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Huang J, Peng J, Pearson JA, et al. Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cell Mol Immunol. 2021;18(2):328-338doi: 10.1038/s41423-020-00590-8.
Huang, J., Peng, J., Pearson, J. A., Efthimiou, G., Hu, Y., Tai, N., Xing, Y., Zhang, L., Gu, J., Jiang, J., Zhao, H., Zhou, Z., Wong, F. S., & Wen, L. (2021). Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular & molecular immunology, 18(2), 328-338. https://doi.org/10.1038/s41423-020-00590-8
Huang, Juan, et al. "Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function." Cellular & molecular immunology vol. 18,2 (2021): 328-338. doi: https://doi.org/10.1038/s41423-020-00590-8
Huang J, Peng J, Pearson JA, Efthimiou G, Hu Y, Tai N, Xing Y, Zhang L, Gu J, Jiang J, Zhao H, Zhou Z, Wong FS, Wen L. Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cell Mol Immunol. 2021 Feb;18(2):328-338. doi: 10.1038/s41423-020-00590-8. Epub 2021 Jan 11. PMID: 33432061; PMCID: PMC8027372.
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Cell Mol Immunol. 2021 Feb;18(2):328-338. doi: 10.1038/s41423-020-00590-8. Epub 2021 Jan 11.

Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function.

Cellular & molecular immunology

Juan Huang, Jian Peng, James Alexander Pearson, Georgios Efthimiou, Youjia Hu, Ningwen Tai, Yanpeng Xing, Luyao Zhang, Jianlei Gu, Jianping Jiang, Hongyu Zhao, Zhiguang Zhou, F Susan Wong, Li Wen

Affiliations

  1. National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  2. Section of Endocrinology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
  3. Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
  4. Department of Microbiology, University of Hull, Hull, UK.
  5. Department of Gastrointestinal Surgery of the First Hospital of Jilin University, Changchun, Jilin, China.
  6. Department of Biostatistics, Data Science & Genetics, Yale School of Public Health, New Haven, CT, USA.
  7. Section of Endocrinology, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA. [email protected].

PMID: 33432061 PMCID: PMC8027372 DOI: 10.1038/s41423-020-00590-8

Abstract

Innate immunity mediated by Toll-like receptors (TLRs), which can recognize pathogen molecular patterns, plays a critical role in type 1 diabetes development. TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and host tissue cells; however, its role in type 1 diabetes development remains unclear. In our study, we discovered that Tlr7-deficient (Tlr7

Keywords: B cell; Toll-like receptor 7; Type 1 diabetes

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