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Eur J Appl Physiol. 2021 Apr;121(4):969-992. doi: 10.1007/s00421-020-04566-4. Epub 2021 Jan 08.

Exercise-induced muscle damage: mechanism, assessment and nutritional factors to accelerate recovery.

European journal of applied physiology

I Markus, K Constantini, J R Hoffman, S Bartolomei, Yftach Gepner

Affiliations

  1. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, and Sylvan Adams Sports Institute, Tel-Aviv University, Tel-Aviv, Israel.
  2. Department of Physical Therapy, Ariel University, Ariel, Israel.
  3. Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  4. Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, and Sylvan Adams Sports Institute, Tel-Aviv University, Tel-Aviv, Israel. [email protected].

PMID: 33420603 DOI: 10.1007/s00421-020-04566-4

Abstract

There have been a multitude of reviews written on exercise-induced muscle damage (EIMD) and recovery. EIMD is a complex area of study as there are a host of factors such as sex, age, nutrition, fitness level, genetics and familiarity with exercise task, which influence the magnitude of performance decrement and the time course of recovery following EIMD. In addition, many reviews on recovery from exercise have ranged from the impact of nutritional strategies and recovery modalities, to complex mechanistic examination of various immune and endocrine signaling molecules. No one review can adequately address this broad array of study. Thus, in this present review, we aim to examine EIMD emanating from both endurance exercise and resistance exercise training in recreational and competitive athletes and shed light on nutritional strategies that can enhance and accelerate recovery following EIMD. In addition, the evaluation of EIMD and recovery from exercise is often complicated and conclusions often depend of the specific mode of assessment. As such, the focus of this review is also directed at the available techniques used to assess EIMD.

Keywords: Endurance; Exercise; Inflammation; Muscle damage; Nutrition; Strength

References

  1. Abbott BC, Bigland B, Ritchie JM (1952) The physiological cost of negative work. J Physiol 117:380–390. https://doi.org/10.1113/jphysiol.1952.sp004755 - PubMed
  2. Aben HGJ, Hills SP, Higgins D et al (2020) The reliability of neuromuscular and perceptual measures used to profile recovery, and the time-course of such responses following academy rugby league match-play. Sports 8:73. https://doi.org/10.3390/sports8050073 - PubMed
  3. Ahtiainen JP, Häkkinen K (2009) Strength athletes are capable to produce greater muscle activation and neural fatigue during high-intensity resistance exercise than nonathletes. J Strength Cond Res 23:1129–1134. https://doi.org/10.1519/JSC.0b013e3181aa1b72 - PubMed
  4. Allen J, Sun Y, Woods JA (2015) Exercise and the regulation of inflammatory responses. Prog Mol Biol Transl Sci 135:337–354. https://doi.org/10.1016/bs.pmbts.2015.07.003 - PubMed
  5. Allen TJ, Jones T, Tsay A et al (2018) Muscle damage produced by isometric contractions in human elbow flexors. J Appl Physiol 124:388–399. https://doi.org/10.1152/japplphysiol.00535.2017 - PubMed
  6. Anderson EJ, Neufer PD (2006) Type II skeletal myofibers possess unique properties that potentiate mitochondrial H - PubMed
  7. Andersson H, Raastad T, Nilsson J et al (2008) Neuromuscular fatigue and recovery in elite female soccer: effects of active recovery. Med Sci Sports Exerc 40:372–380. https://doi.org/10.1249/mss.0b013e31815b8497 - PubMed
  8. Arent SM, Senso M, Golem DL, McKeever KH (2010) The effects of theaflavin-enriched black tea extract on muscle soreness, oxidative stress, inflammation, and endocrine responses to acute anaerobic interval training: a randomized, double-blind, crossover study. J Int Soc Sports Nutr. https://doi.org/10.1186/1550-2783-7-11 - PubMed
  9. Arnhold J, Flemmig J (2010) Human myeloperoxidase in innate and acquired immunity. Arch Biochem Biophys 500:92–106 - PubMed
  10. Arroyo E, Jajtner AR (2019) Vitamins and minerals. In: Dietary supplementation in sport and exercise. Routledge, Milton Park, Abingdon, Oxon; New York, NY : Routledge, 2019. |Includes bibliographical references and index, pp 22–46 - PubMed
  11. Arroyo E, Wells AJ, Gordon JA et al (2017) Tumor necrosis factor-alpha and soluble TNF-alpha receptor responses in young vs. middle-aged males following eccentric exercise. Exp Gerontol 100:28–35. https://doi.org/10.1016/j.exger.2017.10.012 - PubMed
  12. Assumpção C de O, Lima LCR, Oliveira FBD et al (2013) Exercise-induced muscle damage and running economy in humans. Sci World J vol.2013. - PubMed
  13. Baird MF, Graham SM, Baker JS et al (2012) Creatine-kinase-and exercise-related muscle damage implications for muscle performance and recovery. J Nutr Metab 2012:13. https://doi.org/10.1155/2012/960363 - PubMed
  14. Bartolomei S, Sadres E, Church DD et al (2017) Comparison of the recovery response from high-intensity and high-volume resistance exercise in trained men. Eur J Appl Physiol 117:1287–1298. https://doi.org/10.1007/s00421-017-3598-9 - PubMed
  15. Bartolomei S, Totti V, Griggio F et al (2019a) Upper-body resistance exercise reduces time to recover after a high-volume bench press protocol in resistance-trained men. J Strength Cond Res. https://doi.org/10.1519/JSC.0000000000002960 - PubMed
  16. Bartolomei S, Totti V, Nigro F et al (2019b) A comparison between the recovery responses following an eccentrically loaded bench press protocol vs. regular loading in highly trained men. J Hum Kinet 68:59–67. https://doi.org/10.2478/hukin-2019-0056 - PubMed
  17. Baumert P, Lake MJ, Stewart CE et al (2016) Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing. Eur J Appl Physiol 116:1595–1625 - PubMed
  18. Beaven CM, Willis SJ, Cook CJ, Holmberg H-C (2014) Physiological comparison of concentric and eccentric arm cycling in males and females. PLoS One 9:e112079. https://doi.org/10.1371/journal.pone.0112079 - PubMed
  19. Behm DG, Button DC, Barbour G et al (2004) Conflicting effects of fatigue and potentiation on voluntary force. J Strength Cond Res 18:365–372. https://doi.org/10.1519/R-12982.1 - PubMed
  20. Berry DB, You S, Warner J et al (2017) A 3D tissue-printing approach for validation of diffusion tensor imaging in skeletal muscle. Tissue Eng Part A 23:980–988. https://doi.org/10.1089/ten.tea.2016.0438 - PubMed
  21. Bessa AL, Oliveira VN, Agostini G et al (2016) Exercise intensity and recovery. J Strength Cond Res 30:311–319. https://doi.org/10.1519/JSC.0b013e31828f1ee9 - PubMed
