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Bohlok A, Vermeulen P, Leduc S, et al. Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients. NPJ Breast Cancer. 2020;6(1):64doi: 10.1038/s41523-020-00209-1.
Bohlok, A., Vermeulen, P., Leduc, S., Latacz, E., Botzenhart, L., Richard, F., De Schepper, M., Geukens, T., Lucidi, V., Ignatiadis, M., Aftimos, P., Sotiriou, C., Piccart, M., Hendlisz, A., Van Laere, S., Dirix, L., Noël, J. C., Biganzoli, E., Larsimont, D., Desmedt, C., & Donckier, V. (2020). Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients. NPJ breast cancer, 6(1), 64. https://doi.org/10.1038/s41523-020-00209-1
Bohlok, Ali, et al. "Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients." NPJ breast cancer vol. 6,1 (2020): 64. doi: https://doi.org/10.1038/s41523-020-00209-1
Bohlok A, Vermeulen P, Leduc S, Latacz E, Botzenhart L, Richard F, De Schepper M, Geukens T, Lucidi V, Ignatiadis M, Aftimos P, Sotiriou C, Piccart M, Hendlisz A, Van Laere S, Dirix L, Noël JC, Biganzoli E, Larsimont D, Desmedt C, Donckier V. Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients. NPJ Breast Cancer. 2020 Dec 18;6(1):64. doi: 10.1038/s41523-020-00209-1. PMID: 33339824; PMCID: PMC7749172.
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NPJ Breast Cancer. 2020 Dec 18;6(1):64. doi: 10.1038/s41523-020-00209-1.

Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients.

NPJ breast cancer

Ali Bohlok, Peter Vermeulen, Sophia Leduc, Emily Latacz, Lara Botzenhart, François Richard, Maxim De Schepper, Tatjana Geukens, Valerio Lucidi, Michail Ignatiadis, Philippe Aftimos, Christos Sotiriou, Martine Piccart, Alain Hendlisz, Steven Van Laere, Luc Dirix, Jean-Christophe Noël, Elia Biganzoli, Denis Larsimont, Christine Desmedt, Vincent Donckier

Affiliations

  1. Department of Surgery, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  2. Translational Cancer Research Unit, GZA Hospitals & CORE, MIPRO, University of Antwerp, Antwerp, Belgium.
  3. Department of Oncological Research, Oncology Center, GZA Hospitals Sint-Augustinus, Antwerp, Belgium.
  4. Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
  5. Department of Abdominal Surgery, Hôpital Erasme, Université Libre de Bruxelles, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  6. Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  7. Clinical Trials Conduct Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  8. Breast Cancer Translational Lab, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  9. Medical Oncology Department, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  10. Department of Pathology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
  11. Department of Clinical Sciences and Community Health & DSRC, University of Milan, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
  12. Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  13. Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium. [email protected].
  14. Department of Surgery, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. [email protected].

PMID: 33339824 PMCID: PMC7749172 DOI: 10.1038/s41523-020-00209-1

Abstract

Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery. Survival analyses showed that the presence of a desmoplastic HGP in the liver metastases (a rim of fibrous tissue separating cancer cells from the liver parenchyma, present in 20 (56%) patients) is independently associated with favorable progression-free and overall survival when compared with the replacement HGP (cancer cells growing into the liver parenchyma, present in 16 (44%) patients).

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