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Showing 1 to 12 of 18 entries
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Tumor Banks: A Quality Control Scheme Proposal.

Frontiers in medicine

Craciun L, Spinette SA, Rassy M, Salgado R, de Wind A, Demetter P, Verset L, Gomez-Galdon M, Chintinne M, Sirtaine N, de St Aubain N, Laios I, Roy F, Larsimont D.
PMID: 31681781
Front Med (Lausanne). 2019 Oct 17;6:225. doi: 10.3389/fmed.2019.00225. eCollection 2019.

No abstract available.

Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients.

NPJ breast cancer

Bohlok A, Vermeulen P, Leduc S, Latacz E, Botzenhart L, Richard F, De Schepper M, Geukens T, Lucidi V, Ignatiadis M, Aftimos P, Sotiriou C, Piccart M, Hendlisz A, Van Laere S, Dirix L, Noël JC, Biganzoli E, Larsimont D, Desmedt C, Donckier V.
PMID: 33339824
NPJ Breast Cancer. 2020 Dec 18;6(1):64. doi: 10.1038/s41523-020-00209-1.

Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who...

Immune Checkpoint Molecules on Tumor-Infiltrating Lymphocytes and Their Association with Tertiary Lymphoid Structures in Human Breast Cancer.

Frontiers in immunology

Solinas C, Garaud S, De Silva P, Boisson A, Van den Eynden G, de Wind A, Risso P, Rodrigues Vitória J, Richard F, Migliori E, Noël G, Duvillier H, Craciun L, Veys I, Awada A, Detours V, Larsimont D, Piccart-Gebhart M, Willard-Gallo K.
PMID: 29163490
Front Immunol. 2017 Oct 30;8:1412. doi: 10.3389/fimmu.2017.01412. eCollection 2017.

There is an exponentially growing interest in targeting immune checkpoint molecules in breast cancer (BC), particularly in the triple-negative subtype where unmet treatment needs remain. This study was designed to analyze the expression, localization, and prognostic role of PD-1,...

Genome-wide gene expression profiling to predict resistance to anthracyclines in breast cancer patients.

Genomics data

Haibe-Kains B, Desmedt C, Di Leo A, Azambuja E, Larsimont D, Selleslags J, Delaloge S, Duhem C, Kains JP, Carly B, Maerevoet M, Vindevoghel A, Rouas G, Lallemand F, Durbecq V, Cardoso F, Salgado R, Rovere R, Bontempi G, Michiels S, Buyse M, Nogaret JM, Qi Y, Symmans F, Pusztai L, D'Hondt V, Piccart-Gebhart M, Sotiriou C.
PMID: 26484051
Genom Data. 2013 Oct 01;1:7-10. doi: 10.1016/j.gdata.2013.09.001. eCollection 2013 Dec.

Validated biomarkers predictive of response/resistance to anthracyclines in breast cancer are currently lacking. The neoadjuvant Trial of Principle (TOP) study, in which patients with estrogen receptor (ER)-negative tumors were treated with anthracycline (epirubicin) monotherapy, was specifically designed to evaluate...

Pathology as the cornerstone of human tissue banking: European consensus expert group report.

Biopreservation and biobanking

Hainaut P, Caboux E, Bevilacqua G, Bosman F, Dassesse T, Hoefler H, Janin A, Langer R, Larsimont D, Morente M, Riegman P, Schirmacher P, Stanta G, Zatloukal K.
PMID: 24835883
Biopreserv Biobank. 2009 Sep;7(3):157-60. doi: 10.1089/bio.2010.7303.

Aside from ethical considerations, the primary requirement for usage of human tissues in basic or translational research is the thorough characterization of tissues. The second, but equally essential, requirement is that tissues be collected, processed, annotated, and preserved in...

N-Acetylcysteine breaks resistance to trastuzumab caused by MUC4 overexpression in human HER2 positive BC-bearing nude mice monitored by .

Oncotarget

Wimana Z, Gebhart G, Guiot T, Vanderlinden B, Larsimont D, Doumont G, Van Simaeys G, Goldman S, Flamen P, Ghanem G.
PMID: 28915583
Oncotarget. 2017 Apr 10;8(34):56185-56198. doi: 10.18632/oncotarget.17015. eCollection 2017 Aug 22.

Trastuzumab remains an important drug in the management of human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer (BC). Several studies reported resistance mechanisms to trastuzumab, including impaired HER2-accessibility caused by mucin 4 (MUC4). Previously, we demonstrated an...