  22. Beyer KS, Stout JR, Fukuda DH et al (2017) Impact of polyphenol supplementation on acute and chronic response to resistance training. J Strength Cond Res 31:2945–2954. https://doi.org/10.1519/JSC.0000000000002104 - PubMed
  23. Biglands JD, Grainger AJ, Robinson P et al (2020) MRI in acute muscle tears in athletes: can quantitative T2 and DTI predict return to play better than visual assessment? Eur Radiol. https://doi.org/10.1007/s00330-020-06999-z - PubMed
  24. Black CD, Dobson RM (2013) Prior eccentric exercise augments muscle pain and perception of effort during cycling exercise. Clin J Pain 29:443–449. https://doi.org/10.1097/AJP.0b013e318262ddfe - PubMed
  25. Bloomer RJ, Goldfarb AH, Wideman L et al (2005) Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress. J Strength Cond Res 19:276. https://doi.org/10.1519/14823.1 - PubMed
  26. Bloomer R, Schriefer J, Gunnels T et al (2018) Nutrient intake and physical exercise significantly impact physical performance, body composition, blood lipids, oxidative stress, and inflammation in male rats. Nutrients 10:1109. https://doi.org/10.3390/nu10081109 - PubMed
  27. Boirie Y, Dangin M, Gachon P et al (1997) Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci USA 94:14930–14935. https://doi.org/10.1073/pnas.94.26.14930 - PubMed
  28. Boldyrev A, Bulygina E, Leinsoo T et al (2004) Protection of neuronal cells against reactive oxygen species by carnosine and related compounds. Comp Biochem Physiol B Biochem Mol Biol 137:81–88. https://doi.org/10.1016/j.cbpc.2003.10.008 - PubMed
  29. Boldyrev AA, Stvolinsky SL, Fedorova TN, Suslina ZA (2010) Carnosine as a natural antioxidant and geroprotector: From molecular mechanisms to clinical trials. Rejuvenation Res 13:156–158. https://doi.org/10.1089/rej.2009.0923 - PubMed
  30. Boldyrev AA, Aldini G, Derave W (2013) Physiology and pathophysiology of carnosine. Physiol Rev 93:1803–1845. https://doi.org/10.1152/physrev.00039.2012 - PubMed
  31. Bowtell JL, Sumners DP, Dyer A et al (2011) Montmorency cherry juice reduces muscle damage caused by intensive strength exercise. Med Sci Sports Exerc 43:1544–1551 - PubMed
  32. Boychuk KE, Lanovaz JL, Krentz JR et al (2016) Creatine supplementation does not alter neuromuscular recovery after eccentric exercise. Muscle Nerve 54:487–495. https://doi.org/10.1002/mus.25091 - PubMed
  33. Braun WA, Dutto DJ (2003) The effects of a single bout of downhill running and ensuing delayed onset of muscle soreness on running economy performed 48 h later. Eur J Appl Physiol 90:29–34. https://doi.org/10.1007/s00421-003-0857-8 - PubMed
  34. Burd NA, Yang Y, Moore DR et al (2012) Greater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. micellar casein at rest and after resistance exercise in elderly men. Br J Nutr 108:958–962. https://doi.org/10.1017/S0007114511006271 - PubMed
  35. Burt DG, Twist C (2011) The effects of exercise-induced muscle damage on cycling time-trial performance. J Strength Cond Res 25:2185–2192. https://doi.org/10.1519/JSC.0b013e3181e86148 - PubMed
  36. Byrne C, Eston R (2002) The effect of exercise-induced muscle damage on isometric and dynamic knee extensor strength and vertical jump performance. J Sports Sci 20:417–425. https://doi.org/10.1080/026404102317366672 - PubMed
  37. Byrne C, Eston RG, Edwards RHT (2001) Characteristics of isometric and dynamic strength loss following eccentric exercise-induced muscle damage. Scand J Med Sci Sports 11:134–140. https://doi.org/10.1046/j.1524-4725.2001.110302.x - PubMed
  38. Byrne C, Twist C, Eston R (2004) Neuromuscular function after exercise-induced muscle damage: theoretical and applied implications. Sport Med 34:49–69 - PubMed
  39. Castiglioni A, Corna G, Rigamonti E et al (2015) FOXP3+ T cells recruited to sites of sterile skeletal muscle injury regulate the fate of satellite cells and guide effective tissue regeneration. PLoS One. https://doi.org/10.1371/journal.pone.0128094 - PubMed
  40. Chazaud B (2016) Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise-induced muscle damage management. Immunol Cell Biol 94:140–145 - PubMed
  41. Chen TC, Nosaka K, Tu JH (2007) Changes in running economy following downhill running. J Sports Sci 25:55–63. https://doi.org/10.1080/02640410600718228 - PubMed
  42. Chen TC, Nosaka K, Wu CC (2008) Effects of a 30-min running performed daily after downhill running on recovery of muscle function and running economy. J Sci Med Sport 11:271–279. https://doi.org/10.1016/j.jsams.2007.02.015 - PubMed
  43. Chen TC, Nosaka K, Lin M-J et al (2009) Changes in running economy at different intensities following downhill running. J Sports Sci 27:1137–1144. https://doi.org/10.1080/02640410903062027 - PubMed
  44. Chung HY, Cesari M, Anton S et al (2009) Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 8:18–30 - PubMed
  45. Clarkson PM (1997) Eccentric exercise and muscle damage. Int J Sport Med Suppl. https://doi.org/10.1055/s-2007-972741 - PubMed
  46. Clarkson P, Dedrick M (1988) Exercise-induced muscle damage, repair, and adaptation in old and young subjects. J Gerontol 43:M91–M96. https://doi.org/10.1093/GERONJ/43.4.M91 - PubMed
  47. Clarkson PM, Hubal MJ (2001) Are women less susceptible to exercise-induced muscle damage? Curr Opin Clin Nutr Metab Care 4:527–531 - PubMed
  48. Clarkson PM, Hubal MJ (2002) Exercise-induced muscle damage in humans. Am J Phys Med Rehabil 81:S52–S69 - PubMed
  49. Clarkson PM, Nosaka K, Braun B (1992) Muscle function after exercise-induced muscle damage and rapid adaptation. Med Sci Sports Exerc 24:512–520. https://doi.org/10.1249/00005768-199205000-00004 - PubMed
  50. Cooke MB, Rybalka E, Williams AD et al (2009) Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals. J Int Soc Sports Nutr 6:13. https://doi.org/10.1186/1550-2783-6-13 - PubMed
  51. Cooke MB, Rybalka E, Stathis CG et al (2010) Whey protein isolate attenuates strength decline after eccentrically-induced muscle damage in healthy individuals. J Int Soc Sports Nutr 7:30. https://doi.org/10.1186/1550-2783-7-30 - PubMed
  52. Craddock JC, Neale EP, Peoples GE, Probst YC (2020) Plant-based eating patterns and endurance performance: a focus on inflammation, oxidative stress and immune responses. Nutr Bull 45:123–132. https://doi.org/10.1111/nbu.12427 - PubMed
  53. Cribb PJ, Hayes A (2006) Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy. Med Sci Sports Exerc 38:1918–1925. https://doi.org/10.1249/01.mss.0000233790.08788.3e - PubMed
