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Quantification of Double Stranded DNA Breaks and Telomere Length as Proxies for Corneal Damage and Replicative Stress in Human Keratoconus Corneas.

Translational vision science & technology

Wisse RPL, Kuiper JJW, Radstake TRD, Broen JCA.
PMID: 31372311
Transl Vis Sci Technol. 2019 Jul 26;8(4):10. doi: 10.1167/tvst.8.4.10. eCollection 2019 Jul.

PURPOSE: The pathogenesis of keratoconus (KC) is multifactorial, and associated with oxidative stress and subsequent DNA damage. We investigate differences in DNA damage and replicative stress in patients with KC, and in healthy and diseased controls.METHODS: We obtained 64...

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Wisse RPL, Kuiper JJW, Radstake TRD, et al. Quantification of Double Stranded DNA Breaks and Telomere Length as Proxies for Corneal Damage and Replicative Stress in Human Keratoconus Corneas. Transl Vis Sci Technol. 2019;8(4):10doi: 10.1167/tvst.8.4.10.
Wisse, R. P. L., Kuiper, J. J. W., Radstake, T. R. D., & Broen, J. C. A. (2019). Quantification of Double Stranded DNA Breaks and Telomere Length as Proxies for Corneal Damage and Replicative Stress in Human Keratoconus Corneas. Translational vision science & technology, 8(4), 10. https://doi.org/10.1167/tvst.8.4.10
Wisse, Robert P L, et al. "Quantification of Double Stranded DNA Breaks and Telomere Length as Proxies for Corneal Damage and Replicative Stress in Human Keratoconus Corneas." Translational vision science & technology vol. 8,4 (2019): 10. doi: https://doi.org/10.1167/tvst.8.4.10
Wisse RPL, Kuiper JJW, Radstake TRD, Broen JCA. Quantification of Double Stranded DNA Breaks and Telomere Length as Proxies for Corneal Damage and Replicative Stress in Human Keratoconus Corneas. Transl Vis Sci Technol. 2019 Jul 26;8(4):10. doi: 10.1167/tvst.8.4.10. eCollection 2019 Jul. PMID: 31372311; PMCID: PMC6660185.
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Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α.

Rheumatology (Oxford, England)

Ottria A, Zimmermann M, Paardekooper LM, Carvalheiro T, Vazirpanah N, Silva-Cardoso S, Affandi AJ, Chouri E, V D Kroef M, Tieland RG, Bekker CPJ, Wichers CGK, Rossato M, Mocholi-Gimeno E, Tekstra J, Ton E, van Laar JM, Cossu M, Beretta L, Garcia Perez S, Pandit A, Bonte-Mineur F, Reedquist KA, van den Bogaart G, Radstake TRDJ, Marut W.
PMID: 34559222
Rheumatology (Oxford). 2021 Sep 24; doi: 10.1093/rheumatology/keab532. Epub 2021 Sep 24.

OBJECTIVE: Systemic sclerosis (SSc) is a complex disease characterized by vascular abnormalities and inflammation culminating in hypoxia and excessive fibrosis. Previously, we identified CXCL4 as a novel predictive biomarker in SSc. Although CXCL4 is well-studied, the mechanisms driving its...

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Ottria A, Zimmermann M, Paardekooper LM, et al. Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α. Rheumatology (Oxford). 2021;doi: 10.1093/rheumatology/keab532.
Ottria, A., Zimmermann, M., Paardekooper, L. M., Carvalheiro, T., Vazirpanah, N., Silva-Cardoso, S., Affandi, A. J., Chouri, E., V D Kroef, M., Tieland, R. G., Bekker, C. P. J., Wichers, C. G. K., Rossato, M., Mocholi-Gimeno, E., Tekstra, J., Ton, E., van Laar, J. M., Cossu, M., Beretta, L., Garcia Perez, S., Pandit, A., Bonte-Mineur, F., Reedquist, K. A., van den Bogaart, G., Radstake, T. R. D. J., & Marut, W. (2021). Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α. Rheumatology (Oxford, England), . https://doi.org/10.1093/rheumatology/keab532
Ottria, Andrea, et al. "Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α." Rheumatology (Oxford, England) vol. (2021). doi: https://doi.org/10.1093/rheumatology/keab532
Ottria A, Zimmermann M, Paardekooper LM, Carvalheiro T, Vazirpanah N, Silva-Cardoso S, Affandi AJ, Chouri E, V D Kroef M, Tieland RG, Bekker CPJ, Wichers CGK, Rossato M, Mocholi-Gimeno E, Tekstra J, Ton E, van Laar JM, Cossu M, Beretta L, Garcia Perez S, Pandit A, Bonte-Mineur F, Reedquist KA, van den Bogaart G, Radstake TRDJ, Marut W. Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α. Rheumatology (Oxford). 2021 Sep 24; doi: 10.1093/rheumatology/keab532. Epub 2021 Sep 24. PMID: 34559222.
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ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.

