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Xu CL, Nao JZ, Shen YJ, et al. Long-term music adjuvant therapy enhances the efficacy of sub-dose antiepileptic drugs in temporal lobe epilepsy. CNS Neurosci Ther. 2021;doi: 10.1111/cns.13623.
Xu, C. L., Nao, J. Z., Shen, Y. J., Gong, Y. W., Tan, B., Zhang, S., Shen, K. X., Sun, C. R., Wang, Y., & Chen, Z. (2021). Long-term music adjuvant therapy enhances the efficacy of sub-dose antiepileptic drugs in temporal lobe epilepsy. CNS neuroscience & therapeutics, . https://doi.org/10.1111/cns.13623
Xu, Ceng-Lin, et al. "Long-term music adjuvant therapy enhances the efficacy of sub-dose antiepileptic drugs in temporal lobe epilepsy." CNS neuroscience & therapeutics vol. (2021). doi: https://doi.org/10.1111/cns.13623
Xu CL, Nao JZ, Shen YJ, Gong YW, Tan B, Zhang S, Shen KX, Sun CR, Wang Y, Chen Z. Long-term music adjuvant therapy enhances the efficacy of sub-dose antiepileptic drugs in temporal lobe epilepsy. CNS Neurosci Ther. 2021 Feb 28; doi: 10.1111/cns.13623. Epub 2021 Feb 28. PMID: 33644976.
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CNS Neurosci Ther. 2021 Feb 28; doi: 10.1111/cns.13623. Epub 2021 Feb 28.

Long-term music adjuvant therapy enhances the efficacy of sub-dose antiepileptic drugs in temporal lobe epilepsy.

CNS neuroscience & therapeutics

Ceng-Lin Xu, Jia-Zhen Nao, Yu-Jia Shen, Yi-Wei Gong, Bei Tan, Shuo Zhang, Ke-Xin Shen, Cui-Rong Sun, Yi Wang, Zhong Chen

Affiliations

  1. Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  2. Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, China.
  3. Institute of Drug Metabolism and Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

PMID: 33644976 DOI: 10.1111/cns.13623

Abstract

AIMS: Noninvasive music adjuvant therapy shows great potential in improving seizure control when combined with routine antiepileptic drugs. However, the diversity of previous music protocols has resulted in disparate outcomes. The optimized protocol and features for music adjuvant therapy are still not fully understood which limits its feasibility.

METHODS: By applying different regimens of music therapy in various temporal lobe epilepsy models, we evaluated the effect of music in combination with sub-dose drugs on epileptic seizures to determine the optimized protocol.

RESULTS: A subgroup of kindled mice that were responsive to music adjuvant therapy was screened. In those mice, sub-dose drugs which were noneffective on kindled seizures, alleviated seizure severity after 12 h/day Mozart K.448 for 14 days. Shorter durations of music therapy (2 and 6 h/day) were ineffective. Furthermore, only full-length Mozart K.448, not its episodes or other music varieties, was capable of enhancing the efficacy of sub-dose drugs. This music therapeutic effect was not due to increasing cerebral drug concentration, but instead was related with the modulation of seizure electroencephalogram (EEG) spectral powers in the hippocampus.

CONCLUSION: These results indicate that long-term full-length Mozart K.448 could enhance the anti-seizure efficacy of sub-dose drugs and may be a promising noninvasive adjuvant therapy for temporal lobe epilepsy.

© 2021 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.

Keywords: Mozart K.448; music adjunctive therapy; sub-dose antiepileptic drugs; temporal lobe epilepsy

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