  54. Damas F, Libardi CA, Ugrinowitsch C (2018) The development of skeletal muscle hypertrophy through resistance training: the role of muscle damage and muscle protein synthesis. Eur J Appl Physiol 118:485–500. https://doi.org/10.1007/s00421-017-3792-9 - PubMed
  55. Dannecker EA, Hausenblas HA, Kaminski TW, Robinson ME (2005) Sex differences in delayed onset muscle pain. Clin J Pain 21:120–126 - PubMed
  56. Dannecker EA, Liu Y, Rector RS et al (2012) Sex differences in exercise-induced muscle pain and muscle damage. J Pain 13:1242–1249. https://doi.org/10.1016/j.jpain.2012.09.014 - PubMed
  57. Dartnall TJ, Nordstrom MA, Semmler JG (2008) Motor unit synchronization is increased in biceps brachii after exercise-induced damage to elbow flexor muscles. J Neurophysiol 99:1008–1019. https://doi.org/10.1152/jn.00686.2007 - PubMed
  58. Davies RW, Carson BP, Jakeman PM (2018) Sex differences in the temporal recovery of neuromuscular function following resistance training in resistance trained menand women 18–35 years. Front Physiol. https://doi.org/10.3389/fphys.2018.01480 - PubMed
  59. Del Valle A, Thomas CK (2005) Firing rates of motor units during strong dynamic contractions. Muscle Nerve 32:316–325. https://doi.org/10.1002/mus.20371 - PubMed
  60. Deminice R, Rosa FT, Franco GS et al (2013) Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans. Nutrition 29:1127–1132. https://doi.org/10.1016/j.nut.2013.03.003 - PubMed
  61. Dinarello CA (2000) Proinflammatory cytokines. Chest 118:503–508. https://doi.org/10.1378/chest.118.2.503 - PubMed
  62. Douglas J, Pearson S, Ross A, McGuigan M (2017) Eccentric exercise: physiological characteristics and acute responses. Sport Med 47:663–675 - PubMed
  63. Enns DL, Tiidus PM (2010) The influence of estrogen on skeletal muscle sex matters. Sport Med 40:41–58 - PubMed
  64. Enoka RM (1996) Eccentric contractions require unique activation strategies by the nervous system. J Appl Physiol 81:2339–2346 - PubMed
  65. Eston RG, Finney S, Baker S, Baltzopoulos V (1996) Muscle tenderness and peak torque changes after downhill running following a prior bout of isokinetic eccentric exercise. J Sports Sci 14:291–299. https://doi.org/10.1080/02640419608727714 - PubMed
  66. Fatouros IG, Jamurtas AZ (2016) Insights into the molecular etiology of exercise-induced inflammation: Opportunities for optimizing performance. J Inflamm Res 9:175–186 - PubMed
  67. Faulkner J, Brooks S, Opiteck J (1993) Injury to skeletal muscle fibers during contractions: conditions of occurrence and prevention. Phys Ther 73:911–921 - PubMed
  68. Féasson L, Stockholm D, Freyssenet D et al (2002) Molecular adaptations of neuromuscular disease-associated proteins in response to eccentric exercise in human skeletal muscle. J Physiol 543:297–306 - PubMed
  69. Febbraio MA, Pedersen BK (2002) Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J 16:1335–2131. https://doi.org/10.1096/fj.01-0876rev - PubMed
  70. Fehrenbach E, Schneider ME (2006) Trauma-induced systemic inflammatory response versus exercise-induced immunomodulatory effects. Sport Med 36:373–384. https://doi.org/10.2165/00007256-200636050-00001 - PubMed
  71. Ferreira DV, Gentil P, Ferreira-Junior JB et al (2017a) Dissociated time course between peak torque and total work recovery following bench press training in resistance trained men. Physiol Behav 179:143–147. https://doi.org/10.1016/j.physbeh.2017.06.001 - PubMed
  72. Ferreira DV, Gentil P, Soares SRS, Bottaro M (2017b) Recovery of pectoralis major and triceps brachii after bench press exercise. Muscle Nerve 56:963–967. https://doi.org/10.1002/mus.25541 - PubMed
  73. Fillingim RB, Maixner W (1995) Gender differences in the responses to noxious stimuli. Pain Forum 4:209–221. https://doi.org/10.1016/s1082-3174(11)80022-x - PubMed
  74. Flann KL, LaStayo PC, McClain DA et al (2011) Muscle damage and muscle remodeling: no pain, no gain? J Exp Biol 214:674LP-679LP. https://doi.org/10.1242/jeb.050112 - PubMed
  75. Flores DF, Gentil P, Brown LE et al (2011) Dissociated time course of recovery between genders after resistance exercise. J Strength Cond Res 25:3039–3044. https://doi.org/10.1519/JSC.0b013e318212dea4 - PubMed
  76. Fournier PA, Bräu L, Ferreira LB et al (2002) Glycogen resynthesis in the absence of food ingestion during recovery from moderate or high intensity physical activity: novel insights from rat and human studies. Comp Biochem Physiol A Mol Integr Physiol 133:755–763. https://doi.org/10.1016/S1095-6433(02)00254-4 - PubMed
  77. Friden J, Sjostrom M, Ekblom B (1983) Myofibrillar damage following intense eccentric exercise in man. Int J Sports Med 4:170–176. https://doi.org/10.1055/s-2008-1026030 - PubMed
  78. Froeling M, Oudeman J, Strijkers GJ et al (2015) Muscle changes detected with diffusion-tensor imaging after long-distance running. Radiology 274:548–562. https://doi.org/10.1148/radiol.14140702 - PubMed
  79. Fulco CS, Rock PB, Muza SR et al (1999) Slower fatigue and faster recovery of the adductor pollicis muscle in women matched for strength with men. Acta Physiol Scand 167:233–239. https://doi.org/10.1046/j.1365-201X.1999.00613.x - PubMed
  80. Gepner Y, Hoffman JR, Shemesh E et al (2017) Combined effect of Bacillus coagulans GBI-30, 6086 and HMB supplementation on muscle integrity and cytokine response during intense military training. J Appl Physiol 123:11–18. https://doi.org/10.1152/japplphysiol.01116.2016 - PubMed
  81. Gibala MJ, MacDougall JD, Tarnopolsky MA et al (1995) Changes in human skeletal muscle ultrastructure and force production after acute resistance exercise. J Appl Physiol 78:702–708. https://doi.org/10.1152/jappl.1995.78.2.702 - PubMed
  82. Gonzalez AM, Stout JR, Jajtner AR et al (2014) Effects of β-hydroxy-β-methylbutyrate free acid and cold water immersion on post-exercise markers of muscle damage. Amino Acids 46:1501–1511. https://doi.org/10.1007/s00726-014-1722-2 - PubMed
  83. Gonzalez AM, Hoffman JR, Stout JR et al (2016) Intramuscular anabolic signaling and endocrine response following resistance exercise: implications for muscle hypertrophy. Sport Med 46:671–685 - PubMed
  84. Gordon JA, Hoffman JR, Arroyo E et al (2017) Comparisons in the recovery response from resistance exercise between young and middle-aged men. J Strength Cond Res 31:3454–3462. https://doi.org/10.1519/JSC.0000000000002219 - PubMed
  85. Goto K, Ishii N, Kizuka T et al (2009) Hormonal and metabolic responses to slow movement resistance exercise with different durations of concentric and eccentric actions. Eur J Appl Physiol 106:731–739. https://doi.org/10.1007/s00421-009-1075-9 - PubMed
