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Barik A, Sathyamurthy A, Thompson J, et al. A spinoparabrachial circuit defined by Tacr1 expression drives pain. Elife. 2021;10doi: 10.7554/eLife.61135.
Barik, A., Sathyamurthy, A., Thompson, J., Seltzer, M., Levine, A., & Chesler, A. (2021). A spinoparabrachial circuit defined by Tacr1 expression drives pain. eLife, 10. https://doi.org/10.7554/eLife.61135
Barik, Arnab, et al. "A spinoparabrachial circuit defined by Tacr1 expression drives pain." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.61135
Barik A, Sathyamurthy A, Thompson J, Seltzer M, Levine A, Chesler A. A spinoparabrachial circuit defined by Tacr1 expression drives pain. Elife. 2021 Feb 16;10. doi: 10.7554/eLife.61135. PMID: 33591273; PMCID: PMC7993995.
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Elife. 2021 Feb 16;10. doi: 10.7554/eLife.61135.

A spinoparabrachial circuit defined by Tacr1 expression drives pain.

eLife

Arnab Barik, Anupama Sathyamurthy, James Thompson, Mathew Seltzer, Ariel Levine, Alexander Chesler

Affiliations

  1. National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, United States.
  2. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.

PMID: 33591273 PMCID: PMC7993995 DOI: 10.7554/eLife.61135

Abstract

Painful stimuli evoke a mixture of sensations, negative emotions and behaviors. These myriad effects are thought to be produced by parallel ascending circuits working in combination. Here, we describe a pathway from spinal cord to brain for ongoing pain. Activation of a subset of spinal neurons expressing Tacr1 evokes a full repertoire of somatotopically directed pain-related behaviors in the absence of noxious input. Tacr1 projection neurons (expressing NKR1) target a tiny cluster of neurons in the superior lateral parabrachial nucleus (PBN-SL). We show that these neurons, which also express Tacr1 (PBN-SL

Keywords: brainstem; mouse; neuroscience; pain; parabrachial nucleus; somatosensation; spinal cord

Conflict of interest statement

AB, AS, JT, MS, AL, AC No competing interests declared

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