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Servaas NH, Zaaraoui-Boutahar F, Wichers CGK, et al. Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4. J Autoimmun. 2020;117:102574doi: 10.1016/j.jaut.2020.102574.
Servaas, N. H., Zaaraoui-Boutahar, F., Wichers, C. G. K., Ottria, A., Chouri, E., Affandi, A. J., Silva-Cardoso, S., van der Kroef, M., Carvalheiro, T., van Wijk, F., Radstake, T. R. D. J., Andeweg, A. C., & Pandit, A. (2021). Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4. Journal of autoimmunity, 117102574. https://doi.org/10.1016/j.jaut.2020.102574
Servaas, N H, et al. "Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4." Journal of autoimmunity vol. 117 (2021): 102574. doi: https://doi.org/10.1016/j.jaut.2020.102574
Servaas NH, Zaaraoui-Boutahar F, Wichers CGK, Ottria A, Chouri E, Affandi AJ, Silva-Cardoso S, van der Kroef M, Carvalheiro T, van Wijk F, Radstake TRDJ, Andeweg AC, Pandit A. Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4. J Autoimmun. 2021 Feb;117:102574. doi: 10.1016/j.jaut.2020.102574. Epub 2020 Dec 08. PMID: 33307312.
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J Autoimmun. 2021 Feb;117:102574. doi: 10.1016/j.jaut.2020.102574. Epub 2020 Dec 08.

Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4.

Journal of autoimmunity

N H Servaas, F Zaaraoui-Boutahar, C G K Wichers, A Ottria, E Chouri, A J Affandi, S Silva-Cardoso, M van der Kroef, T Carvalheiro, F van Wijk, T R D J Radstake, A C Andeweg, A Pandit

Affiliations

  1. Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  2. Department of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
  3. Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  4. Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: [email protected].

PMID: 33307312 DOI: 10.1016/j.jaut.2020.102574

Abstract

The T-cell receptor (TCR) is a highly polymorphic surface receptor that allows T-cells to recognize antigenic peptides presented on the major histocompatibility complex (MHC). Changes in the TCR repertoire have been observed in several autoimmune conditions, and these changes are suggested to predispose autoimmunity. Multiple lines of evidence have implied an important role for T-cells in the pathogenesis of Systemic Sclerosis (SSc), a complex autoimmune disease. One of the major questions regarding the roles of T-cells is whether expansion and activation of T-cells observed in the diseases pathogenesis is antigen driven. To investigate the temporal TCR repertoire dynamics in SSc, we performed high-throughput sequencing of CD4

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Keywords: Autoimmunity; Longitudinal immunosequencing; Repertoire sequencing; Systemic sclerosis; T-cell receptor

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