  86. Hackney AC, Kallman AL, Aǧgön E (2019) Female sex hormones and the recovery from exercise: menstrual cycle phase affects responses. Biomed Hum Kinet 11:87–89. https://doi.org/10.2478/bhk-2019-0011 - PubMed
  87. Hakkinen K (1993) Neuromuscular fatigue and recovery in male and female athletes during heavy resistance exercise. Int J Sports Med 14:53–59. https://doi.org/10.1055/s-2007-1021146 - PubMed
  88. Hamill J, Freedson PS, Clarkson PM, Braun B (1991) Muscle soreness during running: biomechanical and physiological considerations. Int J Sport Biomech 7:125–137 - PubMed
  89. Harris RC, Tallon MJ, Dunnett M et al (2006) The absorption of orally supplied β-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 30:279–289. https://doi.org/10.1007/s00726-006-0299-9 - PubMed
  90. Harvey KL, Holcomb LE, Kolwicz SC (2019) Ketogenic diets and exercise performance. Nutrients 11:2296 - PubMed
  91. Hatzikotoulas K, Siatras T, Spyropoulou E et al (2004) Muscle fatigue and electromyographic changes are not different in women and men matched for strength. Eur J Appl Physiol 92:298–304. https://doi.org/10.1007/s00421-004-1095-4 - PubMed
  92. Hayashi K, Leary ME, Roy SJ et al (2019) Recovery from strenuous downhill running in young and older physically active adults. Int J Sports Med 40:696–703. https://doi.org/10.1055/a-0951-0017 - PubMed
  93. Heymsfield SB, Arteaga C, McManus CM et al (1983) Measurement of muscle mass in humans: validity of the 24-hour urinary creatinine method. Am J Clin Nutr 37:478–494. https://doi.org/10.1093/ajcn/37.3.478 - PubMed
  94. Highton JM, Twist C, Eston RG (2009) The effects of exercise-induced muscle damage on agility and sprint running performance. J Exerc Sci Fit 7:24–30. https://doi.org/10.1016/S1728-869X(09)60004-6 - PubMed
  95. Hill EC, Housh TJ, Keller JL et al (2018) Early phase adaptations in muscle strength and hypertrophy as a result of low-intensity blood flow restriction resistance training. Eur J Appl Physiol 118:1831–1843. https://doi.org/10.1007/s00421-018-3918-8 - PubMed
  96. Hody S, Croisier J-L, Bury T et al (2019) Eccentric muscle contractions: risks and benefits. Front Physiol 10:536. https://doi.org/10.3389/fphys.2019.00536 - PubMed
  97. Hoffman JR (2016) Creatine and β-alanine supplementation in srtength/power athletes. Curr Top Nutraceuticals Res 8:19–32 - PubMed
  98. Hoffman JR (2019) Dietary supplementation in sport and exercise evidence safety and ergogenic benefits. Routledge, London - PubMed
  99. Hoffman JR, Falvo MJ (2004) Protein—which is best? J Sport Sci Med 3:118–130 - PubMed
  100. Hoffman JR, Nusse V, Kang J (2003) The effect of an intercollegiate soccer game on maximal power performance. Can J Appl Physiol 28:807–817. https://doi.org/10.1139/h03-060 - PubMed
  101. Hoffman JR, Ratamess NA, Kang J et al (2007) Effects of protein supplementation on muscular performance and resting hormonal changes in college football players. J Sport Sci Med 6:85–92 - PubMed
  102. Hoffman JR, Ratamess NA, Tranchina CP et al (2010) Effect of a proprietary protein supplement on recovery indices following resistance exercise in strength/power athletes. Amino Acids 38:771–778. https://doi.org/10.1007/s00726-009-0283-2 - PubMed
  103. Hoffman JR, Ostfeld I, Stout JR et al (2015) β-alanine supplemented diets enhance behavioral resilience to stress exposure in an animal model of PTSD. Amino Acids 47:1247–1257. https://doi.org/10.1007/s00726-015-1952-y - PubMed
  104. Hoffman JR, Gepner Y, Stout JR et al (2016) β-Hydroxy-β-methylbutyrate attenuates cytokine response during sustained military training. Nutr Res 36:553–563. https://doi.org/10.1016/j.nutres.2016.02.006 - PubMed
  105. Hoffman JR, Zuckerman A, Ram O et al (2017) Behavioral and inflammatory response in animals exposed to a low-pressure blast wave and supplemented with β-alanine. Amino Acids 49:871–886. https://doi.org/10.1007/s00726-017-2383-8 - PubMed
  106. Hoffman JR, Varanoske A, Stout JR (2018) Effects of β-alanine supplementation on carnosine elevation and physiological performance. In: Toldra F, Advances in food and nutrition research, 1st edn. Academic Press Inc 84:183–206 - PubMed
  107. Hotfiel T, Freiwald J, Hoppe MW et al (2018) Advances in delayed-onset muscle soreness (DOMS): part I: pathogenesis and diagnostics. Sportverletz Sportschaden 32:243–250. https://doi.org/10.1055/a-0753-1884 - PubMed
  108. Howell JN, Fuglevand AJ, Walsh ML, Bigland-Ritchie B (1995) Motor unit activity during isometric and concentric-eccentric contractions of the human first dorsal interosseus muscle. J Neurophysiol 74:901–904. https://doi.org/10.1152/jn.1995.74.2.901 - PubMed
  109. Hulmi JJ, Kovanen V, Selänne H et al (2009) Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression. Amino Acids 37:297–308. https://doi.org/10.1007/s00726-008-0150-6 - PubMed
  110. Hunter I, Smith GA (2007) Preferred and optimal stride frequency, stiffness and economy: changes with fatigue during a 1-h high-intensity run. Eur J Appl Physiol 100:653–661. https://doi.org/10.1007/s00421-007-0456-1 - PubMed
  111. Isner-Horobeti ME, Dufour SP, Vautravers P et al (2013) Eccentric exercise training: modalities, applications and perspectives. Sport Med 43:483–512 - PubMed
  112. Izquierdo M, Ibañez J, Calbet JAL et al (2009) Neuromuscular fatigue after resistance training. Int J Sports Med 30:614–623. https://doi.org/10.1055/s-0029-1214379 - PubMed
  113. Jäger R, Kerksick CM, Campbell BI et al (2017) International society of sports nutrition position stand: protein and exercise. J Int Soc Sports Nutr 14:20. https://doi.org/10.1186/s12970-017-0177-8 - PubMed
  114. Jajtner AR, Hoffman JR, Townsend JR et al (2016) The effect of polyphenols on cytokine and granulocyte response to resistance exercise. Physiol Rep. https://doi.org/10.14814/phy2.13058 - PubMed
  115. Jajtner AR, Townsend JR, Beyer KS et al (2018) Resistance exercise selectively mobilizes monocyte subsets. Med Sci Sport Exerc 50:2231–2241. https://doi.org/10.1249/MSS.0000000000001703 - PubMed
  116. Jakeman JR, Byrne C, Eston RG (2010) Lower limb compression garment improves recovery from exercise-induced muscle damage in young, active females. Eur J Appl Physiol 109:1137–1144. https://doi.org/10.1007/s00421-010-1464-0 - PubMed
  117. Jansson E, Sylvén C (1985) Creatine kinase MB and citrate synthase in type I and type II muscle fibres in trained and untrained men. Eur J Appl Physiol Occup Physiol 54:207–209. https://doi.org/10.1007/BF02335931 - PubMed