The Journal of investigative dermatology

Angiolilli C, Leijten EFA, Bekker CPJ, Eeftink E, Giovannone B, Nordkamp MO, van der Wal M, Thijs JL, Vastert SJ, van Wijk F, Radstake TRDJ, van Loosdregt J.
PMID: 34333017
J Invest Dermatol. 2021 Jul 30; doi: 10.1016/j.jid.2021.06.030. Epub 2021 Jul 30.

Dermal fibroblasts are strategically positioned underneath the basal epidermis layer to support keratinocyte proliferation and extracellular matrix production. In inflammatory conditions, these fibroblasts produce cytokines and chemokines that promote the chemoattraction of immune cells into the dermis and the...

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Angiolilli C, Leijten EFA, Bekker CPJ, et al. ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts. J Invest Dermatol. 2021;doi: 10.1016/j.jid.2021.06.030.
Angiolilli, C., Leijten, E. F. A., Bekker, C. P. J., Eeftink, E., Giovannone, B., Nordkamp, M. O., van der Wal, M., Thijs, J. L., Vastert, S. J., van Wijk, F., Radstake, T. R. D. J., & van Loosdregt, J. (2021). ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts. The Journal of investigative dermatology, . https://doi.org/10.1016/j.jid.2021.06.030
Angiolilli, Chiara, et al. "ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts." The Journal of investigative dermatology vol. (2021). doi: https://doi.org/10.1016/j.jid.2021.06.030
Angiolilli C, Leijten EFA, Bekker CPJ, Eeftink E, Giovannone B, Nordkamp MO, van der Wal M, Thijs JL, Vastert SJ, van Wijk F, Radstake TRDJ, van Loosdregt J. ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts. J Invest Dermatol. 2021 Jul 30; doi: 10.1016/j.jid.2021.06.030. Epub 2021 Jul 30. PMID: 34333017.
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Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4.

Journal of autoimmunity

Servaas NH, Zaaraoui-Boutahar F, Wichers CGK, Ottria A, Chouri E, Affandi AJ, Silva-Cardoso S, van der Kroef M, Carvalheiro T, van Wijk F, Radstake TRDJ, Andeweg AC, Pandit A.
PMID: 33307312
J Autoimmun. 2021 Feb;117:102574. doi: 10.1016/j.jaut.2020.102574. Epub 2020 Dec 08.

The T-cell receptor (TCR) is a highly polymorphic surface receptor that allows T-cells to recognize antigenic peptides presented on the major histocompatibility complex (MHC). Changes in the TCR repertoire have been observed in several autoimmune conditions, and these changes...

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Servaas NH, Zaaraoui-Boutahar F, Wichers CGK, et al. Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4. J Autoimmun. 2020;117:102574doi: 10.1016/j.jaut.2020.102574.
Servaas, N. H., Zaaraoui-Boutahar, F., Wichers, C. G. K., Ottria, A., Chouri, E., Affandi, A. J., Silva-Cardoso, S., van der Kroef, M., Carvalheiro, T., van Wijk, F., Radstake, T. R. D. J., Andeweg, A. C., & Pandit, A. (2021). Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4. Journal of autoimmunity, 117102574. https://doi.org/10.1016/j.jaut.2020.102574
Servaas, N H, et al. "Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4." Journal of autoimmunity vol. 117 (2021): 102574. doi: https://doi.org/10.1016/j.jaut.2020.102574
Servaas NH, Zaaraoui-Boutahar F, Wichers CGK, Ottria A, Chouri E, Affandi AJ, Silva-Cardoso S, van der Kroef M, Carvalheiro T, van Wijk F, Radstake TRDJ, Andeweg AC, Pandit A. Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4. J Autoimmun. 2021 Feb;117:102574. doi: 10.1016/j.jaut.2020.102574. Epub 2020 Dec 08. PMID: 33307312.
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Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine.

