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Liu C, Ke P, Zhang J, et al. Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A. Front Physiol. 2020;11:574030doi: 10.3389/fphys.2020.574030.
Liu, C., Ke, P., Zhang, J., Zhang, X., & Chen, X. (2020). Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A. Frontiers in physiology, 11574030. https://doi.org/10.3389/fphys.2020.574030
Liu, Chong, et al. "Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A." Frontiers in physiology vol. 11 (2020): 574030. doi: https://doi.org/10.3389/fphys.2020.574030
Liu C, Ke P, Zhang J, Zhang X, Chen X. Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A. Front Physiol. 2020 Nov 25;11:574030. doi: 10.3389/fphys.2020.574030. eCollection 2020. PMID: 33324237; PMCID: PMC7723848.
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Front Physiol. 2020 Nov 25;11:574030. doi: 10.3389/fphys.2020.574030. eCollection 2020.

Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A.

Frontiers in physiology

Chong Liu, Ping Ke, Jingjing Zhang, Xiaoying Zhang, Xiongwen Chen

Affiliations

  1. Department of Pharmacology, Second Military Medical University, Shanghai, China.
  2. Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA, United States.

PMID: 33324237 PMCID: PMC7723848 DOI: 10.3389/fphys.2020.574030

Abstract

The protein kinase enzyme family plays a pivotal role in almost every aspect of cellular function, including cellular metabolism, division, proliferation, transcription, movement, and survival. Protein kinase A (PKA), whose activation is triggered by cyclic adenosine monophosphate (cAMP), is widely distributed in various systems and tissues throughout the body and highly related to pathogenesis and progression of various kinds of diseases. The inhibition of PKA activation is essential for the study of PKA functions. Protein kinase inhibitor peptide (PKI) is a potent, heat-stable, and specific PKA inhibitor. It has been demonstrated that PKI can block PKA-mediated phosphorylase activation. Since then, researchers have a lot of knowledge about PKI. PKI is considered to be the most effective and specific method to inhibit PKA and is widely used in related research. In this review, we will first introduce the knowledge on the activation of PKA and mechanisms related on the inhibitory effects of PKI on PKA. Then, we will compare PKI-mediated PKA inhibition vs. several popular methods of PKA inhibition.

Copyright © 2020 Liu, Ke, Zhang, Zhang and Chen.

Keywords: H89; cyclic adenosine monophosphate; protein kinase A; protein kinase A inhibition; protein kinase inhibitor peptide