  118. Jones AM, Carter H (2000) The effect of endurance training on parameters of aerobic fitness. Sport Med 29:373–386. https://doi.org/10.2165/00007256-200029060-00001 - PubMed
  119. Jones DA, Newham DJ, Torgan C (1989) Mechanical influences on long-lasting human muscle fatigue and delayed-onset pain. J Physiol 412:415–427. https://doi.org/10.1113/jphysiol.1989.sp017624 - PubMed
  120. Jówko E, Sacharuk J, Balasinska B et al (2012) Effect of a single dose of green tea polyphenols on the blood markers of exercise-induced oxidative stress in soccer players. Int J Sport Nutr Exerc Metab 22:486–496. https://doi.org/10.1123/ijsnem.22.6.486 - PubMed
  121. Joyner MJ, Coyle EF (2008) Endurance exercise performance: the physiology of champions. J Physiol 586:35–44. https://doi.org/10.1113/jphysiol.2007.143834 - PubMed
  122. Kayani AC, Morton JP, McArdle A (2008) The exercise-induced stress response in skeletal muscle: failure during aging. Appl Physiol Nutr Metab 33:1033–1041. https://doi.org/10.1139/h08-089 - PubMed
  123. Kennedy RA, Drake D (2018) Dissociated time course of recovery between strength and power after isoinertial resistance loading in rugby union players. J Strength Cond Res 32:748–755. https://doi.org/10.1519/jsc.0000000000001821 - PubMed
  124. Kerksick CM, Kreider RB, Willoughby DS (2010) Intramuscular adaptations to eccentric exercise and antioxidant supplementation. Amino Acids 39:219–232. https://doi.org/10.1007/s00726-009-0432-7 - PubMed
  125. Kim MK, Cho SW, Park YK (2012) Long-term vegetarians have low oxidative stress, body fat, and cholesterol levels. Nutr Res Pract 6:155–161. https://doi.org/10.4162/nrp.2012.6.2.155 - PubMed
  126. Klemt C, Simeone FJ, Melnic CM et al (2020) MARS MRI assessment of fatty degeneration of the gluteal muscles in patients with THA: reliability and accuracy of commonly used classification systems. Skelet Radiol. https://doi.org/10.1007/s00256-020-03611-9 - PubMed
  127. Kohen R, Yamamoto Y, Cundy KC, Ames BN (1988) Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci USA 85:3175–3179. https://doi.org/10.1073/pnas.85.9.3175 - PubMed
  128. Komulainen J, Koskinen SOA, Kalliokoski R et al (1999) Gender differences in skeletal muscle fibre damage after eccentrically biased downhill running in rats. Acta Physiol Scand 165:57–63. https://doi.org/10.1046/j.1365-201x.1999.00481.x - PubMed
  129. Koutnik AP, D’Agostino DP, Egan B (2019) Anticatabolic effects of ketone bodies in skeletal muscle. Trends Endocrinol Metab 30:227–229 - PubMed
  130. Kraemer RR, Durand RJ, Hollander DB et al (2004) Ghrelin and other glucoregulatory hormone responses to eccentric and concentric muscle contractions. Endocrine 24:93–98. https://doi.org/10.1385/endo:24:1:093 - PubMed
  131. Kraemer WJ, Ratamess NA, Volek JS et al (2006) The effects of amino acid supplementation on hormonal responses to resistance training overreaching. Metabolism 55:282–291. https://doi.org/10.1016/j.metabol.2005.08.023 - PubMed
  132. Kreider RB, Kalman DS, Antonio J et al (2017) International society of sports nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr 14:1–18 - PubMed
  133. Krisanda JM, Moreland TS, Kushmerick MJ (1988) ATP supply and demand during exercise. In: Horton ES, Terjung RL (eds). Exerc Nutr energy Metab. New York: McMillan, pp 27–44 - PubMed
  134. Kyrolainen H, Pullinen T, Candau R et al (2000) Effects of marathon running on running economy and kinematics. Eur J Appl Physiol 82:297–304. https://doi.org/10.1007/s004210000219 - PubMed
  135. Lamb G (2009) Mechanisms of excitation–contraction coupling relevant to activity-induced muscle fatigue. Appl Physiol Nutr Metab 34:368–372. https://doi.org/10.1139/H09-032 - PubMed
  136. Lavender AP, Nosaka K (2006) Changes in fluctuation of isometric force following eccentric and concentric exercise of the elbow flexors. Eur J Appl Physiol 96:235–240. https://doi.org/10.1007/s00421-005-0069-5 - PubMed
  137. Lavin KM, Perkins RK, Jemiolo B et al (2020) Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation. J Appl Physiol 128:87–99. https://doi.org/10.1152/japplphysiol.00495.2019 - PubMed
  138. Lewis PB, Ruby D, Bush-Joseph CA (2012) Muscle Soreness and delayed-onset muscle soreness. Clin Sports Med 31:255–262. https://doi.org/10.1016/j.csm.2011.09.009 - PubMed
  139. Lieber RL, Friden J (1993) Muscle damage is not a function of muscle force but active muscle strain. J Appl Physiol 74:520–526. https://doi.org/10.1152/jappl.1993.74.2.520 - PubMed
  140. Ma S, Huang Q, Yada K et al (2018) An 8-week ketogenic low carbohydrate, high fat diet enhanced exhaustive exercise capacity in mice. Nutrients. https://doi.org/10.3390/nu10060673 - PubMed
  141. MacDougall JD, Ray S, Sale DG et al (1999) Muscle substrate utilization and lactate production during weightlifting. Can J Appl Physiol 24:209–215. https://doi.org/10.1139/h99-017 - PubMed
  142. Macgregor LJ, Hunter AM (2018) High-threshold motor unit firing reflects force recovery following a bout of damaging eccentric exercise. PLoS One 13:e0195051. https://doi.org/10.1371/journal.pone.0195051 - PubMed
  143. Malm C, Sjödin B, Sjöberg B et al (2004) Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running. J Physiol 556:983–1000. https://doi.org/10.1113/jphysiol.2003.056598 - PubMed
  144. Manach C, Scalbert A, Morand C et al (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79:727–747 - PubMed
  145. Marcora SM, Bosio A (2007) Effect of exercise-induced muscle damage on endurance running performance in humans. Scand J Med Sci Sport 17:662–671. https://doi.org/10.1111/j.1600-0838.2006.00627.x - PubMed
  146. Marqueste T, Giannesini B, Le FY et al (2008) Comparative MRI analysis of T2 changes associated with single and repeated bouts of downhill running leading to eccentric-induced muscle damage. J Appl Physiol 105:299–307. https://doi.org/10.1152/japplphysiol.00738.2007 - PubMed
  147. Massicotte D, Scotto A, Péronnet F et al (2006) Metabolic fate of a large amount of 13C-glycerol ingested during prolonged exercise. Eur J Appl Physiol 96:322–329. https://doi.org/10.1007/s00421-005-0058-8 - PubMed
  148. Mateescu RG, Garmyn AJ, O’Neil MA et al (2012) Genetic parameters for carnitine, creatine, creatinine, carnosine, and anserine concentration in longissimus muscle and their association with palatability traits in angus cattle. J Anim Sci 90:4248–4255. https://doi.org/10.2527/jas.2011-5077 - PubMed
