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Lin Y, Xue Y, Liu J, et al. Prognostic value of estimated plasma volume in patients with chronic systolic heart failure. J Investig Med. 2020;69(2):338-344doi: 10.1136/jim-2020-001538.
Lin, Y., Xue, Y., Liu, J., Wang, X., Wei, L., Bai, L., & Ma, A. (2021). Prognostic value of estimated plasma volume in patients with chronic systolic heart failure. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 69(2), 338-344. https://doi.org/10.1136/jim-2020-001538
Lin, Yuyao, et al. "Prognostic value of estimated plasma volume in patients with chronic systolic heart failure." Journal of investigative medicine : the official publication of the American Federation for Clinical Research vol. 69,2 (2021): 338-344. doi: https://doi.org/10.1136/jim-2020-001538
Lin Y, Xue Y, Liu J, Wang X, Wei L, Bai L, Ma A. Prognostic value of estimated plasma volume in patients with chronic systolic heart failure. J Investig Med. 2021 Feb;69(2):338-344. doi: 10.1136/jim-2020-001538. Epub 2020 Dec 22. PMID: 33443059; PMCID: PMC7848047.
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J Investig Med. 2021 Feb;69(2):338-344. doi: 10.1136/jim-2020-001538. Epub 2020 Dec 22.

Prognostic value of estimated plasma volume in patients with chronic systolic heart failure.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Yuyao Lin, Yanbo Xue, Jing Liu, Xiqiang Wang, Linyan Wei, Ling Bai, Aiqun Ma

Affiliations

  1. Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  2. Key Laboratory of Molecular Cardiology, Ministry of Education, Xi'an, Shaanxi, China.
  3. Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, People's Republic of China.
  4. Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China [email protected] [email protected].

PMID: 33443059 PMCID: PMC7848047 DOI: 10.1136/jim-2020-001538

Abstract

Assessing congestion is challenging but important to patients with chronic heart failure (CHF). However, there are limited data regarding the association between estimated plasma volume status (ePVS) determined using hemoglobin/hematocrit data and outcomes in patients with stable CHF. We prospectively analyzed 231 patients; the median follow-up period was 35.6 months. We calculated ePVS at admission using the Duarte and Strauss formula, derived from hemoglobin and hematocrit ratios and divided patients into three groups. The primary outcome was a composite of all-cause mortality or heart failure rehospitalization. Among 274 patients (61.98 years of age, 2.3% male), the mean ePVS was 3.98±0.90 dL/g. The third ePVS tertile had a higher proportion of primary outcome (71.4%) than the first or second tertile (48.1% and 59.7%, respectively; p=0.013). On multivariable Cox analysis, after adjusting for potential confounders, higher ePVS remained significantly associated with increased rate of primary outcome (adjusted HR 1.567, 95% CI 1.267 to 1.936; p<0.001). Kaplan-Meier survival analyses showed that the occurrence of primary outcome, all-cause mortality and rehospitalization increased progressively from first to third tertiles (p=0.006, 0.014 and 0.001; respectively). In receiver operating characteristic analysis, the area under the curve of ePVS for primary outcome was 0.645. ePVS determined using hemoglobin and hematocrit was independently associated with clinical outcomes for patients with stable CHF. Our study thus further strengthens the evidence that ePVS has important prognostic value in patients with stable CHF.

© American Federation for Medical Research 2021. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ.

Keywords: heart failure; prognosis

Conflict of interest statement

Competing interests: None declared.

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