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Chambraud B, Daguinot C, Guillemeau K, et al. Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress. Autophagy. 2021;17(11):3491-3510doi: 10.1080/15548627.2021.1875611.
Chambraud, B., Daguinot, C., Guillemeau, K., Genet, M., Dounane, O., Meduri, G., Poüs, C., Baulieu, E. E., & Giustiniani, J. (2021). Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress. Autophagy, 17(11), 3491-3510. https://doi.org/10.1080/15548627.2021.1875611
Chambraud, Béatrice, et al. "Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress." Autophagy vol. 17,11 (2021): 3491-3510. doi: https://doi.org/10.1080/15548627.2021.1875611
Chambraud B, Daguinot C, Guillemeau K, Genet M, Dounane O, Meduri G, Poüs C, Baulieu EE, Giustiniani J. Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress. Autophagy. 2021 Nov;17(11):3491-3510. doi: 10.1080/15548627.2021.1875611. Epub 2021 Jan 25. PMID: 33459145; PMCID: PMC8632305.
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Autophagy. 2021 Nov;17(11):3491-3510. doi: 10.1080/15548627.2021.1875611. Epub 2021 Jan 25.

Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.

Autophagy

Béatrice Chambraud, Corentin Daguinot, Kevin Guillemeau, Melanie Genet, Omar Dounane, Geri Meduri, Christian Poüs, Etienne Emile Baulieu, Julien Giustiniani

Affiliations

  1. INSERM U1195, Université Paris-Saclay, Kremlin-Bicêtre, France.
  2. INSERM UMR-S-1193, Université Paris-Saclay, Châtenay-Malabry, France.
  3. Biochimie-Hormonologie , AP-HP Université Paris-Saclay, Site Antoine Béclère, Clamart, France.

PMID: 33459145 PMCID: PMC8632305 DOI: 10.1080/15548627.2021.1875611

Abstract

Defects of autophagy-lysosomal protein degradation are thought to contribute to the pathogenesis of several neurodegenerative diseases, and the accumulation of aggregation prone proteins such as MAPT/Tau in Alzheimer disease (AD). We previously showed the localization of the immunophilin FKBP4/FKBP52 in the lysosomal system of healthy human neurons suggesting its possible role in lysosome function. We also showed that decreased FKBP4 levels in AD brain neurons correlate with abnormal MAPT accumulation and aggregation. In this study, we demonstrate that FKBP4 decrease in a human neuronal cell line (SH-SY5Y) and in dorsal root ganglion (DRG) neurons from human MAPT

Keywords: Alzheimer disease; FKBP52; Tau; autophagy; lysosomes; proteotoxic stress