Characterization of Stromal Tumor-infiltrating Lymphocytes and Genomic Alterations in Metastatic Lobular Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Richard F, Majjaj S, Venet D, Rothé F, Pingitore J, Boeckx B, Marchio C, Clatot F, Bertucci F, Mariani O, Galant C, Eynden GVD, Salgado R, Biganzoli E, Lambrechts D, Vincent-Salomon A, Pruneri G, Larsimont D, Sotiriou C, Desmedt C.
PMID: 32943456
Clin Cancer Res. 2020 Dec 01;26(23):6254-6265. doi: 10.1158/1078-0432.CCR-20-2268. Epub 2020 Sep 17.

PURPOSE: Invasive lobular carcinoma (ILC) represents the second most common histologic breast cancer subtype after invasive ductal carcinoma (IDC). While primary ILC has been extensively studied, metastatic ILC has been poorly characterized at the genomic and immune level.EXPERIMENTAL DESIGN:...

Fluorescent Multiplex Immunohistochemistry Coupled With Other State-Of-The-Art Techniques to Systematically Characterize the Tumor Immune Microenvironment.

Frontiers in molecular biosciences

Boisson A, Noël G, Saiselet M, Rodrigues-Vitória J, Thomas N, Fontsa ML, Sofronii D, Naveaux C, Duvillier H, Craciun L, Larsimont D, Awada A, Detours V, Willard-Gallo K, Garaud S.
PMID: 34621785
Front Mol Biosci. 2021 Sep 21;8:673042. doi: 10.3389/fmolb.2021.673042. eCollection 2021.

Our expanding knowledge of the interactions between tumor cells and their microenvironment has helped to revolutionize cancer treatments, including the more recent development of immunotherapies. Immune cells are an important component of the tumor microenvironment that influence progression and...

Systemic Sentinel Lymph Node Detection Using Fluorescence Imaging After Indocyanine Green Intravenous Injection in Colorectal Cancer: Protocol for a Feasibility Study.

JMIR research protocols

Liberale G, Vankerckhove S, Bouazza F, Gomez Galdon M, Larsimont D, Moreau M, Bourgeois P, Donckier V.
PMID: 32554370
JMIR Res Protoc. 2020 Aug 14;9(8):e17976. doi: 10.2196/17976.

BACKGROUND: Nodal staging is a major concern in colorectal cancer as it is an important prognostic factor. Several techniques that could potentially improve patient treatment and prognosis have been developed to increase the accuracy of nodal staging. Sentinel lymph...

Comparison of immunohistochemical and biochemical measurement of steroid receptors in breast cancer: are both still necessary?.

Breast (Edinburgh, Scotland)

Gotlieb L, Kaufman L, Leclercq G, Nogaret JM, Buggenhout A, Larsimont D.
PMID: 14965626
Breast. 2001 Dec;10(6):470-5. doi: 10.1054/brst.2000.0283.

In our institute, the oestrogen and progesterone receptors of breast cancer samples are analyzed by biochemistry and immunohistochemistry. The purpose of this study is to evaluate and compare both techniques and establish whether one of them should be used...

Early invasive cancer and partial intraoperative electron radiation therapy of the breast: experience of the jules bordet institute.

International journal of breast cancer

Philippson C, Simon S, Vandekerkhove C, Hertens D, Veys I, Noterman D, De Neubourg F, Larsimont D, Bourgeois P, Van Houtte P, Nogaret JM.
PMID: 25009747
Int J Breast Cancer. 2014;2014:627352. doi: 10.1155/2014/627352. Epub 2014 Jun 09.

Objectives. The aim of this prospective phase II study is to evaluate the treatment of early-stage breast cancer (T1 N0) with intraoperative electron radiation therapy (IOERT) in terms of local control, early complications, and cosmesis. Patients and Methods. From...

Tumor-infiltrating lymphocyte composition, organization and PD-1/ PD-L1 expression are linked in breast cancer.

Oncoimmunology

Buisseret L, Garaud S, de Wind A, Van den Eynden G, Boisson A, Solinas C, Gu-Trantien C, Naveaux C, Lodewyckx JN, Duvillier H, Craciun L, Veys I, Larsimont D, Piccart-Gebhart M, Stagg J, Sotiriou C, Willard-Gallo K.
PMID: 28197375
Oncoimmunology. 2016 Dec 14;6(1):e1257452. doi: 10.1080/2162402X.2016.1257452. eCollection 2017.

The clinical relevance of tumor-infiltrating lymphocytes (TIL) in breast cancer (BC) has been clearly established by their demonstrated correlation with long-term positive outcomes. Nevertheless, the relationship between protective immunity, observed in some patients, and critical features of the infiltrate...

Showing 1 to 12 of 18 entries