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Holland N, Robbins TW, Rowe JB. The role of noradrenaline in cognition and cognitive disorders. Brain. 2021;144(8):2243-2256doi: 10.1093/brain/awab111.
Holland, N., Robbins, T. W., & Rowe, J. B. (2021). The role of noradrenaline in cognition and cognitive disorders. Brain : a journal of neurology, 144(8), 2243-2256. https://doi.org/10.1093/brain/awab111
Holland, Negin, et al. "The role of noradrenaline in cognition and cognitive disorders." Brain : a journal of neurology vol. 144,8 (2021): 2243-2256. doi: https://doi.org/10.1093/brain/awab111
Holland N, Robbins TW, Rowe JB. The role of noradrenaline in cognition and cognitive disorders. Brain. 2021 Sep 04;144(8):2243-2256. doi: 10.1093/brain/awab111. PMID: 33725122; PMCID: PMC8418349.
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Brain. 2021 Sep 04;144(8):2243-2256. doi: 10.1093/brain/awab111.

The role of noradrenaline in cognition and cognitive disorders.

Brain : a journal of neurology

Negin Holland, Trevor W Robbins, James B Rowe

Affiliations

  1. Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0SZ, UK.
  2. Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.
  3. Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
  4. MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 7EF, UK.

PMID: 33725122 PMCID: PMC8418349 DOI: 10.1093/brain/awab111

Abstract

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the forebrain originating from the locus coeruleus, acting through alpha and beta adrenoreceptors. Loss of these projections is common in neurodegenerative diseases and contributes to their cognitive and behavioural deficits. We review the evidence for a noradrenergic modulation of cognition in its contribution to Alzheimer's disease, Parkinson's disease and other cognitive disorders. We discuss the advances in human imaging and computational methods that quantify the locus coeruleus and its function in humans, and highlight the potential for new noradrenergic treatment strategies.

© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

Keywords: cognition; dementia; locus coeruleus; neurodegeneration; noradrenaline

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