References

  1. J Cell Biol. 2010 Feb 22;188(4):527-36 - PubMed
  2. J Mol Biol. 2020 Jan 3;432(1):53-62 - PubMed
  3. J Cell Sci. 2013 Mar 1;126(Pt 5):1071-80 - PubMed
  4. Aging Cell. 2018 Feb;17(1): - PubMed
  5. J Alzheimers Dis. 2014;40 Suppl 1:S47-70 - PubMed
  6. Biochim Biophys Acta. 2015 Oct;1850(10):2005-16 - PubMed
  7. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9034-8 - PubMed
  8. Autophagy. 2020 Apr;16(4):641-658 - PubMed
  9. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2658-63 - PubMed
  10. Trends Cell Biol. 2017 Mar;27(3):230-240 - PubMed
  11. J Cell Biol. 2010 Feb 22;188(4):537-46 - PubMed
  12. J Biol Chem. 2009 May 8;284(19):12845-52 - PubMed
  13. Cell. 2011 Sep 2;146(5):682-95 - PubMed
  14. J Neurochem. 2002 Nov;83(3):481-9 - PubMed
  15. Acta Neuropathol. 1991;82(4):239-59 - PubMed
  16. Neurodegener Dis. 2012;10(1-4):73-5 - PubMed
  17. J Cell Biol. 1998 Apr 6;141(1):51-9 - PubMed
  18. Science. 2013 May 3;340(6132):559-61 - PubMed
  19. Neurobiol Aging. 1997 Jul-Aug;18(4 Suppl):S1-2 - PubMed
  20. Nat Med. 2015 Dec;21(12):1406-15 - PubMed
  21. J Alzheimers Dis. 2012;29(2):471-83 - PubMed
  22. Int J Biochem Cell Biol. 2005 Jan;37(1):42-7 - PubMed
  23. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9535-40 - PubMed
  24. Curr Top Dev Biol. 2006;76:89-101 - PubMed
  25. Nat Cell Biol. 2009 Jul;11(7):909-13 - PubMed
  26. Cold Spring Harb Perspect Med. 2012 Aug 01;2(8): - PubMed
  27. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11197-201 - PubMed
  28. FASEB J. 2015 Aug;29(8):3171-81 - PubMed
  29. J Neurosci. 2002 Nov 1;22(21):9340-51 - PubMed
  30. PLoS One. 2009;4(3):e4843 - PubMed
  31. J Cell Biol. 2019 Apr 1;218(4):1118-1127 - PubMed
  32. Traffic. 2018 Oct;19(10):761-769 - PubMed
  33. Cell. 2011 Nov 11;147(4):728-41 - PubMed
  34. Cell. 2016 Jun 30;166(1):152-66 - PubMed
  35. Acta Neuropathol Commun. 2014 Jan 30;2:14 - PubMed
  36. J Neurosci. 2013 Nov 13;33(46):18175-89 - PubMed
  37. Mol Cell Biol. 2014 Apr;34(7):1336-48 - PubMed
  38. Mol Cell Biol. 2008 Sep;28(18):5747-63 - PubMed
  39. J Biol Chem. 2005 Feb 11;280(6):4609-16 - PubMed
  40. Neuron. 2014 Jun 18;82(6):1271-88 - PubMed
  41. Nature. 2008 Feb 28;451(7182):1069-75 - PubMed
  42. Autophagy. 2016;12(1):1-222 - PubMed
  43. EMBO Rep. 2017 Jun;18(6):947-961 - PubMed
  44. Elife. 2015 Nov 02;4: - PubMed
  45. J Cell Biol. 2016 Mar 14;212(6):677-92 - PubMed
  46. Nat Cell Biol. 2011 Apr;13(4):453-60 - PubMed
  47. J Biol Chem. 2007 Aug 17;282(33):24131-45 - PubMed
  48. Cell Res. 2010 Jul;20(7):748-62 - PubMed
  49. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4584-9 - PubMed
  50. J Biol Chem. 2004 May 21;279(21):22483-9 - PubMed
  51. Autophagy. 2019 Feb;15(2):341-346 - PubMed
  52. Eur J Neurosci. 2008 Mar;27(5):1119-30 - PubMed
  53. Hum Mol Genet. 2014 Oct 1;23(19):5102-8 - PubMed
  54. BMC Res Notes. 2016 Feb 11;9:82 - PubMed
  55. EMBO J. 2016 Jul 15;35(14):1537-49 - PubMed
  56. Autophagy. 2013 May;9(5):667-82 - PubMed
  57. Sci Rep. 2014 Jul 17;4:5715 - PubMed
  58. Science. 1996 Dec 6;274(5293):1715-7 - PubMed
  59. Curr Opin Neurobiol. 2018 Aug;51:29-36 - PubMed
  60. Proc Natl Acad Sci U S A. 1975 May;72(5):1858-62 - PubMed
  61. Physiol Rev. 2004 Apr;84(2):361-84 - PubMed
  62. Hum Mol Genet. 2009 Nov 1;18(21):4153-70 - PubMed
  63. Genes Dev. 2008 Jun 1;22(11):1427-38 - PubMed
  64. Autophagy. 2019 Oct;15(10):1682-1693 - PubMed
  65. Neurobiol Aging. 2016 Oct;46:124-37 - PubMed
  66. Autophagy. 2010 Jan;6(1):182-3 - PubMed
  67. Biochem J. 2016 Oct 15;473(20):3517-3532 - PubMed
  68. Nature. 2003 Dec 18;426(6968):895-9 - PubMed
  69. Arch Neurol. 2004 Mar;61(3):378-84 - PubMed
  70. Autophagy. 2011 Mar;7(3):279-96 - PubMed
  71. Nature. 1990 Aug 30;346(6287):864-6 - PubMed
  72. J Biol Chem. 2013 Jun 14;288(24):17313-35 - PubMed
  73. FEBS Lett. 1998 Apr 10;426(1):17-20 - PubMed
  74. Autophagy. 2015;11(3):578-80 - PubMed
  75. Neuron. 2012 Feb 23;73(4):685-97 - PubMed
  76. Nature. 1963 Jan 12;197:192-3 - PubMed
  77. Cell Struct Funct. 2008;33(1):109-22 - PubMed

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