2008 Jul-Aug;30(6):431-41 - PubMed
  23. Spine (Phila Pa 1976). 1983 Mar;8(2):141-4 - PubMed
  24. Intern Med. 1999 Jun;38(6):472-5 - PubMed
  25. Clin Neurol Neurosurg. 1992;94(2):105-11 - PubMed
  26. Eur Rev Med Pharmacol Sci. 2000 May-Jun;4(3):53-8 - PubMed

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