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Pawar S, Koneru T, McCord E, et al. LDL receptors and their role in targeted therapy for glioma: a review. Drug Discov Today. 2021;26(5):1212-1225doi: 10.1016/j.drudis.2021.02.008.
Pawar, S., Koneru, T., McCord, E., Tatiparti, K., Sau, S., & Iyer, A. K. (2021). LDL receptors and their role in targeted therapy for glioma: a review. Drug discovery today, 26(5), 1212-1225. https://doi.org/10.1016/j.drudis.2021.02.008
Pawar, Shreya, et al. "LDL receptors and their role in targeted therapy for glioma: a review." Drug discovery today vol. 26,5 (2021): 1212-1225. doi: https://doi.org/10.1016/j.drudis.2021.02.008
Pawar S, Koneru T, McCord E, Tatiparti K, Sau S, Iyer AK. LDL receptors and their role in targeted therapy for glioma: a review. Drug Discov Today. 2021 May;26(5):1212-1225. doi: 10.1016/j.drudis.2021.02.008. Epub 2021 Feb 18. PMID: 33609780.
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Drug Discov Today. 2021 May;26(5):1212-1225. doi: 10.1016/j.drudis.2021.02.008. Epub 2021 Feb 18.

LDL receptors and their role in targeted therapy for glioma: a review.

Drug discovery today

Shreya Pawar, Tejaswi Koneru, Eva McCord, Katyayani Tatiparti, Samaresh Sau, Arun K Iyer

Affiliations

  1. Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Troy High School, Troy, MI 48098, USA.
  2. Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Walled Lake Central High School, Commerce Charter Township, MI 48390, USA.
  3. Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Grosse Pointe South High School, Grosse Pointe Farms, MI 48236, USA.
  4. Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
  5. Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Molecular Imaging Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA. Electronic address: [email protected].

PMID: 33609780 DOI: 10.1016/j.drudis.2021.02.008

Abstract

Gliomas are highly lethal forms of cancers occurring in the brain. Delivering the drugs into the brain is a major challenge to the treatment of gliomas because of the highly selectively permeable blood-brain barrier (BBB). Tapping the potential of receptor-mediated drug delivery systems using targeted nanoparticles (NPs) is a sought-after step forward toward successful glioma treatment. Several receptors are the focus of research for application in drug delivery. Low-density lipoprotein receptors (LDLR) are abundantly expressed in both healthy brains and diseased brains with a disrupted BBB. In this review, we discuss the LDLR and the types of NPs that have been used to target the brain via this receptor.

Copyright © 2021 Elsevier Ltd. All rights reserved.

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