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González-Casimiro CM, Merino B, Casanueva-Álvarez E, et al. Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme. Biomedicines. 2021;9(1)doi: 10.3390/biomedicines9010086.
González-Casimiro, C. M., Merino, B., Casanueva-Álvarez, E., Postigo-Casado, T., Cámara-Torres, P., Fernández-Díaz, C. M., Leissring, M. A., Cózar-Castellano, I., & Perdomo, G. (2021). Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme. Biomedicines, 9(1), . https://doi.org/10.3390/biomedicines9010086
González-Casimiro, Carlos M, et al. "Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme." Biomedicines vol. 9,1 (2021). doi: https://doi.org/10.3390/biomedicines9010086
González-Casimiro CM, Merino B, Casanueva-Álvarez E, Postigo-Casado T, Cámara-Torres P, Fernández-Díaz CM, Leissring MA, Cózar-Castellano I, Perdomo G. Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme. Biomedicines. 2021 Jan 17;9(1). doi: 10.3390/biomedicines9010086. PMID: 33477364; PMCID: PMC7830943.
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Biomedicines. 2021 Jan 17;9(1). doi: 10.3390/biomedicines9010086.

Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme.

Biomedicines

Carlos M González-Casimiro, Beatriz Merino, Elena Casanueva-Álvarez, Tamara Postigo-Casado, Patricia Cámara-Torres, Cristina M Fernández-Díaz, Malcolm A Leissring, Irene Cózar-Castellano, Germán Perdomo

Affiliations

  1. Instituto de Biología y Genética Molecular, University of Valladolid-CSIC, 47003 Valladolid, Spain.
  2. Molecular Oncology Group, IMDEA Food Institute, CEI UAM + CSIC, 28049 Madrid, Spain.
  3. Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA 92697, USA.
  4. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28029 Madrid, Spain.

PMID: 33477364 PMCID: PMC7830943 DOI: 10.3390/biomedicines9010086

Abstract

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed metalloprotease that degrades insulin and several other intermediate-size peptides. For many decades, IDE had been assumed to be involved primarily in hepatic insulin clearance, a key process that regulates availability of circulating insulin levels for peripheral tissues. Emerging evidence, however, suggests that IDE has several other important physiological functions relevant to glucose and insulin homeostasis, including the regulation of insulin secretion from pancreatic β-cells. Investigation of mice with tissue-specific genetic deletion of

Keywords: glucose transporters; insulin receptor; insulin resistance; insulin-degrading enzyme; liver; pancreas

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