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Qiao Y, Wang XM, Mannan R, et al. Targeting transcriptional regulation of SARS-CoV-2 entry factors . Proc Natl Acad Sci U S A. 2020;doi: 10.1073/pnas.2021450118.
Qiao, Y., Wang, X. M., Mannan, R., Pitchiaya, S., Zhang, Y., Wotring, J. W., Xiao, L., Robinson, D. R., Wu, Y. M., Tien, J. C., Cao, X., Simko, S. A., Apel, I. J., Bawa, P., Kregel, S., Narayanan, S. P., Raskind, G., Ellison, S. J., Parolia, A., Zelenka-Wang, S., McMurry, L., Su, F., Wang, R., Cheng, Y., Delekta, A. D., Mei, Z., Pretto, C. D., Wang, S., Mehra, R., Sexton, J. Z., & Chinnaiyan, A. M. (2020). Targeting transcriptional regulation of SARS-CoV-2 entry factors . Proceedings of the National Academy of Sciences of the United States of America, . https://doi.org/10.1073/pnas.2021450118
Qiao, Yuanyuan, et al. "Targeting transcriptional regulation of SARS-CoV-2 entry factors ." Proceedings of the National Academy of Sciences of the United States of America vol. (2020). doi: https://doi.org/10.1073/pnas.2021450118
Qiao Y, Wang XM, Mannan R, Pitchiaya S, Zhang Y, Wotring JW, Xiao L, Robinson DR, Wu YM, Tien JC, Cao X, Simko SA, Apel IJ, Bawa P, Kregel S, Narayanan SP, Raskind G, Ellison SJ, Parolia A, Zelenka-Wang S, McMurry L, Su F, Wang R, Cheng Y, Delekta AD, Mei Z, Pretto CD, Wang S, Mehra R, Sexton JZ, Chinnaiyan AM. Targeting transcriptional regulation of SARS-CoV-2 entry factors . Proc Natl Acad Sci U S A. 2020 Dec 11; doi: 10.1073/pnas.2021450118. Epub 2020 Dec 11. PMID: 33310900; PMCID: PMC7817128.
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Proc Natl Acad Sci U S A. 2020 Dec 11; doi: 10.1073/pnas.2021450118. Epub 2020 Dec 11.

Targeting transcriptional regulation of SARS-CoV-2 entry factors .

Proceedings of the National Academy of Sciences of the United States of America

Yuanyuan Qiao, Xiao-Ming Wang, Rahul Mannan, Sethuramasundaram Pitchiaya, Yuping Zhang, Jesse W Wotring, Lanbo Xiao, Dan R Robinson, Yi-Mi Wu, Jean Ching-Yi Tien, Xuhong Cao, Stephanie A Simko, Ingrid J Apel, Pushpinder Bawa, Steven Kregel, Sathiya P Narayanan, Gregory Raskind, Stephanie J Ellison, Abhijit Parolia, Sylvia Zelenka-Wang, Lisa McMurry, Fengyun Su, Rui Wang, Yunhui Cheng, Andrew D Delekta, Zejie Mei, Carla D Pretto, Shaomeng Wang, Rohit Mehra, Jonathan Z Sexton, Arul M Chinnaiyan

Affiliations

  1. Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
  2. Department of Pathology, University of Michigan, Ann Arbor, MI 48109.
  3. Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109.
  4. Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109.
  5. Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109.
  6. State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Shanghai 200031, China.
  7. Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
  8. Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109.
  9. Center for Drug Repurposing, University of Michigan, Ann Arbor, MI 48109.
  10. Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI 48109.
  11. Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109; [email protected].
  12. Department of Urology, University of Michigan, Ann Arbor, MI 48109.

PMID: 33310900 PMCID: PMC7817128 DOI: 10.1073/pnas.2021450118

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, employs two key host proteins to gain entry and replicate within cells, angiotensin-converting enzyme 2 (ACE2) and the cell surface transmembrane protease serine 2 (TMPRSS2).

Copyright © 2020 the Author(s). Published by PNAS.

Keywords: ACE2; BET inhibitors; SARS-CoV-2; TMPRSS2; androgen receptor

Conflict of interest statement

The authors declare no competing interest.

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