  149. McHugh MP (2003) Recent advances in the understanding of the repeated bout effect: the protective effect against muscle damage from a single bout of eccentric exercise. Scand J Med Sci Sport 13:88–97. https://doi.org/10.1034/j.1600-0838.2003.02477.x - PubMed
  150. McHugh MP, Connolly DAJ, Eston RG, Gleim GW (1999) Exercise-induced muscle damage and potential mechanisms for the repeated bout effect. Sport Med 27:157–170 - PubMed
  151. Mckinnon NB, Graham MT, Tiidus PM (2012) Effect of creatine supplementation on muscle damage and repair following eccentrically-induced damage to the elbow flexor muscles. J Sport Sci Med 11:653–659 - PubMed
  152. McPherson PAC, McEneny J (2012) The biochemistry of ketogenesis and its role in weight management, neurological disease and oxidative stress. J Physiol Biochem 68:141–151 - PubMed
  153. Meeusen R, Duclos M, Foster C et al (2013) Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the european college of sport science and the American College of Sports Medicine. Med Sci Sports Exerc 45:186–205. https://doi.org/10.1249/MSS.0b013e318279a10a - PubMed
  154. Milder J, Patel M (2012) Modulation of oxidative stress and mitochondrial function by the ketogenic diet. Epilepsy Res 100:295–303. https://doi.org/10.1016/j.eplepsyres.2011.09.021 - PubMed
  155. Millet GY, Lepers R (2004) Alterations of neuromuscular function after prolonged running, cycling and skiing exercises. Sport Med 34:105–116 - PubMed
  156. Millet GY, Tomazin K, Verges S et al (2011) Neuromuscular consequences of an extreme mountain ultra-marathon. PLoS One. https://doi.org/10.1371/journal.pone.0017059 - PubMed
  157. Molina R, Denadai BS (2012) Dissociated time course recovery between rate of force development and peak torque after eccentric exercise. Clin Physiol Funct Imaging 32:179–184. https://doi.org/10.1111/j.1475-097X.2011.01074.x - PubMed
  158. Morawetz D, Blank C, Koller A et al (2020) Sex-related differences after a single bout of maximal eccentric exercise in response to acute effects: a systematic review and meta-analysis. J Strength Cond Res. https://doi.org/10.1519/JSC.0000000000002867 - PubMed
  159. Morifuji M, Sakai K, Sanbongi C, Sugiura K (2005) Dietary whey protein increases liver and skeletal muscle glycogen levels in exercise-trained rats. Br J Nutr 93:439–445. https://doi.org/10.1079/bjn20051373 - PubMed
  160. Murakami T, Furuse M (2010) The impact of taurine-and beta-alanine-supplemented diets on behavioral and neurochemical parameters in mice: antidepressant versus anxiolytic-like effects. Amino Acids 39:427–434. https://doi.org/10.1007/s00726-009-0458-x - PubMed
  161. Murase S, Terazawa E, Hirate K et al (2013) Upregulated glial cell line-derived neurotrophic factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats. J Physiol 591:3035–3048. https://doi.org/10.1113/jphysiol.2012.249235 - PubMed
  162. Nardone A, Romanò C, Schieppati M (1989) Selective recruitment of high-threshold human motor units during voluntary isotonic lengthening of active muscles. J Physiol 409:451–471. https://doi.org/10.1113/jphysiol.1989.sp017507 - PubMed
  163. Nebl J, Drabert K, Haufe S et al (2019) Exercise-induced oxidative stress, nitric oxide and plasma amino acid profile in recreational runners with vegetarian and non-vegetarian dietary patterns. Nutrients. https://doi.org/10.3390/nu11081875 - PubMed
  164. Nelson A, Arnall D, Kokkonen J et al (2001) Muscle glycogen supercompensation is enhanced by prior creatine supplementation. Med Sci Sport Exerc 33:1096–1100. https://doi.org/10.1097/00005768-200107000-00005 - PubMed
  165. Neubauer O, Sabapathy S, Lazarus R et al (2013) Transcriptome analysis of neutrophils after endurance exercise reveals novel signaling mechanisms in the immune response to physiological stress. J Appl Physiol 114:1677–1688. https://doi.org/10.1152/japplphysiol.00143.2013 - PubMed
  166. Newham DJ, McPhail G, Mills KR, Edwards RHT (1983) Ultrastructural changes after concentric and eccentric contractions of human muscle. J Neurol Sci 61:109–122. https://doi.org/10.1016/0022-510X(83)90058-8 - PubMed
  167. Newham DJ, Jones DA, Clarkson PM (1987) Repeated high-force eccentric exercise: effects on muscle pain and damage. J Appl Physiol 63:1381–1386. https://doi.org/10.1152/jappl.1987.63.4.1381 - PubMed
  168. Newton MJ, Morgan GT, Sacco P et al (2008) Comparison of responses to strenuous eccentric exercise of the elbow flexors between resistance-trained and untrained men. J Strength Cond Res 22:597–607. https://doi.org/10.1519/JSC.0b013e3181660003 - PubMed
  169. Nieman DC, Henson DA, Davis JM et al (2007) Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States endurance run. J Interferon Cytokine Res 27:1003–1011. https://doi.org/10.1089/jir.2007.0050 - PubMed
  170. Nishimura A, Sugita M, Kato K et al (2010) Hypoxia increases muscle hypertrophy induced by resistance training. Int J Sports Physiol Perform 5:497–508. https://doi.org/10.1123/ijspp.5.4.497 - PubMed
  171. Nosaka K, Sakamoto K, Newton M, Sacco P (2001) How long does the protective effect on eccentric exercise-induced muscle damage last? Med Sci Sports Exerc 33:1490–1495. https://doi.org/10.1097/00005768-200109000-00011 - PubMed
  172. Nosaka K, Newton M, Sacco P (2002a) Delayed-onset muscle soreness does not reflect the magnitude of eccentric exercise-induced muscle damage. Scand J Med Sci Sports 12:337–346. https://doi.org/10.1034/j.1600-0838.2002.10178.x - PubMed
  173. Nosaka K, Newton M, Sacco P (2002b) Muscle damage and soreness after endurance exercise of the elbow flexors. Med Sci Sports Exerc 34:920–927. https://doi.org/10.1097/00005768-200206000-00003 - PubMed
  174. Opal SM, Depalo VA (2000) Anti-inflammatory cytokines. Chest 117:1162–1172 - PubMed
  175. Ostrowski K, Hermann C, Bangash A et al (1998) A trauma-like elevation of plasma cytokines in humans in response to treadmill running. J Physiol 513:889–894. https://doi.org/10.1111/j.1469-7793.1998.889ba.x - PubMed
  176. Oudeman J, Nederveen AJ, Strijkers GJ et al (2016) Techniques and applications of skeletal muscle diffusion tensor imaging: a review. J Magn Reson Imaging 43:773–788. https://doi.org/10.1002/jmri.25016 - PubMed
  177. Owens DJ, Twist C, Cobley JN et al (2018) What is it, what causes it and what are the nutritional solutions? Eur J Sport Sci 19:71–85. https://doi.org/10.1080/17461391.2018.1505957 - PubMed
  178. Panza VSP, Wazlawik E, Ricardo Schütz G et al (2008) Consumption of green tea favorably affects oxidative stress markers in weight-trained men. Nutrition 24:433–442. https://doi.org/10.1016/j.nut.2008.01.009 - PubMed
