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Yang Y, Klionsky DJ. A novel reticulophagy receptor, Epr1: a bridge between the phagophore protein Atg8 and ER transmembrane VAP proteins. Autophagy. 2020;17(3):597-598doi: 10.1080/15548627.2020.1837457.
Yang, Y., & Klionsky, D. J. (2021). A novel reticulophagy receptor, Epr1: a bridge between the phagophore protein Atg8 and ER transmembrane VAP proteins. Autophagy, 17(3), 597-598. https://doi.org/10.1080/15548627.2020.1837457
Yang, Ying, and Klionsky, Daniel J. "A novel reticulophagy receptor, Epr1: a bridge between the phagophore protein Atg8 and ER transmembrane VAP proteins." Autophagy vol. 17,3 (2021): 597-598. doi: https://doi.org/10.1080/15548627.2020.1837457
Yang Y, Klionsky DJ. A novel reticulophagy receptor, Epr1: a bridge between the phagophore protein Atg8 and ER transmembrane VAP proteins. Autophagy. 2021 Mar;17(3):597-598. doi: 10.1080/15548627.2020.1837457. Epub 2020 Oct 29. PMID: 33121335; PMCID: PMC8032234.
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Autophagy. 2021 Mar;17(3):597-598. doi: 10.1080/15548627.2020.1837457. Epub 2020 Oct 29.

A novel reticulophagy receptor, Epr1: a bridge between the phagophore protein Atg8 and ER transmembrane VAP proteins.

Autophagy

Ying Yang, Daniel J Klionsky

Affiliations

  1. Life Sciences Institute, and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

PMID: 33121335 PMCID: PMC8032234 DOI: 10.1080/15548627.2020.1837457

Abstract

Reticulophagy, a type of selective autophagy that specifically targets and degrades parts of the endoplasmic reticulum (ER) network (sheets or tubules), plays a crucial role in the responses to ER stress. The selectivity of the ER cargo recognition relies on the unique reticulophagy receptors, which tether and deliver cargos to phagophores, the precursors to autophagosomes. Various integral membrane proteins have been well characterized as reticulophagy receptors, including Atg39, Atg40, RETREG1/FAM134B, SEC62, RTN3L, CCPG1, TEX264, and ATL3, in both yeast and mammals in the past five years. In a recent paper, Zhao et al. discovered in fission yeast a novel reticulophagy receptor, Epr1, which bridges the ER and phagophore by binding to Atg8 and VAPs, a mechanism different from the aforementioned reticulophagy receptors.

Keywords: Autophagy; endoplasmic reticulum; stress; vacuole; yeast

References

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