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Kim YJ, Kong Q, Yamamoto S, et al. An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system. Sci Adv. 2021;7(8)doi: 10.1126/sciadv.abc8310.
Kim, Y. J., Kong, Q., Yamamoto, S., Kuramoto, K., Huang, M., Wang, N., Hong, J. H., Xiao, T., Levine, B., Qiu, X., Zhao, Y., Miller, R. J., Dong, H., Meltzer, H. Y., Xu, M., & He, C. (2021). An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system. Science advances, 7(8), . https://doi.org/10.1126/sciadv.abc8310
Kim, Yoon-Jin, et al. "An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system." Science advances vol. 7,8 (2021). doi: https://doi.org/10.1126/sciadv.abc8310
Kim YJ, Kong Q, Yamamoto S, Kuramoto K, Huang M, Wang N, Hong JH, Xiao T, Levine B, Qiu X, Zhao Y, Miller RJ, Dong H, Meltzer HY, Xu M, He C. An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system. Sci Adv. 2021 Feb 19;7(8). doi: 10.1126/sciadv.abc8310. Print 2021 Feb. PMID: 33608268; PMCID: PMC7895433.
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Sci Adv. 2021 Feb 19;7(8). doi: 10.1126/sciadv.abc8310. Print 2021 Feb.

An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system.

Science advances

Yoon-Jin Kim, Qingyao Kong, Soh Yamamoto, Kenta Kuramoto, Mei Huang, Nan Wang, Jung Hwa Hong, Tong Xiao, Beth Levine, Xianxiu Qiu, Yanxiang Zhao, Richard J Miller, Hongxin Dong, Herbert Y Meltzer, Ming Xu, Congcong He

Affiliations

  1. Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  2. Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA.
  3. Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
  4. Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  5. Key Laboratory of Industrial Microbiology, Ministry of Education and Tianjin City, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
  6. Departments of Internal Medicine and Microbiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  7. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
  8. Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  9. Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. [email protected].

PMID: 33608268 PMCID: PMC7895433 DOI: 10.1126/sciadv.abc8310

Abstract

Drug abuse is a foremost public health problem. Cocaine is a widely abused drug worldwide that produces various reward-related behaviors. The mechanisms that underlie cocaine-induced disorders are unresolved, and effective treatments are lacking. Here, we found that an autophagy-related protein Becn2 is a previously unidentified regulator of cocaine reward behaviors.

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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