Systems medicine (New Rochelle, N.Y.)

Kurnat-Thoma E, Baranova A, Baird P, Brodsky E, Butte AJ, Cheema AK, Cheng F, Dutta S, Grant C, Giordano J, Maitland-van der Zee AH, Fridsma DB, Jarrin R, Kann MG, Keeney J, Loscalzo J, Madhavan G, Maron BA, McBride DK, McKean M, Mun SK, Palmer JC, Patel B, Parakh K, Pariser AR, Pristipino C, Radstake TRDJ, Rajasimha HK, Rouse WB, Rozman D, Saleh A, Schmidt HHHW, Schultz N, Sethi T, Silverman EK, Skopac J, Svab I, Trujillo S, Valentine JE, Verma D, West BJ, Vasudevan S.
PMID: 32226924
Syst Med (New Rochelle). 2020 Feb 26;3(1):22-35. doi: 10.1089/sysm.2020.0001. eCollection 2020.

The

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Kurnat-Thoma E, Baranova A, Baird P, et al. Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine. Syst Med (New Rochelle). 2020;3(1):22-35doi: 10.1089/sysm.2020.0001.
Kurnat-Thoma, E., Baranova, A., Baird, P., Brodsky, E., Butte, A. J., Cheema, A. K., Cheng, F., Dutta, S., Grant, C., Giordano, J., Maitland-van der Zee, A. H., Fridsma, D. B., Jarrin, R., Kann, M. G., Keeney, J., Loscalzo, J., Madhavan, G., Maron, B. A., McBride, D. K., McKean, M., Mun, S. K., Palmer, J. C., Patel, B., Parakh, K., Pariser, A. R., Pristipino, C., Radstake, T. R. D. J., Rajasimha, H. K., Rouse, W. B., Rozman, D., Saleh, A., Schmidt, H. H. H. W., Schultz, N., Sethi, T., Silverman, E. K., Skopac, J., Svab, I., Trujillo, S., Valentine, J. E., Verma, D., West, B. J., & Vasudevan, S. (2020). Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine. Systems medicine (New Rochelle, N.Y.), 3(1), 22-35. https://doi.org/10.1089/sysm.2020.0001
Kurnat-Thoma, Emma, et al. "Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine." Systems medicine (New Rochelle, N.Y.) vol. 3,1 (2020): 22-35. doi: https://doi.org/10.1089/sysm.2020.0001
Kurnat-Thoma E, Baranova A, Baird P, Brodsky E, Butte AJ, Cheema AK, Cheng F, Dutta S, Grant C, Giordano J, Maitland-van der Zee AH, Fridsma DB, Jarrin R, Kann MG, Keeney J, Loscalzo J, Madhavan G, Maron BA, McBride DK, McKean M, Mun SK, Palmer JC, Patel B, Parakh K, Pariser AR, Pristipino C, Radstake TRDJ, Rajasimha HK, Rouse WB, Rozman D, Saleh A, Schmidt HHHW, Schultz N, Sethi T, Silverman EK, Skopac J, Svab I, Trujillo S, Valentine JE, Verma D, West BJ, Vasudevan S. Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine. Syst Med (New Rochelle). 2020 Feb 26;3(1):22-35. doi: 10.1089/sysm.2020.0001. eCollection 2020. PMID: 32226924; PMCID: PMC7099876.
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Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis.

Journal of clinical medicine

Chouri E, Wang M, Hillen MR, Angiolilli C, Silva-Cardoso SC, Wichers CGK, van der Kroef M, Bekker CPJ, Cossu M, van Bon L, Affandi AJ, Carvalheiro T, Pandit A, van Roon JAG, Beretta L, Burgering BMT, Radstake TRDJ, Rossato M.
PMID: 33573268
J Clin Med. 2021 Jan 30;10(3). doi: 10.3390/jcm10030491.

