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Carniel BF, Marcon F, Rylance J, et al. Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine. JCI Insight. 2021;6(4)doi: 10.1172/jci.insight.141088.
Carniel, B. F., Marcon, F., Rylance, J., German, E. L., Zaidi, S., Reiné, J., Negera, E., Nikolaou, E., Pojar, S., Solórzano, C., Collins, A. M., Connor, V., Bogaert, D., Gordon, S. B., Nakaya, H. I., Ferreira, D. M., Jochems, S. P., & Mitsi, E. (2021). Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine. JCI insight, 6(4), . https://doi.org/10.1172/jci.insight.141088
Carniel, Beatriz F, et al. "Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine." JCI insight vol. 6,4 (2021). doi: https://doi.org/10.1172/jci.insight.141088
Carniel BF, Marcon F, Rylance J, German EL, Zaidi S, Reiné J, Negera E, Nikolaou E, Pojar S, Solórzano C, Collins AM, Connor V, Bogaert D, Gordon SB, Nakaya HI, Ferreira DM, Jochems SP, Mitsi E. Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine. JCI Insight. 2021 Feb 22;6(4). doi: 10.1172/jci.insight.141088. PMID: 33497364; PMCID: PMC7934923.
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JCI Insight. 2021 Feb 22;6(4). doi: 10.1172/jci.insight.141088.

Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine.

JCI insight

Beatriz F Carniel, Fernando Marcon, Jamie Rylance, Esther L German, Seher Zaidi, Jesus Reiné, Edessa Negera, Elissavet Nikolaou, Sherin Pojar, Carla Solórzano, Andrea M Collins, Victoria Connor, Debbie Bogaert, Stephen B Gordon, Helder I Nakaya, Daniela M Ferreira, Simon P Jochems, Elena Mitsi

Affiliations

  1. Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  2. Royal Liverpool and Broadgreen University Hospital, Liverpool, United Kingdom.
  3. Centre for Inflammation Research, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom.
  4. Department of Paediatric Immunology and Infectious Diseases, University Medical Centre Utrecht, Utrecht, Netherlands.
  5. Malawi-Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi.
  6. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paolo, Brazil.

PMID: 33497364 PMCID: PMC7934923 DOI: 10.1172/jci.insight.141088

Abstract

Influenza virus infections affect millions of people annually, and current available vaccines provide varying rates of protection. However, the way in which the nasal microbiota, particularly established pneumococcal colonization, shape the response to influenza vaccination is not yet fully understood. In this study, we inoculated healthy adults with live Streptococcus pneumoniae and vaccinated them 3 days later with either tetravalent-inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). Vaccine-induced immune responses were assessed in nose, blood, and lung. Nasal pneumococcal colonization had no impact upon TIV-induced antibody responses to influenza, which manifested in all compartments. However, experimentally induced pneumococcal colonization dampened LAIV-mediated mucosal antibody responses, primarily IgA in the nose and IgG in the lung. Pulmonary influenza-specific cellular responses were more apparent in the LAIV group compared with either the TIV or an unvaccinated group. These results indicate that TIV and LAIV elicit differential immunity to adults and that LAIV immunogenicity is diminished by the nasal presence of S. pneumoniae. Therefore, nasopharyngeal pneumococcal colonization may affect LAIV efficacy.

Keywords: Adaptive immunity; Immunology; Influenza; Vaccines

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