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Yoon HA, Bartash R, Gendlina I, et al. Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC. medRxiv. 2020;doi: 10.1101/2020.12.02.20242909.
Yoon, H. A., Bartash, R., Gendlina, I., Rivera, J., Nakouzi, A., Bortz, R. H., Wirchnianski, A. S., Paroder, M., Fehn, K., Serrano-Rahman, L., Babb, R., Sarwar, U. N., Haslwanter, D., Laudermilch, E., Florez, C., Dieterle, M. E., Jangra, R. K., Fels, J. M., Tong, K., Mariano, M. C., Vergnolle, O., Georgiev, G. I., Herrera, N. G., Malonis, R. J., Quiroz, J. A., Morano, N. C., Krause, G. J., Sweeney, J. M., Cowman, K., Allen, S., Annam, J., Applebaum, A., Barboto, D., Khokhar, A., Lally, B. J., Lee, A., Lee, M., Malaviya, A., Sample, R., Yang, X. A., Li, Y., Ruiz, R., Thota, R., Barnhill, J., Goldstein, D. Y., Uehlinger, J., Garforth, S. J., Almo, S. C., Lai, J. R., Gil, M. R., Fox, A. S., Chandran, K., Wang, T., Daily, J. P., & Pirofski, L. A. (2020). Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC. medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2020.12.02.20242909
Yoon, Hyun Ah, et al. "Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC." medRxiv : the preprint server for health sciences vol. (2020). doi: https://doi.org/10.1101/2020.12.02.20242909
Yoon HA, Bartash R, Gendlina I, Rivera J, Nakouzi A, Bortz RH, Wirchnianski AS, Paroder M, Fehn K, Serrano-Rahman L, Babb R, Sarwar UN, Haslwanter D, Laudermilch E, Florez C, Dieterle ME, Jangra RK, Fels JM, Tong K, Mariano MC, Vergnolle O, Georgiev GI, Herrera NG, Malonis RJ, Quiroz JA, Morano NC, Krause GJ, Sweeney JM, Cowman K, Allen S, Annam J, Applebaum A, Barboto D, Khokhar A, Lally BJ, Lee A, Lee M, Malaviya A, Sample R, Yang XA, Li Y, Ruiz R, Thota R, Barnhill J, Goldstein DY, Uehlinger J, Garforth SJ, Almo SC, Lai JR, Gil MR, Fox AS, Chandran K, Wang T, Daily JP, Pirofski LA. Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC. medRxiv. 2020 Dec 04; doi: 10.1101/2020.12.02.20242909. PMID: 33300012; PMCID: PMC7724683.
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medRxiv. 2020 Dec 04; doi: 10.1101/2020.12.02.20242909.

Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC.

medRxiv : the preprint server for health sciences

Hyun Ah Yoon, Rachel Bartash, Inessa Gendlina, Johanna Rivera, Antonio Nakouzi, Robert H Bortz, Ariel S Wirchnianski, Monika Paroder, Karen Fehn, Leana Serrano-Rahman, Rachelle Babb, Uzma N Sarwar, Denise Haslwanter, Ethan Laudermilch, Catalina Florez, M Eugenia Dieterle, Rohit K Jangra, J Maximilian Fels, Karen Tong, Margarette C Mariano, Olivia Vergnolle, George I Georgiev, Natalia G Herrera, Ryan J Malonis, Jose A Quiroz, Nicholas C Morano, Gregory J Krause, Joseph M Sweeney, Kelsie Cowman, Stephanie Allen, Jayabhargav Annam, Ariella Applebaum, Daniel Barboto, Ahmed Khokhar, Brianna J Lally, Audrey Lee, Max Lee, Avinash Malaviya, Reise Sample, Xiuyi A Yang, Yang Li, Rafael Ruiz, Raja Thota, Jason Barnhill, Doctor Y Goldstein, Joan Uehlinger, Scott J Garforth, Steven C Almo, Jonathan R Lai, Morayma Reyes Gil, Amy S Fox, Kartik Chandran, Tao Wang, Johanna P Daily, Liise-Anne Pirofski

Affiliations

  1. Division of Infectious Diseases, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY.
  2. Department of Microbiology and Immunology. Albert Einstein College of Medicine, Bronx, NY.
  3. Department of Biochemistry. Albert Einstein College of Medicine, Bronx, NY.
  4. Department of Pathology. Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY.
  5. Department of Oncology. Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY.
  6. Department of Chemistry and Life Science, United States Military Academy at West Point, NY.
  7. Department of Developmental and Molecular Biology. Albert Einstein College of Medicine, Bronx, NY.
  8. Institute of Aging Studies. Albert Einstein College of Medicine, Bronx, NY.
  9. Department Physiology and Biophysics. Albert Einstein College of Medicine, Bronx, NY.
  10. Albert Einstein College of Medicine, Bronx, NY.
  11. Department of Epidemiology and Population Health. Albert Einstein College of Medicine, Bronx, NY.
  12. Network Performance Group. Montefiore Medical Center, Bronx, NY.
  13. Division of Hospital Medicine, Department of Medicine. Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY.

PMID: 33300012 PMCID: PMC7724683 DOI: 10.1101/2020.12.02.20242909

Abstract

Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as treatment for Coronavirus Disease 2019 (COVID-19). We compared the mortality and clinical outcome of patients with COVID-19 who received 200mL of CCP with a Spike protein IgG titer ≥1:2,430 (median 1:47,385) within 72 hours of admission to propensity score-matched controls cared for at a medical center in the Bronx, between April 13 to May 4, 2020. Matching criteria for controls were age, sex, body mass index, race, ethnicity, comorbidities, week of admission, oxygen requirement, D-dimer, lymphocyte counts, corticosteroids, and anticoagulation use. There was no difference in mortality or oxygenation between CCP recipients and controls at day 28. When stratified by age, compared to matched controls, CCP recipients <65 years had 4-fold lower mortality and 4-fold lower deterioration in oxygenation or mortality at day 28. For CCP recipients, pre-transfusion Spike protein IgG, IgM and IgA titers were associated with mortality at day 28 in univariate analyses. No adverse effects of CCP were observed. Our results suggest CCP may be beneficial for hospitalized patients <65 years, but data from controlled trials is needed to validate this finding and establish the effect of ageing on CCP efficacy.

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