Compelling evidence shows the involvement of plasmacytoid dendritic cells (pDCs) in systemic sclerosis (SSc) pathogenesis. This study investigated whether microRNAs (miRNAs) are involved in the dysregulation of pDCs in SSc patients already at early stages. RNA from circulating pDCs...

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Chouri E, Wang M, Hillen MR, et al. Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis. J Clin Med. 2021;10(3)doi: 10.3390/jcm10030491.
Chouri, E., Wang, M., Hillen, M. R., Angiolilli, C., Silva-Cardoso, S. C., Wichers, C. G. K., van der Kroef, M., Bekker, C. P. J., Cossu, M., van Bon, L., Affandi, A. J., Carvalheiro, T., Pandit, A., van Roon, J. A. G., Beretta, L., Burgering, B. M. T., Radstake, T. R. D. J., & Rossato, M. (2021). Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis. Journal of clinical medicine, 10(3), . https://doi.org/10.3390/jcm10030491
Chouri, Eleni, et al. "Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis." Journal of clinical medicine vol. 10,3 (2021). doi: https://doi.org/10.3390/jcm10030491
Chouri E, Wang M, Hillen MR, Angiolilli C, Silva-Cardoso SC, Wichers CGK, van der Kroef M, Bekker CPJ, Cossu M, van Bon L, Affandi AJ, Carvalheiro T, Pandit A, van Roon JAG, Beretta L, Burgering BMT, Radstake TRDJ, Rossato M. Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis. J Clin Med. 2021 Jan 30;10(3). doi: 10.3390/jcm10030491. PMID: 33573268; PMCID: PMC7866506.
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Semaphorin3B plays a central role in serum-induced arthritis model and is reduced in patients with rheumatoid arthritis.

Arthritis & rheumatology (Hoboken, N.J.)

Igea A, Carvalheiro T, Malvar-Fernández B, Martinez-Ramos S, Rafael-Vidal C, Niemantsverdriet E, Varadé J, Fernández-Carrera A, Jimenez N, McGarry T, Rodriguez-Trillo A, Veale D, Fearon U, Conde C, Pego-Reigosa JM, González-Fernández Á, Reedquist KA, Radstake TRDJ, van der Helm-Van Mil AH, García S.
PMID: 35001548
Arthritis Rheumatol. 2022 Jan 09; doi: 10.1002/art.42065. Epub 2022 Jan 09.

OBJECTIVES: Sema(phorin)3B decreases the migrative and invasive capacities of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) and suppress expression of matrix-metalloproteinases (MMPs). Here, we determined the role of Sema3B in an arthritis mouse model and its expression in RA patients.METHODS:...

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Igea A, Carvalheiro T, Malvar-Fernández B, et al. Semaphorin3B plays a central role in serum-induced arthritis model and is reduced in patients with rheumatoid arthritis. Arthritis Rheumatol. 2022;doi: 10.1002/art.42065.
Igea, A., Carvalheiro, T., Malvar-Fernández, B., Martinez-Ramos, S., Rafael-Vidal, C., Niemantsverdriet, E., Varadé, J., Fernández-Carrera, A., Jimenez, N., McGarry, T., Rodriguez-Trillo, A., Veale, D., Fearon, U., Conde, C., Pego-Reigosa, J. M., González-Fernández, �. �., Reedquist, K. A., Radstake, T. R. D. J., van der Helm-Van Mil, A. H., & García, S. (2022). Semaphorin3B plays a central role in serum-induced arthritis model and is reduced in patients with rheumatoid arthritis. Arthritis & rheumatology (Hoboken, N.J.), . https://doi.org/10.1002/art.42065
Igea, Ana, et al. "Semaphorin3B plays a central role in serum-induced arthritis model and is reduced in patients with rheumatoid arthritis." Arthritis & rheumatology (Hoboken, N.J.) vol. (2022). doi: https://doi.org/10.1002/art.42065
Igea A, Carvalheiro T, Malvar-Fernández B, Martinez-Ramos S, Rafael-Vidal C, Niemantsverdriet E, Varadé J, Fernández-Carrera A, Jimenez N, McGarry T, Rodriguez-Trillo A, Veale D, Fearon U, Conde C, Pego-Reigosa JM, González-Fernández Á, Reedquist KA, Radstake TRDJ, van der Helm-Van Mil AH, García S. Semaphorin3B plays a central role in serum-induced arthritis model and is reduced in patients with rheumatoid arthritis. Arthritis Rheumatol. 2022 Jan 09; doi: 10.1002/art.42065. Epub 2022 Jan 09. PMID: 35001548.
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Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren's Syndrome Patients Identifies CCL5 as a Novel Effector Molecule.

