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Mayr L, Guntner AS, Madlener S, et al. Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated . J Pers Med. 2020;10(4)doi: 10.3390/jpm10040290.
Mayr, L., Guntner, A. S., Madlener, S., Schmook, M. T., Peyrl, A., Azizi, A. A., Dieckmann, K., Reisinger, D., Stepien, N. M., Schramm, K., Laemmerer, A., Jones, D. T. W., Ecker, J., Sahm, F., Milde, T., Pajtler, K. W., Blattner-Johnson, M., Strbac, M., Dorfer, C., Czech, T., Kirchhofer, D., Gabler, L., Berger, W., Haberler, C., Müllauer, L., Buchberger, W., Slavc, I., Lötsch-Gojo, D., & Gojo, J. (2020). Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated . Journal of personalized medicine, 10(4), . https://doi.org/10.3390/jpm10040290
Mayr, Lisa, et al. "Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ." Journal of personalized medicine vol. 10,4 (2020). doi: https://doi.org/10.3390/jpm10040290
Mayr L, Guntner AS, Madlener S, Schmook MT, Peyrl A, Azizi AA, Dieckmann K, Reisinger D, Stepien NM, Schramm K, Laemmerer A, Jones DTW, Ecker J, Sahm F, Milde T, Pajtler KW, Blattner-Johnson M, Strbac M, Dorfer C, Czech T, Kirchhofer D, Gabler L, Berger W, Haberler C, Müllauer L, Buchberger W, Slavc I, Lötsch-Gojo D, Gojo J. Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated . J Pers Med. 2020 Dec 18;10(4). doi: 10.3390/jpm10040290. PMID: 33353026; PMCID: PMC7766483.
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J Pers Med. 2020 Dec 18;10(4). doi: 10.3390/jpm10040290.

Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated .

Journal of personalized medicine

Lisa Mayr, Armin S Guntner, Sibylle Madlener, Maria T Schmook, Andreas Peyrl, Amedeo A Azizi, Karin Dieckmann, Dominik Reisinger, Natalia M Stepien, Kathrin Schramm, Anna Laemmerer, David T W Jones, Jonas Ecker, Felix Sahm, Till Milde, Kristian W Pajtler, Mirjam Blattner-Johnson, Miroslav Strbac, Christian Dorfer, Thomas Czech, Dominik Kirchhofer, Lisa Gabler, Walter Berger, Christine Haberler, Leonhard Müllauer, Wolfgang Buchberger, Irene Slavc, Daniela Lötsch-Gojo, Johannes Gojo

Affiliations

  1. Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
  2. Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, 1090 Vienna, Austria.
  3. Comprehensive Cancer Center-Central Nervous System Tumors Unit, Medical University of Vienna, 1090 Vienna, Austria.
  4. Institute of Analytical Chemistry, Johannes Kepler University, 4020 Linz, Austria.
  5. Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
  6. Department of Radiotherapy, Medical University of Vienna, 1090 Vienna, Austria.
  7. Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.
  8. Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  9. Clinical Cooperation Unit Pediatric Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.
  10. Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  11. Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  12. Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  13. Department of Pediatric Oncology, Hematology, and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  14. Department of Laboratory Medicine and Pathology, Tree Top Hospital, Hulhumale 23000, Maldives.
  15. Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria.
  16. Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.
  17. Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria.

PMID: 33353026 PMCID: PMC7766483 DOI: 10.3390/jpm10040290

Abstract

Targeting oncogenic fusion-genes in pediatric high-grade gliomas (pHGG) with entrectinib has emerged as a highly promising therapeutic approach. Despite ongoing clinical studies, to date, no reports on the treatment of cerebrospinal fluid (CSF) disseminated fusion-positive pHGG exist. Moreover, clinically important information of combination with other treatment modalities such as intrathecal therapy, radiotherapy and other targeted agents is missing. We report on our clinical experience of entrectinib therapy in two CSF disseminated

Keywords: CSF penetrance; NTRK fusion; ROS1 fusion; abemaciclib; entrectinib; radiotherapy; targeted therapies; trametinib

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