References

  1. Biochem J. 2000 Jul 15;349(Pt 2):403-7 - PubMed
  2. Biochim Biophys Acta Bioenerg. 2018 Sep;1859(9):868-877 - PubMed
  3. Biochemistry. 1964 Aug;3:1040-4 - PubMed
  4. Endocr Relat Cancer. 2009 Sep;16(3):773-93 - PubMed
  5. Mol Cell. 2016 May 5;62(3):371-384 - PubMed
  6. Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1560-8 - PubMed
  7. Annu Rev Biochem. 1990;59:971-1005 - PubMed
  8. Science. 2002 Dec 6;298(5600):1912-34 - PubMed
  9. Heart Vessels. 2014 Sep;29(5):718-22 - PubMed
  10. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7959-E7968 - PubMed
  11. J Biol Chem. 1990 Mar 25;265(9):5267-72 - PubMed
  12. Int J Biochem Cell Biol. 2011 Sep;43(9):1402-11 - PubMed
  13. Circ Res. 2003 Apr 4;92(6):609-16 - PubMed
  14. Biochem Biophys Res Commun. 1997 Mar 27;232(3):648-51 - PubMed
  15. Mol Cell Biochem. 1993 Nov;127-128:179-86 - PubMed
  16. J Biol Chem. 1996 Oct 18;271(42):26157-64 - PubMed
  17. Int J Cancer. 1997 Jul 17;72(2):340-4 - PubMed
  18. Biochemistry. 1992 Feb 18;31(6):1728-34 - PubMed
  19. Neurosci Lett. 2011 Jul 8;498(2):158-61 - PubMed
  20. Hum Reprod. 2016 Apr;31(4):832-43 - PubMed
  21. Invest Ophthalmol Vis Sci. 1997 Mar;38(3):610-9 - PubMed
  22. Cell Signal. 2017 Sep;37:1-11 - PubMed
  23. J Neurosci. 2009 Oct 21;29(42):13274-82 - PubMed
  24. Cancer Res. 2016 Sep 15;76(18):5266-76 - PubMed
  25. Biochem Soc Trans. 2020 Feb 28;48(1):39-49 - PubMed
  26. Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10414-10419 - PubMed
  27. Cell Signal. 2015 Dec;27(12):2474-87 - PubMed
  28. Cell Cycle. 2014;13(20):3292-301 - PubMed
  29. J Biol Chem. 2006 Aug 25;281(34):24365-74 - PubMed
  30. Mol Endocrinol. 1992 Dec;6(12):2114-22 - PubMed
  31. Cell Signal. 2017 Dec;40:143-155 - PubMed
  32. Cell. 2004 Jun 11;117(6):699-711 - PubMed
  33. Neuropeptides. 2006 Feb;40(1):23-34 - PubMed
  34. J Biol Chem. 1971 Apr 10;246(7):1977-85 - PubMed
  35. Eur J Pharmacol. 2013 Aug 15;714(1-3):170-7 - PubMed
  36. Protein Sci. 1995 Mar;4(3):405-15 - PubMed
  37. FEBS Lett. 2005 Jan 3;579(1):251-8 - PubMed
  38. Mol Med Rep. 2018 Jun;17(6):8530-8535 - PubMed
  39. Mol Biol Cell. 1993 Oct;4(10):993-1002 - PubMed
  40. Int J Mol Sci. 2014 Dec 24;16(1):218-29 - PubMed
  41. Invest Ophthalmol Vis Sci. 2013 Apr 30;54(4):3052-7 - PubMed
  42. J Neurochem. 2004 Nov;91(3):657-66 - PubMed
  43. Apoptosis. 2006 Aug;11(8):1263-73 - PubMed
  44. Circ Res. 2013 Feb 1;112(3):498-509 - PubMed
  45. Neuropharmacology. 2005 Apr;48(5):648-57 - PubMed
  46. J Biol Chem. 2003 Aug 8;278(32):29819-23 - PubMed
  47. J Biol Chem. 1958 Jun;232(2):1077-91 - PubMed
  48. J Biol Chem. 1977 Jul 25;252(14):4888-94 - PubMed
  49. J Neurosci. 2001 Aug 15;21(16):6000-7 - PubMed
  50. Curr Opin Neurobiol. 1997 Oct;7(5):713-9 - PubMed
  51. Cardiovasc Drug Rev. 2006 Fall-Winter;24(3-4):261-74 - PubMed
  52. Elife. 2013 Nov 05;2:e01319 - PubMed
  53. Pharmacol Rev. 1966 Mar;18(1):145-61 - PubMed
  54. Mol Endocrinol. 1990 Aug;4(8):1087-94 - PubMed
  55. Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H519-28 - PubMed
  56. Pharmacol Ther. 2018 May;185:99-121 - PubMed
  57. Sci Signal. 2008 Jun 03;1(22):re4 - PubMed
