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Lee JS, Wang RX, Alexeev EE, et al. Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic. Gut Microbes. 2021;13(1):1-20doi: 10.1080/19490976.2021.1880241.
Lee, J. S., Wang, R. X., Alexeev, E. E., & Colgan, S. P. (2021). Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic. Gut microbes, 13(1), 1-20. https://doi.org/10.1080/19490976.2021.1880241
Lee, J Scott, et al. "Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic." Gut microbes vol. 13,1 (2021): 1-20. doi: https://doi.org/10.1080/19490976.2021.1880241
Lee JS, Wang RX, Alexeev EE, Colgan SP. Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic. Gut Microbes. 2021 Jan-Dec;13(1):1-20. doi: 10.1080/19490976.2021.1880241. PMID: 33583319; PMCID: PMC7889129.
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Gut Microbes. 2021 Jan-Dec;13(1):1-20. doi: 10.1080/19490976.2021.1880241.

Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic.

Gut microbes

J Scott Lee, Ruth X Wang, Erica E Alexeev, Sean P Colgan

Affiliations

  1. Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine , Aurora, United States.
  2. Department of Gastroenterology, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center , Los Angeles, United States.

PMID: 33583319 PMCID: PMC7889129 DOI: 10.1080/19490976.2021.1880241

Abstract

Inflammatory bowel disease (IBD) coincides with profound shifts in microbiota and host metabolic energy supply and demand. The gastrointestinal epithelium is anatomically positioned to provide a selective barrier between the anaerobic luminal microbiota and host lamina propria, with the microbiota and epithelium participating in an intricate energy exchange necessary for homeostasis. Maintenance and restoration of the barrier requires high energy flux and places significant demands on available substrates to generate ATP. It is recently appreciated that components of the microbiota contribute significantly to a multitude of biochemical pathways within and outside of the mucosa. Decades-old studies have appreciated that byproducts of the microbiota provide essential sources of energy to the intestinal epithelium, especially the colon. More recent work has unveiled the existence of numerous microbial-derived metabolites that support energy procurement within the mucosa. It is now appreciated that disease-associated shifts in the microbiota, termed dysbiosis, places significant demands on energy acquisition within the mucosa. Here, we review the topic of host- and microbial-derived components that influence tissue energetics in health and during disease.

Keywords: Metabolism; butyrate; colitis; creatine; epithelium; inflammation; microbiota; purine

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