Frontiers in immunology

Hinrichs AC, Blokland SLM, Lopes AP, Wichers CGK, Kruize AA, Pandit A, Radstake TRDJ, van Roon JAG.
PMID: 34386009
Front Immunol. 2021 Jul 27;12:702733. doi: 10.3389/fimmu.2021.702733. eCollection 2021.

INTRODUCTION: CCR9+ Tfh-like pathogenic T helper (Th) cells are elevated in patients with primary Sjögren's syndrome (pSS) and indicated to play a role in pSS immunopathology. Here we delineate the CCR9+ Th cell-specific transcriptome to study the molecular dysregulation...

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Hinrichs AC, Blokland SLM, Lopes AP, et al. Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren's Syndrome Patients Identifies CCL5 as a Novel Effector Molecule. Front Immunol. 2021;12:702733doi: 10.3389/fimmu.2021.702733.
Hinrichs, A. C., Blokland, S. L. M., Lopes, A. P., Wichers, C. G. K., Kruize, A. A., Pandit, A., Radstake, T. R. D. J., & van Roon, J. A. G. (2021). Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren's Syndrome Patients Identifies CCL5 as a Novel Effector Molecule. Frontiers in immunology, 12702733. https://doi.org/10.3389/fimmu.2021.702733
Hinrichs, Anneline C, et al. "Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren's Syndrome Patients Identifies CCL5 as a Novel Effector Molecule." Frontiers in immunology vol. 12 (2021): 702733. doi: https://doi.org/10.3389/fimmu.2021.702733
Hinrichs AC, Blokland SLM, Lopes AP, Wichers CGK, Kruize AA, Pandit A, Radstake TRDJ, van Roon JAG. Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren's Syndrome Patients Identifies CCL5 as a Novel Effector Molecule. Front Immunol. 2021 Jul 27;12:702733. doi: 10.3389/fimmu.2021.702733. eCollection 2021. PMID: 34386009; PMCID: PMC8354142.
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Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes.

Annals of the rheumatic diseases

Acosta-Herrera M, Kerick M, Lopéz-Isac E, Assassi S, Beretta L, Simeón-Aznar CP, Ortego-Centeno N, Proudman SM, Hunzelmann N, Moroncini G, de Vries-Bouwstra JK, Orozco G, Barton A, Herrick AL, Terao C, Allanore Y, Brown MA, Radstake TR, Fonseca C, Denton CP, Mayes MD, Martin J.
PMID: 34096881
Ann Rheum Dis. 2021 Apr 01; doi: 10.1136/annrheumdis-2021-219884. Epub 2021 Apr 01.

OBJECTIVE: The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging the largest SSc genome-wide association study, we aimed to fine-map this region to identify novel human leucocyte antigen (HLA) genetic...

