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Front Aging Neurosci. 2020 Oct 20;12:585218. doi: 10.3389/fnagi.2020.585218. eCollection 2020.

Detection of Cerebrovascular Loss in the Normal Aging C57BL/6 Mouse Brain Using .

Frontiers in aging neuroscience

Lindsay K Hill, Dung Minh Hoang, Luis A Chiriboga, Thomas Wisniewski, Martin J Sadowski, Youssef Z Wadghiri

Affiliations

  1. Department of Chemical and Biomolecular Engineering, NYU Tandon School of Engineering, Brooklyn, NY, United States.
  2. Department of Radiology, Center for Advanced Imaging Innovation and Research (CAI2R), NYU Grossman School of Medicine, New York, NY, United States.
  3. Department of Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging, NYU Grossman School of Medicine, New York, NY, United States.
  4. Department of Biomedical Engineering, SUNY Downstate Medical Center, Brooklyn, NY, United States.
  5. Department of Pathology, NYU Grossman School of Medicine, New York, NY, United States.
  6. Department of Neurology, NYU Grossman School of Medicine, New York, NY, United States.
  7. Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, United States.
  8. Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, United States.

PMID: 33192479 PMCID: PMC7606987 DOI: 10.3389/fnagi.2020.585218

Abstract

Microvascular rarefaction, or the decrease in vascular density, has been described in the cerebrovasculature of aging humans, rats, and, more recently, mice in the presence and absence of age-dependent diseases. Given the wide use of mice in modeling age-dependent human diseases of the cerebrovasculature, visualization, and quantification of the global murine cerebrovasculature is necessary for establishing the baseline changes that occur with aging. To provide

Copyright © 2020 Hill, Hoang, Chiriboga, Wisniewski, Sadowski and Wadghiri.

Keywords: MRI; blood pool agent; cerebral blood volume (CBV); magnetic resonance (MR) angiography; mouse brain aging; rarefaction

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