Autophagy. 2021 Nov;17(11):3297-3305. doi: 10.1080/15548627.2020.1853382. Epub 2020 Dec 15.
Autophagy
Devesh C Pant, Taras Y Nazarko
PMID: 33228439 PMCID: PMC8632090 DOI: 10.1080/15548627.2020.1853382
Selective autophagy is a specific elimination of certain intracellular substrates by autophagic pathways. The most studied macroautophagy pathway involves tagging and recognition of a specific cargo by the autophagic membrane (phagophore) followed by the complete sequestration of targeted cargo from the cytosol by the double-membrane vesicle, autophagosome. Until recently, the knowledge about selective macroautophagy was minimal, but now there is a panoply of links elucidating how phagophores engulf their substrates selectively. The studies of selective autophagy processes have further stressed the importance of using the
Keywords: Aggrephagy; lipophagy; mitophagy; selective autophagy; xenophagy; zebrafish