Display options
Cite
Deng J, Cai X, Hao M, et al. Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes. Front Cardiovasc Med. 2021;8:637021doi: 10.3389/fcvm.2021.637021.
Deng, J., Cai, X., Hao, M., Liu, X., Chen, Z., Li, H., Liu, J., Liao, Y., Fu, H., Chen, H., Qin, G., & Yan, D. (2021). Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes. Frontiers in cardiovascular medicine, 8637021. https://doi.org/10.3389/fcvm.2021.637021
Deng, Jianxin, et al. "Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes." Frontiers in cardiovascular medicine vol. 8 (2021): 637021. doi: https://doi.org/10.3389/fcvm.2021.637021
Deng J, Cai X, Hao M, Liu X, Chen Z, Li H, Liu J, Liao Y, Fu H, Chen H, Qin G, Yan D. Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes. Front Cardiovasc Med. 2021 Feb 02;8:637021. doi: 10.3389/fcvm.2021.637021. eCollection 2021. PMID: 33604360; PMCID: PMC7884338.
Copy Download .nbib Format: NLM
Share it on

Front Cardiovasc Med. 2021 Feb 02;8:637021. doi: 10.3389/fcvm.2021.637021. eCollection 2021.

Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes.

Frontiers in cardiovascular medicine

Jianxin Deng, Xiangsheng Cai, Mingyu Hao, Xueting Liu, Zelong Chen, Haiyan Li, Junying Liu, Yunxiu Liao, Hao Fu, Huiyan Chen, Gangjian Qin, Dewen Yan

Affiliations

  1. Department of Endocrinology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center of Shenzhen University, Shenzhen, China.
  2. Center for Medical Experiments, University of Chinese Academy of Science-Shenzhen Hospital, Shenzhen, China.
  3. School of Basic Medical Science, Health Science Center of Shenzhen University, Shenzhen, China.
  4. Molecular Cardiology Program, Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States.

PMID: 33604360 PMCID: PMC7884338 DOI: 10.3389/fcvm.2021.637021

Abstract

Calcium dobesilate (CaD) is used effectively in patients with diabetic microvascular disorder, retinopathy, and nephropathy. Here we sought to determine whether it has an effect on cardiomyocytes calcium mishandling that is characteristic of diabetic cardiomyopathy. Cardiomyocytes were sterile isolated and cultured from 1 to 3 days neonatal rats and treated with vehicle (Control), 25 mM glucose+300 μM Palmitic acid (HG+PA), 100 μM CaD (CaD), or HG+PA+CaD to test the effects on calcium signaling (Ca

Copyright © 2021 Deng, Cai, Hao, Liu, Chen, Li, Liu, Liao, Fu, Chen, Qin and Yan.

Keywords: calcium dobesilate; calcium sparks; cardiomyocytes; hyperglycemia; laser scanning confocal microscope

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Circ Res. 2008 Dec 5;103(12):1466-72 - PubMed
  2. Med Sci Monit. 2006 Jul;12(7):RA130-47 - PubMed
  3. Diabetes. 2004 Dec;53(12):3201-8 - PubMed
  4. JAMA. 2011 Aug 24;306(8):856-63 - PubMed
  5. Circulation. 2010 Dec 21;122(25):2669-79 - PubMed
  6. Circ Heart Fail. 2020 Sep;13(9):e007054 - PubMed
  7. J Mol Cell Cardiol. 2014 Sep;74:260-73 - PubMed
  8. Diabetes. 2012 Nov;61(11):2958-66 - PubMed
  9. Nat Med. 2003 Jun;9(6):669-76 - PubMed
  10. Diabetes. 1999 Jan;48(1):198-202 - PubMed
  11. Cardiovasc Diabetol. 2011 Nov 04;10:97 - PubMed
  12. Shock. 2011 Apr;35(4):388-95 - PubMed
  13. Nature. 2002 Jan 10;415(6868):198-205 - PubMed
  14. J Diabetes Complications. 2017 Oct;31(10):1481-1490 - PubMed
  15. BMJ. 2020 Jul 15;370:m2297 - PubMed
  16. J Mol Cell Cardiol. 2002 Aug;34(8):951-69 - PubMed
  17. Cardiovasc Res. 2008 Jan 15;77(2):256-64 - PubMed
  18. Science. 1995 May 19;268(5213):1045-9 - PubMed
  19. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13258-63 - PubMed
  20. J Physiol. 2007 Dec 1;585(Pt 2):579-92 - PubMed
  21. Cardiology. 2014;129(2):75-83 - PubMed
  22. J Clin Invest. 2001 Oct;108(8):1167-74 - PubMed
  23. Am J Cardiol. 2000 Aug 1;86(3):309-12 - PubMed
  24. Exp Ther Med. 2018 Jan;15(1):719-722 - PubMed
  25. Free Radic Biol Med. 2008 Feb 1;44(3):375-85 - PubMed
  26. Am J Cardiol. 1972 Nov 8;30(6):595-602 - PubMed
  27. Neuroreport. 2000 Jul 14;11(10):2271-6 - PubMed
  28. Pharmacol Ther. 2014 Jun;142(3):375-415 - PubMed
  29. Free Radic Biol Med. 2013 Jul;60:292-9 - PubMed
  30. Front Biosci. 2002 Nov 01;7:d2072-80 - PubMed
  31. Nat Rev Endocrinol. 2011 Nov 08;8(4):228-36 - PubMed
  32. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16098-103 - PubMed
  33. Life Sci. 2019 Mar 15;221:348-353 - PubMed
  34. Am J Physiol Renal Physiol. 2003 Jun;284(6):F1263-73 - PubMed
  35. Circ Arrhythm Electrophysiol. 2011 Jun;4(3):362-72 - PubMed
  36. Biomed Res Int. 2017;2017:1909258 - PubMed
  37. J Mol Cell Cardiol. 2010 Sep;49(3):438-48 - PubMed

Publication Types