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Zhang W, Zhang BL, He JJ, et al. Clinicopathological characteristics and treatment of young women with breast cancer in China: a nationwide multicenter 10-year retrospective study. Gland Surg. 2021;10(1):175-185doi: 10.21037/gs-20-574.
Zhang, W., Zhang, B. L., He, J. J., Fan, J. H., Li, J., Zhang, B., Yang, H. J., Xie, X. M., Tang, Z. H., Li, H., Li, J. Y., Wang, S. L., Qiao, Y. L., Huang, R., & Zhang, P. (2021). Clinicopathological characteristics and treatment of young women with breast cancer in China: a nationwide multicenter 10-year retrospective study. Gland surgery, 10(1), 175-185. https://doi.org/10.21037/gs-20-574
Zhang, Wei, et al. "Clinicopathological characteristics and treatment of young women with breast cancer in China: a nationwide multicenter 10-year retrospective study." Gland surgery vol. 10,1 (2021): 175-185. doi: https://doi.org/10.21037/gs-20-574
Zhang W, Zhang BL, He JJ, Fan JH, Li J, Zhang B, Yang HJ, Xie XM, Tang ZH, Li H, Li JY, Wang SL, Qiao YL, Huang R, Zhang P. Clinicopathological characteristics and treatment of young women with breast cancer in China: a nationwide multicenter 10-year retrospective study. Gland Surg. 2021 Jan;10(1):175-185. doi: 10.21037/gs-20-574. PMID: 33633974; PMCID: PMC7882316.
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Gland Surg. 2021 Jan;10(1):175-185. doi: 10.21037/gs-20-574.

Clinicopathological characteristics and treatment of young women with breast cancer in China: a nationwide multicenter 10-year retrospective study.

Gland surgery

Wei Zhang, Bai-Lin Zhang, Jian-Jun He, Jin-Hu Fan, Jing Li, Bin Zhang, Hong-Jian Yang, Xiao-Ming Xie, Zhong-Hua Tang, Hui Li, Jia-Yuan Li, Shu-Lian Wang, You-Lin Qiao, Rong Huang, Pin Zhang

Affiliations

  1. Department of Breast Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  2. Department of Breast Cancer, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union of Medical College, Beijing, China.
  3. Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  4. Department of Occupational and Environmental Health, West China School of Public Health, Sichuan University, Chengdu, China.
  5. Department of Breast Surgery, Liaoning Cancer Hospital, Shenyang, China.
  6. Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
  7. Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.
  8. Department of Breast-thyroid Surgery, Xiangya Second Hospital, Central South University, Changsha, China.
  9. Department of Breast Surgery, the Second People's Hospital of Sichuan Province, Chengdu, China.
  10. Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, China.
  11. Department of Radiotherapy, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
  12. Department of Medical Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

PMID: 33633974 PMCID: PMC7882316 DOI: 10.21037/gs-20-574

Abstract

BACKGROUND: Breast cancer is currently the most common female malignancy in China. However, the clinical features and overall prognosis of young women diagnosed with this malignancy remain unclear. This study aimed to describe the clinicopathological characteristics of young patients (≤34 years of age) with breast cancer and explore the current treatment approaches used in China.

METHODS: This was a hospital-based, multicenter, retrospective study of women with breast cancer across seven Chinese hospitals from 1999 to 2008. A total of 295 young (≤34 years of age) patients (research group) and 2,119 women aged 35 to 49 years (control group) were included in the study. Patient epidemiology, pre-operative examinations, clinical pathology, and treatment were analyzed.

RESULTS: The percentage of young patients with breast cancer in the study group was 7.01%. These young women had a lower body mass index (BMI), a higher level of education, a lower number of previous births, and a lower history of breastfeeding than the control group (P<0.05). Increasingly, pre-operative use of ultrasound and magnetic resonance imaging are being used to diagnose breast cancer in young women in China. In young women with breast cancer, breast cancer not otherwise specified (NOS) was the primary pathology. The carcinoma in young women was more prone to lymph node metastasis, showed less progesterone receptor (PR) expression, and was more advanced than observed in the control group (P<0.05). We found that the number of young breast cancer patients undergoing breast-conserving surgery in China is increasing.

CONCLUSIONS: Young breast cancer patients display unique clinicopathological features, including tumors of a higher grade than those aged 35 years or older. As breast cancer is more aggressive in younger women, prevention and early diagnosis are critical, and new policies should be developed in line with these findings.

2021 Gland Surgery. All rights reserved.

Keywords: Young age; breast cancer; clinicopathological characteristics; retrospective study

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/gs-20-574). The authors have no conflicts of interest to declare.

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