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Autophagy. 2021 Nov;17(11):3297-3305. doi: 10.1080/15548627.2020.1853382. Epub 2020 Dec 15.

Selective autophagy: the rise of the zebrafish model.

Autophagy

Devesh C Pant, Taras Y Nazarko

Affiliations

  1. Department of Biology, Georgia State University, Atlanta, GA, USA.

PMID: 33228439 PMCID: PMC8632090 DOI: 10.1080/15548627.2020.1853382

Abstract

Selective autophagy is a specific elimination of certain intracellular substrates by autophagic pathways. The most studied macroautophagy pathway involves tagging and recognition of a specific cargo by the autophagic membrane (phagophore) followed by the complete sequestration of targeted cargo from the cytosol by the double-membrane vesicle, autophagosome. Until recently, the knowledge about selective macroautophagy was minimal, but now there is a panoply of links elucidating how phagophores engulf their substrates selectively. The studies of selective autophagy processes have further stressed the importance of using the

Keywords: Aggrephagy; lipophagy; mitophagy; selective autophagy; xenophagy; zebrafish

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