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Showing 1 to 12 of 2886 entries
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Endoscopic Therapy in Inflammatory Bowel Diseases.

Viszeralmedizin

Neumann H, Neurath MF, Atreya R.
PMID: 26557837
Viszeralmedizin. 2015 Aug;31(4):280-6. doi: 10.1159/000435851. Epub 2015 Aug 04.

BACKGROUND: Endoscopy is an essential diagnostic and therapeutic modality in the clinical care of inflammatory bowel disease (IBD) patients. Endoscopic therapy can be used for treatment of disease-related strictures, surveillance and resection of intraepithelial neoplasia, and treatment of fistulas...

Identification of Non-Coding RNAs in the Candida parapsilosis Species Group.

PloS one

Donovan PD, Schröder MS, Higgins DG, Butler G.
PMID: 27658249
PLoS One. 2016 Sep 22;11(9):e0163235. doi: 10.1371/journal.pone.0163235. eCollection 2016.

The Candida CTG clade is a monophyletic group of fungal species that translates CTG as serine, and includes the pathogens Candida albicans and Candida parapsilosis. Research has typically focused on identifying protein-coding genes in these species. Here, we use...

Synthesis of Spirocyclohexadienones through Radical Cascade Reactions Featuring 3-Fold Carbon-Carbon Bond Formation.

Organic letters

Hegmann N, Prusko L, Heinrich MR.
PMID: 28472891
Org Lett. 2017 May 05;19(9):2222-2225. doi: 10.1021/acs.orglett.7b00676. Epub 2017 Apr 20.

The radical 5-exo cyclization starting from 2-allyloxyphenyldiazonium ions can be employed for the diastereoselective synthesis of ortho-spirocyclohexadienones through a consecutive addition to alkynes. The spirocyclic systems are formed in a radical [2 + 2 + 1] cycloaddition comprising three...

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.

JCI insight

Kienhöfer D, Hahn J, Stoof J, Csepregi JZ, Reinwald C, Urbonaviciute V, Johnsson C, Maueröder C, Podolska MJ, Biermann MH, Leppkes M, Harrer T, Hultqvist M, Olofsson P, Munoz LE, Mocsai A, Herrmann M, Schett G, Holmdahl R, Hoffmann MH.
PMID: 28515366
JCI Insight. 2017 May 18;2(10). doi: 10.1172/jci.insight.92920. eCollection 2017 May 18.

Many effector mechanisms of neutrophils have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Neutrophil extracellular traps (NETs) have been assigned a particularly detrimental role. Here we investigated the functional impact of neutrophils and NETs on a...

Biocrystallography in Switzerland: Achievements and Future Perspectives.

Chimia

Grütter MG.
PMID: 28982439
Chimia (Aarau). 2014 Feb 26;68(1):54-59. doi: 10.2533/chimia.2014.54.

The first protein crystallography group in Switzerland was installed at the Biozentrum of the University of Basel approximately 40 years ago. Since then protein crystallography has grown and matured remarkably and is now established in the molecular biology, biochemistry...

Isolation and detection of circulating tumour cells from metastatic melanoma patients using a slanted spiral microfluidic device.

Oncotarget

Aya-Bonilla CA, Marsavela G, Freeman JB, Lomma C, Frank MH, Khattak MA, Meniawy TM, Millward M, Warkiani ME, Gray ES, Ziman M.
PMID: 28978038
Oncotarget. 2017 Jun 27;8(40):67355-67368. doi: 10.18632/oncotarget.18641. eCollection 2017 Sep 15.

Circulating Tumour Cells (CTCs) are promising cancer biomarkers. Several methods have been developed to isolate CTCs from blood samples. However, the isolation of melanoma CTCs is very challenging as a result of their extraordinary heterogeneity, which has hindered their...

Neuroendocrine tumor of the pancreas with cystic appearance mimicking a progressive intraductal papillary mucinous neoplasm: pitfall in medical imaging.

Endoscopy

Vitali F, Strobel D, Pfeifer L, Heinrich M, Wachter D, Neurath MF, Wildner D.
PMID: 27669533
Endoscopy. 2016 0;48:E302-E303. doi: 10.1055/s-0042-116820. Epub 2016 Sep 26.

No abstract available.

Truncated and modified amyloid-beta species.

Alzheimer's research & therapy

Kummer MP, Heneka MT.
PMID: 25031638
Alzheimers Res Ther. 2014 May 26;6(3):28. doi: 10.1186/alzrt258. eCollection 2014.

Alzheimer's disease pathology is closely connected to the processing of the amyloid precursor protein (APP) resulting in the formation of a variety of amyloid-beta (Aβ) peptides. They are found as insoluble aggregates in senile plaques, the histopathological hallmark of...

Cortical hot spots and labyrinths: why cortical neuromodulation for episodic migraine with aura should be personalized.

Frontiers in computational neuroscience

Dahlem MA, Schmidt B, Bojak I, Boie S, Kneer F, Hadjikhani N, Kurths J.
PMID: 25798103
Front Comput Neurosci. 2015 Mar 05;9:29. doi: 10.3389/fncom.2015.00029. eCollection 2015.

Stimulation protocols for medical devices should be rationally designed. For episodic migraine with aura we outline model-based design strategies toward preventive and acute therapies using stereotactic cortical neuromodulation. To this end, we regard a localized spreading depression (SD) wave...

The immune response after fracture trauma is different in old compared to young patients.

Immunity & ageing : I & A

Vester H, Huber-Lang MS, Kida Q, Scola A, van Griensven M, Gebhard F, Nüssler AK, Perl M.
PMID: 25620994
Immun Ageing. 2014 Dec 11;11(1):20. doi: 10.1186/s12979-014-0020-x. eCollection 2014.

BACKGROUND: Despite significant medical progress and improved treatment, surgical procedures of proximal femur fractures in older patients are still associated with a high postoperative complication and mortality rate. Recently, several authors investigated the phenomenon of immunoageing, indicating differences in...

Origami: Folding creases through bending.

Nature materials

Al-Mulla T, Buehler MJ.
PMID: 25801402
Nat Mater. 2015 Apr;14(4):366-8. doi: 10.1038/nmat4258.

No abstract available.

Using Voice Coils to Actuate Modular Soft Robots: Wormbot, an Example.

Soft robotics

Nemitz MP, Mihaylov P, Barraclough TW, Ross D, Stokes AA.
PMID: 28078195
Soft Robot. 2016 Dec 01;3(4):198-204. doi: 10.1089/soro.2016.0009.

In this study, we present a modular worm-like robot, which utilizes voice coils as a new paradigm in soft robot actuation. Drive electronics are incorporated into the actuators, providing a significant improvement in self-sufficiency when compared with existing soft...

Showing 1 to 12 of 2886 entries