  179. Paoli A, Bianco A, Grimaldi KA (2015) The ketogenic diet and sport: a possible marriage? Exerc Sport Sci Rev 43:153–162. https://doi.org/10.1249/JES.0000000000000050 - PubMed
  180. Paulsen G, Egner IM, Drange M et al (2010) A COX-2 inhibitor reduces muscle soreness, but does not influence recovery and adaptation after eccentric exercise. Scand J Med Sci Sports 20:e195–e207. https://doi.org/10.1111/j.1600-0838.2009.00947.x - PubMed
  181. Paulsen G, Mikkelsen UR, Raastad T, Peake JM (2012) Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise? Exerc Immunol Rev 18:42–97 - PubMed
  182. Paulus J, Croisier J-L, Kaux J-F, Bury T (2019) Eccentric versus concentric—which is the most stressful cardiovascularly and metabolically? Curr Sports Med Rep 18:477–489. https://doi.org/10.1249/JSR.0000000000000666 - PubMed
  183. Peake JM (2019) Recovery after exercise: what is the current state of play? Curr Opin Physiol 10:17–26. https://doi.org/10.1016/j.cophys.2019.03.007 - PubMed
  184. Peake J, Wilson G, Hordern M et al (2004) Changes in neutrophil surface receptor expression, degranulation, and respiratory burst activity after moderate- and high-intensity exercise. J Appl Physiol 97:612–618. https://doi.org/10.1152/japplphysiol.01331.2003 - PubMed
  185. Peake JM, Suzuki K, Hordern M et al (2005) Plasma cytokine changes in relation to exercise intensity and muscle damage. Eur J Appl Physiol 95:514–521. https://doi.org/10.1007/s00421-005-0035-2 - PubMed
  186. Peake JM et al (2005) Plasma cytokine changes in relation to exercise intensity and muscle damage. Eur J Appl Physiol 95:514–521. https://doi.org/10.1007/s00421-005-0035-2 - PubMed
  187. Peake JM, Neubauer O, Gatta DP, Nosaka K (2017) Muscle damage and inflammation during recovery from exercise. J Appl Physiol 122:559–570 - PubMed
  188. Pearson SJ, Hussain SR (2015) A review on the mechanisms of blood-flow restriction resistance training-induced muscle hypertrophy. Sport Med 45:187–200 - PubMed
  189. Pedersen BK, Fischer CP (2007) Physiological roles of muscle-derived interleukin-6 in response to exercise. Curr Opin Clin Nutr Metab Care 10:265–271 - PubMed
  190. Pedersen BK, Steensberg A, Schjerling P (2001) Exercise and interleukin-6. Curr Opin Hematol 8:137–141 - PubMed
  191. Piitulainen H, Bottas R, Komi P et al (2010) Impaired action potential conduction at high force levels after eccentric exercise. J Electromyogr Kinesiol 20:879–887. https://doi.org/10.1016/j.jelekin.2009.10.001 - PubMed
  192. Pillon NJ, Bilan PJ, Fink LN, Klip A (2013) Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications. Am J Physiol Endocrinol Metab. https://doi.org/10.1152/ajpendo.00553.2012 - PubMed
  193. Plattner K, Baumeister J, Lamberts R, Lambert M (2011) Dissociation changes in EMG activation during maximal isometric and submaximal low force dynamic contractions after exercise induced muscle damage. J Electromyogr Kinesiol 21:542–550 - PubMed
  194. Pokora I, Kempa K, Chrapusta SJ, Langfort J (2014) Effects of downhill and uphill exercises of equivalent submaximal intensities on selected blood cytokine levels and blood creatine kinase activity. Biol Sport 31:173–178. https://doi.org/10.5604/20831862.1111434 - PubMed
  195. Power GA, Dalton BH, Rice CL, Vandervoort AA (2013) Peak power is reduced following lengthening contractions despite a maintenance of shortening velocity. Appl Physiol Nutr Metab 38:1196–1205. https://doi.org/10.1139/apnm-2013-0092 - PubMed
  196. Prasartwuth O, Allen TJ, Butler JE et al (2006) Length-dependent changes in voluntary activation, maximum voluntary torque and twitch responses after eccentric damage in humans. J Physiol 571:243–252. https://doi.org/10.1113/jphysiol.2005.101600 - PubMed
  197. Prins PJ, Noakes TD, Welton GL et al (2019) High rates of fat oxidation induced by a low-carbohydrate, high-fat diet, do not impair 5-km running performance in competitive recreational athletes. J Sport Sci Med 18:738–750 - PubMed
  198. Quindry J, Miller L, McGinnis G et al (2011) Muscle-fiber type and blood oxidative stress after eccentric exercise. Int J Sport Nutr Exerc Metab 21:462–470. https://doi.org/10.1123/ijsnem.21.6.462 - PubMed
  199. Raastad T, Hallén J (2000) Recovery of skeletal muscle contractility after high- and moderate-intensity strength exercise. Eur J Appl Physiol 82:206–214. https://doi.org/10.1007/s004210050673 - PubMed
  200. Radak Z, Chung H, Koltai E et al (2008) Exercise, oxidative stress and hormesis. Ageing Res Rev 7:34–42. https://doi.org/10.1016/j.arr.2007.04.004 - PubMed
  201. Radunsky D, Blumenfeld-Katzir T, Volovyk O et al (2019) Analysis of magnetization transfer (MT) influence on quantitative mapping of T2 relaxation time. Magn Reson Med 82:145–158. https://doi.org/10.1002/mrm.27704 - PubMed
  202. Raeder C, Wiewelhove T, Westphal-Martinez MP et al (2016) Neuromuscular fatigue and physiological responses after five dynamic squat exercise protocols. J Strength Cond Res 30:953–965. https://doi.org/10.1519/JSC.0000000000001181 - PubMed
  203. Rawson ES, Gunn B, Clarkson PM (2001) The effects of creatine supplementation on exercise-induced muscle damage. J Strength Cond Res 15:178–184 - PubMed
  204. Reis E, Frick U, Schmidtbleicher D (1995) Frequency variations of strength training sessions triggered by the phases of the menstrual cycle. Int J Sports Med 16:545–550. https://doi.org/10.1055/s-2007-973052 - PubMed
  205. Rhyu H, Cho S-Y, Roh H-T (2014) The effects of ketogenic diet on oxidative stress and antioxidative capacity markers of Taekwondo athletes. J Exerc Rehabil 10:362–366. https://doi.org/10.12965/jer.140178 - PubMed
  206. Rinard J, Clarkson PM, Smith LL, Grossman M (2000) Response of males and females to high-force eccentric exercise. J Sports Sci 18:229–236. https://doi.org/10.1080/026404100364965 - PubMed
  207. Roberts PA, Fox J, Peirce N et al (2016) Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24 h of recovery following prolonged exhaustive exercise in humans. Amino Acids 48:1831–1842. https://doi.org/10.1007/s00726-016-2252-x - PubMed
  208. Roig M, O’brien K, Kirk G et al (2009) The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analysis. Br J Sports Med. https://doi.org/10.1136/bjsm.2008.051417 - PubMed
  209. Rooney KJ, Herbert RD, Balnave RJ (1994) Fatigue contributes to the strength training stimulus. Med Sci Sports Exerc 26:1160–1164. https://doi.org/10.1249/00005768-199409000-00014 - PubMed
