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Lu G, Zhou B, He Y, et al. Novel genetic variants of . Am J Cancer Res. 2020;10(10):3382-3394
Lu, G., Zhou, B., He, Y., Liu, H., Luo, S., Amos, C. I., Lee, J. E., Yang, K., Qureshi, A., Han, J., & Wei, Q. (2020). Novel genetic variants of . American journal of cancer research, 10(10), 3382-3394.
Lu, Guiqing, et al. "Novel genetic variants of ." American journal of cancer research vol. 10,10 (2020): 3382-3394.
Lu G, Zhou B, He Y, Liu H, Luo S, Amos CI, Lee JE, Yang K, Qureshi A, Han J, Wei Q. Novel genetic variants of . Am J Cancer Res. 2020 Oct 01;10(10):3382-3394. eCollection 2020. PMID: 33163277; PMCID: PMC7642651.
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Am J Cancer Res. 2020 Oct 01;10(10):3382-3394. eCollection 2020.

Novel genetic variants of .

American journal of cancer research

Guiqing Lu, Bingrong Zhou, Yuanmin He, Hongliang Liu, Sheng Luo, Christopher I Amos, Jeffrey E Lee, Keming Yang, Abrar Qureshi, Jiali Han, Qingyi Wei

Affiliations

  1. Department of Dermatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University Nanjing 210019, Jiangsu, China.
  2. Duke Cancer Institute, Duke University Medical Center Durham, NC 27710, USA.
  3. Department of Population Health Sciences, Duke University School of Medicine Durham, NC 27710, USA.
  4. Department of Biostatistics and Bioinformatics, Duke University School of Medicine Durham, NC 27710, USA.
  5. Institute for Clinical and Translational Research, Baylor College of Medicine Houston, TX 77030, USA.
  6. Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center Houston, TX 77030, USA.
  7. Department of Nutrition, Harvard T.H. Chan School of Public Health Boston, MA, USA.
  8. Department of Dermatology, Warren Alpert Medical School, Brown University Providence, RI 02903, USA.
  9. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital Boston, MA 02115, USA.
  10. Department of Epidemiology, Fairbanks School of Public Health, Indiana University Indianapolis, IN 46202, USA.
  11. Department of Medicine, Duke University School of Medicine Durham, NC 27710, USA.

PMID: 33163277 PMCID: PMC7642651

Abstract

Endosomes regulate cell polarity, adhesion, signaling, immunity, and tumor progression, which may influence cancer outcomes. Here we evaluated associations between 36,068 genetic variants of 228 endosome-related pathway genes and cutaneous melanoma disease-specific survival (CMSS) using genotyping data from two previously published genome-wide association studies. The discovery dataset included 858 CM patients with 95 deaths from The University of Texas MD Anderson Cancer Center, and the replication dataset included 409 CM patients with 48 deaths from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). In multivariate Cox proportional hazards regression analysis, we found that two novel SNPs (

AJCR Copyright © 2020.

Keywords: Genome-wide association study; cutaneous melanoma-specific survival; endosome pathway; immunity; single-nucleotide polymorphism

Conflict of interest statement

None.

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