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Acosta-Herrera M, Kerick M, Lopéz-Isac E, et al. Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes. Ann Rheum Dis. 2021;doi: 10.1136/annrheumdis-2021-219884.
Acosta-Herrera, M., Kerick, M., Lopéz-Isac, E., Assassi, S., Beretta, L., Simeón-Aznar, C. P., Ortego-Centeno, N., Proudman, S. M., Hunzelmann, N., Moroncini, G., de Vries-Bouwstra, J. K., Orozco, G., Barton, A., Herrick, A. L., Terao, C., Allanore, Y., Brown, M. A., Radstake, T. R., Fonseca, C., Denton, C. P., Mayes, M. D., & Martin, J. (2021). Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes. Annals of the rheumatic diseases, . https://doi.org/10.1136/annrheumdis-2021-219884
Acosta-Herrera, Marialbert, et al. "Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes." Annals of the rheumatic diseases vol. (2021). doi: https://doi.org/10.1136/annrheumdis-2021-219884
Acosta-Herrera M, Kerick M, Lopéz-Isac E, Assassi S, Beretta L, Simeón-Aznar CP, Ortego-Centeno N, Proudman SM, Hunzelmann N, Moroncini G, de Vries-Bouwstra JK, Orozco G, Barton A, Herrick AL, Terao C, Allanore Y, Brown MA, Radstake TR, Fonseca C, Denton CP, Mayes MD, Martin J. Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes. Ann Rheum Dis. 2021 Apr 01; doi: 10.1136/annrheumdis-2021-219884. Epub 2021 Apr 01. PMID: 34096881; PMCID: PMC8292594.
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RegEnrich gene regulator enrichment analysis reveals a key role of the ETS transcription factor family in interferon signaling.

Communications biology

Tao W, Radstake TRDJ, Pandit A.
PMID: 35017649
Commun Biol. 2022 Jan 11;5(1):31. doi: 10.1038/s42003-021-02991-5.

Changes in a few key transcriptional regulators can lead to different biological states. Extracting the key gene regulators governing a biological state allows us to gain mechanistic insights. Most current tools perform pathway/GO enrichment analysis to identify key genes...

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Tao W, Radstake TRDJ, Pandit A. RegEnrich gene regulator enrichment analysis reveals a key role of the ETS transcription factor family in interferon signaling. Commun Biol. 2022;5(1):31doi: 10.1038/s42003-021-02991-5.
Tao, W., Radstake, T. R. D. J., & Pandit, A. (2022). RegEnrich gene regulator enrichment analysis reveals a key role of the ETS transcription factor family in interferon signaling. Communications biology, 5(1), 31. https://doi.org/10.1038/s42003-021-02991-5
Tao, Weiyang, et al. "RegEnrich gene regulator enrichment analysis reveals a key role of the ETS transcription factor family in interferon signaling." Communications biology vol. 5,1 (2022): 31. doi: https://doi.org/10.1038/s42003-021-02991-5
Tao W, Radstake TRDJ, Pandit A. RegEnrich gene regulator enrichment analysis reveals a key role of the ETS transcription factor family in interferon signaling. Commun Biol. 2022 Jan 11;5(1):31. doi: 10.1038/s42003-021-02991-5. PMID: 35017649.
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Signaling by the inhibitory receptor CD200R is rewired by type I interferon.

Science signaling

van der Vlist M, Ramos MIP, van den Hoogen LL, Hiddingh S, Timmerman LM, de Hond TAP, Kaan ED, van der Kroef M, Lebbink RJ, Peters FMA, Khoury-Hanold W, Fritsch-Stork R, Radstake TRDJ, Meyaard L.
PMID: 34637328
Sci Signal. 2021 Oct 12;14(704):eabb4324. doi: 10.1126/scisignal.abb4324. Epub 2021 Oct 12.

CD200 receptor 1 (CD200R) is an inhibitory immunoreceptor that suppresses Toll-like receptor (TLR)–induced cytokine production through the adaptor protein Dok2 and the GTPase activating protein (GAP) p120-RasGAP, which can be cleaved during mild cellular stress. We found that in...