  58. J Gen Physiol. 2008 Aug;132(2):279-94 - PubMed
  59. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6497-E6506 - PubMed
  60. Chem Biol. 2007 Sep;14(9):1031-42 - PubMed
  61. Pharmacol Res. 2015 Oct;100:1-23 - PubMed
  62. Nat Cell Biol. 2000 Sep;2(9):593-600 - PubMed
  63. Science. 1999 Jul 2;285(5424):93-6 - PubMed
  64. Gen Comp Endocrinol. 2013 Jan 15;181:88-97 - PubMed
  65. Eur J Endocrinol. 2005 Apr;152(4):671-7 - PubMed
  66. Elife. 2020 Apr 27;9: - PubMed
  67. Biochem Soc Trans. 2003 Feb;31(Pt 1):87-9 - PubMed
  68. Surgery. 2003 Aug;134(2):197-205 - PubMed
  69. J Endocrinol. 2020 Sep;246(3):R51-R64 - PubMed
  70. J Biol Chem. 1958 Jun;232(2):1065-76 - PubMed
  71. J Cell Sci. 2013 Dec 1;126(Pt 23):5357-68 - PubMed
  72. J Biol Chem. 1999 Mar 5;274(10):6381-7 - PubMed
  73. J Cell Mol Med. 2019 Nov;23(11):7170-7179 - PubMed
  74. Exp Cell Res. 2000 Apr 10;256(1):213-24 - PubMed
  75. J Biol Chem. 1972 Oct 25;247(20):6637-42 - PubMed
  76. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2517-28 - PubMed
  77. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):109-19 - PubMed
  78. Biochemistry. 1977 Jul 12;16(14):3080-6 - PubMed
  79. Biochim Biophys Acta. 1956 Apr;20(1):150-7 - PubMed
  80. Nature. 1998 Feb 19;391(6669):806-11 - PubMed
  81. FEBS Lett. 1999 Dec 31;464(3):174-8 - PubMed
  82. Cell Chem Biol. 2019 Jun 20;26(6):885-891.e4 - PubMed
  83. Brain Behav Immun. 2016 Nov;58:118-129 - PubMed
  84. Cell. 1989 Nov 17;59(4):675-80 - PubMed
  85. Nat Rev Mol Cell Biol. 2012 Oct;13(10):646-58 - PubMed
  86. Eur J Biochem. 1984 Jul 16;142(2):255-60 - PubMed
  87. ACS Synth Biol. 2014 Nov 21;3(11):788-95 - PubMed
  88. J Biol Chem. 1958 Mar;231(1):73-83 - PubMed
  89. Science. 2017 Jun 23;356(6344):1288-1293 - PubMed
  90. J Neurosci. 1998 Mar 15;18(6):2017-27 - PubMed
  91. Biochem J. 2008 Jul 1;413(1):93-101 - PubMed
  92. Curr Opin Biotechnol. 1994 Oct;5(5):516-20 - PubMed
  93. PLoS One. 2012;7(11):e49512 - PubMed
  94. J Neurochem. 2008 Jan;104(1):74-88 - PubMed
  95. J Biol Chem. 1965 Mar;240:982-5 - PubMed
  96. J Cell Physiol. 2017 May;232(5):922-927 - PubMed
  97. Mol Pharmacol. 2009 Dec;76(6):1290-301 - PubMed
  98. Biochem Biophys Res Commun. 2004 Apr 9;316(3):612-7 - PubMed
  99. FASEB J. 2020 Oct;34(10):13900-13917 - PubMed
  100. Molecules. 2019 Apr 20;24(8): - PubMed
  101. Circ Res. 2002 Sep 20;91(6):517-24 - PubMed
  102. Circ Res. 2019 Jun 7;124(12):1760-1777 - PubMed
  103. Eur J Cell Biol. 2006 Jul;85(7):627-33 - PubMed
  104. J Biol Chem. 1994 Jan 28;269(4):2676-86 - PubMed
  105. Anal Bioanal Chem. 2005 Feb;381(3):647-55 - PubMed
  106. Neural Plast. 2015;2015:374520 - PubMed
  107. Curr Opin Genet Dev. 1992 Apr;2(2):199-204 - PubMed
  108. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7786-91 - PubMed
  109. J Biol Chem. 2011 Sep 23;286(38):33134-40 - PubMed
  110. J Biol Chem. 1980 Feb 25;255(4):1559-64 - PubMed
  111. Cell Signal. 2007 Jun;19(6):1221-8 - PubMed
  112. Am J Physiol Endocrinol Metab. 2013 Dec;305(12):E1436-43 - PubMed
  113. Curr Top Med Chem. 2011;11(11):1393-405 - PubMed

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