  210. Santos RV, Bassit RA, Caperuto EC, Costa Rosa LF (2004) The effect of creatine supplementation upon inflammatory and muscle soreness markers after a 30km race. Life Sci. 75(16):1917–1924. https://doi.org/10.1016/j.lfs.2003.11.036 - PubMed
  211. Sayers SP, Clarkson PM (2001) Force recovery after eccentric exercise in males and females. Eur J Appl Physiol 84:122–126. https://doi.org/10.1007/s004210000346 - PubMed
  212. Schoenfeld BJ (2010) The mechanisms of muscle hypertrophy and their application to resistance training. J Strength Cond Res 24:2857–2872 - PubMed
  213. Schoenfeld BJ (2012) Does exercise-induced muscle damage play a role in skeletal muscle hypertrophy? J Strength Cond Res 26:1441–1453 - PubMed
  214. Schoenfeld BJ (2013) Potential mechanisms for a role of metabolic stress in hypertrophic adaptations to resistance training. Sport Med 43:179–194 - PubMed
  215. Sewright KA, Hubal MJ, Kearns A et al (2008) Sex differences in response to maximal eccentric exercise. Med Sci Sport Exerc 40:242–251. https://doi.org/10.1249/mss.0b013e31815aedda - PubMed
  216. Sherman WM, Armstrong LE, Murray TM et al (1984) Effect of a 42.2-km footrace and subsequent rest or exercise on muscular strength and work capacity. J Appl Physiol Respir Environ Exerc Physiol 57:1668–1673. https://doi.org/10.1152/jappl.1984.57.6.1668 - PubMed
  217. Smith LL, McKune AJ, Semple SJ et al (2007) Changes in serum cytokines after repeated bouts of downhill running. Appl Physiol Nutr Metab 32:233–240. https://doi.org/10.1139/H06-106 - PubMed
  218. Smith AE, Stout JR, Kendall KL et al (2012) Exercise-induced oxidative stress: the effects of β-alanine supplementation in women. Amino Acids 43:77–90. https://doi.org/10.1007/s00726-011-1158-x - PubMed
  219. Smith-Ryan AE, Fukuda DH, Stout JR, Kendall KL (2014) The influence of β-alanine supplementation on markers of exercise-induced oxidative stress. Appl Physiol Nutr Metab 39:101–104. https://doi.org/10.1139/apnm-2013-0229 - PubMed
  220. Stupka N, Lowther S, Chorneyko K et al (2000) Gender differences in muscle inflammation after eccentric exercise. J Appl Physiol 89:2325–2332. https://doi.org/10.1152/jappl.2000.89.6.2325 - PubMed
  221. Sudo M, Ando S, Poole DC, Kano Y (2015) Blood flow restriction prevents muscle damage but not protein synthesis signaling following eccentric contractions. Physiol Rep 3:e12449. https://doi.org/10.14814/phy2.12449 - PubMed
  222. Suga T, Okita K, Morita N et al (2009) Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction. J Appl Physiol 106:1119–1124. https://doi.org/10.1152/japplphysiol.90368.2008 - PubMed
  223. Suzuki K, Totsuka M, Nakaji S et al (1999) Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage. J Appl Physiol 87:1360–1367. https://doi.org/10.1152/jappl.1999.87.4.1360 - PubMed
  224. Suzuki K, Tominaga T, Ruhee RT, Ma S (2020) Characterization and modulation of systemic inflammatory response to exhaustive exercise in relation to oxidative stress. Antioxidants. https://doi.org/10.3390/antiox9050401 - PubMed
  225. Szeto YT, Kwok TCY, Benzie IFF (2004) Effects of a long-term vegetarian diet on biomarkers of antioxidant status and cardiovascular disease risk. Nutrition 20:863–866. https://doi.org/10.1016/j.nut.2004.06.006 - PubMed
  226. Takarada Y, Nakamura Y, Aruga S et al (2000) Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion. J Appl Physiol 88:61–65. https://doi.org/10.1152/jappl.2000.88.1.61 - PubMed
  227. Tee JC, Bosch AN, Lambert MI (2007) Metabolic consequences of exercise-induced muscle damage. Sport Med 37:827–836 - PubMed
  228. Thomas DT, Erdman KA, Burke LM (2016) Position of the academy of nutrition and dietetics, dietitians of canada, and the american college of sports medicine: nutrition and athletic performance. J Acad Nutr Diet 116:501–528. https://doi.org/10.1016/j.jand.2015.12.006 - PubMed
  229. Tieland M, Trouwborst I, Clark BC (2018) Skeletal muscle performance and ageing. J Cachexia Sarcopenia Muscle 9:3–19. https://doi.org/10.1002/jcsm.12238 - PubMed
  230. Tiidus PM (1995) Can estrogens diminished exercise induced muscle damage? Can J Appl Physiol 20:26–38. https://doi.org/10.1139/h95-002 - PubMed
  231. Townsend JR, Stout JR, Jajtner AR et al (2018) Polyphenol supplementation alters intramuscular apoptotic signaling following acute resistance exercise. Physiol Rep. https://doi.org/10.14814/phy2.13552 - PubMed
  232. Trombley PQ, Horning MS, Blakemore LJ (2000) Interactions between carnosine and zinc and copper: implications for neuromodulation and neuroprotection. Biochemistry 65:807–816 - PubMed
  233. Urhausen A, Gabriel H, Kindermann W (1995) Blood hormones as markers of training stress and overtraining. Sports Med 20:251–276. https://doi.org/10.2165/00007256-199520040-00004 - PubMed
  234. Van Loon LJC, Murphy R, Oosterlaar AM et al (2004) Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle. Clin Sci 106:99–106. https://doi.org/10.1042/CS20030116 - PubMed
  235. Vanacore D, Messina G, Lama S et al (2018) Effect of restriction vegan diet’s on muscle mass, oxidative status, and myocytes differentiation: a pilot study. J Cell Physiol 233:9345–9353. https://doi.org/10.1002/jcp.26427 - PubMed
  236. Veech RL (2004) The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fat Acids 70:309–319. https://doi.org/10.1016/j.plefa.2003.09.007 - PubMed
  237. Volek JS, Ratamess NA, Rubin MR et al (2004) The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching. Eur J Appl Physiol 91:628–637. https://doi.org/10.1007/s00421-003-1031-z - PubMed
  238. Volek JS, Freidenreich DJ, Saenz C et al (2016) Metabolic characteristics of keto-adapted ultra-endurance runners. Metabolism 65:100–110. https://doi.org/10.1016/j.metabol.2015.10.028 - PubMed
  239. Warren GL, Lowe DA, Armstrong RB (1999) Measurement tools used in the study of eccentric contraction-induced injury. Sport Med 27:43–59. https://doi.org/10.2165/00007256-199927010-00004 - PubMed
  240. Webb R, Hughes MG, Thomas AW, Morris K (2017) The ability of exercise-associated oxidative stress to trigger redox-sensitive signalling responses. Antioxidants (Basel, Switzerland) 6:63. https://doi.org/10.3390/antiox6030063 - PubMed
  241. Wikström-Frisén L, Boraxbekk CJ, Henriksson-Larsén K (2017) Effects on power, strength and lean body mass of menstrual/oral contraceptive cycle based resistance training. J Sports Med Phys Fit 57:43–52. https://doi.org/10.23736/S0022-4707.16.05848-5 - PubMed

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