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van der Vlist M, Ramos MIP, van den Hoogen LL, et al. Signaling by the inhibitory receptor CD200R is rewired by type I interferon. Sci Signal. 2021;14(704):eabb4324doi: 10.1126/scisignal.abb4324.
van der Vlist, M., Ramos, M. I. P., van den Hoogen, L. L., Hiddingh, S., Timmerman, L. M., de Hond, T. A. P., Kaan, E. D., van der Kroef, M., Lebbink, R. J., Peters, F. M. A., Khoury-Hanold, W., Fritsch-Stork, R., Radstake, T. R. D. J., & Meyaard, L. (2021). Signaling by the inhibitory receptor CD200R is rewired by type I interferon. Science signaling, 14(704), eabb4324. https://doi.org/10.1126/scisignal.abb4324
van der Vlist, Michiel, et al. "Signaling by the inhibitory receptor CD200R is rewired by type I interferon." Science signaling vol. 14,704 (2021): eabb4324. doi: https://doi.org/10.1126/scisignal.abb4324
van der Vlist M, Ramos MIP, van den Hoogen LL, Hiddingh S, Timmerman LM, de Hond TAP, Kaan ED, van der Kroef M, Lebbink RJ, Peters FMA, Khoury-Hanold W, Fritsch-Stork R, Radstake TRDJ, Meyaard L. Signaling by the inhibitory receptor CD200R is rewired by type I interferon. Sci Signal. 2021 Oct 12;14(704):eabb4324. doi: 10.1126/scisignal.abb4324. Epub 2021 Oct 12. PMID: 34637328.
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Immune checkpoint inhibitor-associated sarcoidosis: A usually benign disease that does not require immunotherapy discontinuation.

European journal of cancer (Oxford, England : 1990)

Chanson N, Ramos-Casals M, Pundole X, Suijkerbuijk K, José de Barros E Silva M, Lidar M, Benesova K, Leipe J, Acar-Denizli N, Pradère P, Michot JM, Voisin AL, Suárez-Almazor ME, Radstake TRD, Fernandes Moça Trevisani V, Schulze-Koops H, Melin A, Robert C, Mariette X, Baughman RP, Lambotte O.
PMID: 34452793
Eur J Cancer. 2021 Nov;158:208-216. doi: 10.1016/j.ejca.2021.05.041. Epub 2021 Aug 25.

OBJECTIVE: To analyse the clinical patterns of sarcoidosis triggered by immune checkpoint inhibitors (ICIs) in patients with cancer.PATIENTS AND METHODS: The ImmunoCancer International Registry is a big data-sharing multidisciplinary network from 18 countries dedicated to evaluating the clinical research...

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Chanson N, Ramos-Casals M, Pundole X, et al. Immune checkpoint inhibitor-associated sarcoidosis: A usually benign disease that does not require immunotherapy discontinuation. Eur J Cancer. 2021;158:208-216doi: 10.1016/j.ejca.2021.05.041.
Chanson, N., Ramos-Casals, M., Pundole, X., Suijkerbuijk, K., José de Barros E Silva, M., Lidar, M., Benesova, K., Leipe, J., Acar-Denizli, N., Pradère, P., Michot, J. M., Voisin, A. L., Suárez-Almazor, M. E., Radstake, T. R. D., Fernandes Moça Trevisani, V., Schulze-Koops, H., Melin, A., Robert, C., Mariette, X., Baughman, R. P., Lambotte, O. (2021). Immune checkpoint inhibitor-associated sarcoidosis: A usually benign disease that does not require immunotherapy discontinuation. European journal of cancer (Oxford, England : 1990), 158208-216. https://doi.org/10.1016/j.ejca.2021.05.041
Chanson, Noémie, et al. "Immune checkpoint inhibitor-associated sarcoidosis: A usually benign disease that does not require immunotherapy discontinuation." European journal of cancer (Oxford, England : 1990) vol. 158 (2021): 208-216. doi: https://doi.org/10.1016/j.ejca.2021.05.041
Chanson N, Ramos-Casals M, Pundole X, Suijkerbuijk K, José de Barros E Silva M, Lidar M, Benesova K, Leipe J, Acar-Denizli N, Pradère P, Michot JM, Voisin AL, Suárez-Almazor ME, Radstake TRD, Fernandes Moça Trevisani V, Schulze-Koops H, Melin A, Robert C, Mariette X, Baughman RP, Lambotte O. Immune checkpoint inhibitor-associated sarcoidosis: A usually benign disease that does not require immunotherapy discontinuation. Eur J Cancer. 2021 Nov;158:208-216. doi: 10.1016/j.ejca.2021.05.041. Epub 2021 Aug 25. PMID: 34452793.
Copy Download .nbib Format: NLM
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