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Di Renzo M, di Castelbianco FB, Alberto V, et al. Prognostic factors and predictors of outcome in children with autism spectrum disorder: the role of the paediatrician. Ital J Pediatr. 2021;47(1):67doi: 10.1186/s13052-021-01008-5.
Di Renzo, M., di Castelbianco, F. B., Alberto, V., Antonio, D. V., Giovanni, C., Vanadia, E., Petrillo, M., Davide, T., Racinaro, L., & Rea, M. (2021). Prognostic factors and predictors of outcome in children with autism spectrum disorder: the role of the paediatrician. Italian journal of pediatrics, 47(1), 67. https://doi.org/10.1186/s13052-021-01008-5
Di Renzo, Magda, et al. "Prognostic factors and predictors of outcome in children with autism spectrum disorder: the role of the paediatrician." Italian journal of pediatrics vol. 47,1 (2021): 67. doi: https://doi.org/10.1186/s13052-021-01008-5
Di Renzo M, di Castelbianco FB, Alberto V, Antonio DV, Giovanni C, Vanadia E, Petrillo M, Davide T, Racinaro L, Rea M. Prognostic factors and predictors of outcome in children with autism spectrum disorder: the role of the paediatrician. Ital J Pediatr. 2021 Mar 18;47(1):67. doi: 10.1186/s13052-021-01008-5. PMID: 33736673; PMCID: PMC7977604.
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Ital J Pediatr. 2021 Mar 18;47(1):67. doi: 10.1186/s13052-021-01008-5.

Prognostic factors and predictors of outcome in children with autism spectrum disorder: the role of the paediatrician.

Italian journal of pediatrics

Magda Di Renzo, Federico Bianchi di Castelbianco, Villani Alberto, Del Vecchio Antonio, Corsello Giovanni, Elena Vanadia, Massimiliano Petrillo, Trapolino Davide, Lidia Racinaro, Monica Rea

Affiliations

  1. Institute of Ortofonologia (IdO), Via Salaria 30, 00198, Rome, Italy. [email protected].
  2. Institute of Ortofonologia (IdO), Via Tagliamento 25, 00198, Rome, Italy.
  3. Società Italiana di Pediatria, Rome, Italy.
  4. Dipartimento Emergenza Accettazione Pediatria Generale, IRCCS - Ospedale Pediatrico Bambino Gesù, Rome, Italy.
  5. Terapia Intensiva Neonatale e Neonatologia, Ospedale Di Venere, Bari, Italy.
  6. Clinica Pediatrica Università di Palermo, Palermo, Italy.

PMID: 33736673 PMCID: PMC7977604 DOI: 10.1186/s13052-021-01008-5

Abstract

BACKGROUND: Autism spectrum disorder is a complex condition with wide variation in type and severity that involves persistent challenges in social interaction, speech and nonverbal communication, restricted/repetitive behaviours and adaptive behaviours. In recent years, research has deepened the study of the predictive factors of optimal outcome, intended as indicators of positive trajectory in children with a previous diagnosis of autism who, after a therapeutic path, show a significant reduction in the "core" symptoms of autism and a positive evolution in social, adaptive, affective, and relational skills.

METHODS: The study included 40 children aged 21 to 66 months, enrolled between 2015 and 2016 for an autism spectrum disorder clinical suspicious. Children were re-evaluated after at least 2 years of therapy and they were divided into two groups: the ASD-ASD group included children with a confirmed diagnosis of ASD, and the ASD-OO comparison group included children who no longer met the criteria for an autism classification. The aim of this retrospective study was to investigate the presence of cognitive, emotional and relational predictors capable of predicting the presence of optimal outcome in with a diagnosis of autism; the predictors taken into consideration were the intelligence quotient, the play, the emotional contagion and the understanding of other's intentions. In this way, it is possible to support clinicians in defining a more complete diagnostic framework of autism, using assessment tools that can be administered quickly and therefore suitable for short observation sessions in paediatric patients.

RESULTS: The findings showed that 15 out of 40 children, after at least for 2 years, no longer fell into the diagnostic ASD category based on the ADOS-2, DSM-5 and clinical criteria. The children in the ASD-OO group initially had a higher IQ than those in the ASD-ASD group, lower severity of autistic symptoms, greater understanding of intentions, more emotional contagion, and better quality of play. The results suggest that the initial coexistence of skills in these areas at the time of the first diagnostic assessment may allow us to predict the possibility of achieving optimal outcome after 2 years of therapy.

CONCLUSIONS: The data of this study highlight the importance of considering, during assessment, intelligence quotient, play, emotional contagion, and understanding of the intentions of others as potential prognostic predictors that can become useful tools for clinicians and paediatricians. This allows us to focus attention, in both the diagnostic and prognostic phases, on emotional-relational variables that can support the clinician in defining a more complete diagnostic framework and in planning a more personalized therapeutic path.

Keywords: Autism spectrum disorder; Emotional variables; Outcome; Paediatrician; Predictors

References

  1. J Consult Clin Psychol. 1987 Feb;55(1):3-9 - PubMed
  2. J Autism Dev Disord. 2018 May;48(5):1436-1445 - PubMed
  3. J Autism Dev Disord. 2017 Apr;47(4):1166-1182 - PubMed
  4. J Child Psychol Psychiatry. 2007 Aug;48(8):793-802 - PubMed
  5. J Autism Dev Disord. 2012 Apr;42(4):512-20 - PubMed
  6. J Autism Dev Disord. 2015 Jul;45(7):2035-45 - PubMed
  7. J Autism Dev Disord. 2007 Jan;37(1):98-107 - PubMed
  8. Eur Child Adolesc Psychiatry. 2005 Mar;14(2):65-72 - PubMed
  9. J Autism Dev Disord. 2008 May;38(5):827-39 - PubMed
  10. J Child Adolesc Ment Health. 2013;25(2):177-8 - PubMed
  11. J Child Psychol Psychiatry. 2005 May;46(5):500-13 - PubMed
  12. Transl Psychiatry. 2014 Jan 14;4:e343 - PubMed
  13. MMWR Surveill Summ. 2016 Apr 01;65(3):1-23 - PubMed
  14. J Autism Dev Disord. 2007 Jul;37(6):1024-39 - PubMed
  15. J Autism Dev Disord. 2016 Jan;46(1):1-9 - PubMed
  16. Dev Psychol. 1995 Sep;31(5):838-850 - PubMed
  17. MMWR Surveill Summ. 2014 Mar 28;63(2):1-21 - PubMed
  18. Dev Sci. 2010 Mar;13(2):307-19 - PubMed
  19. J Autism Dev Disord. 2006 Aug;36(6):807-28 - PubMed
  20. J Autism Dev Disord. 2001 Dec;31(6):589-99 - PubMed
  21. Autism Res. 2012 Jun;5(3):160-79 - PubMed
  22. J Child Psychol Psychiatry. 2013 Feb;54(2):195-205 - PubMed
  23. J Child Psychol Psychiatry. 2015 Sep;56(9):988-98 - PubMed
  24. Ann Ist Super Sanita. 2011;47(4):341-8 - PubMed
  25. Pediatrics. 2011 May;127(5):e1303-11 - PubMed
  26. J Child Psychol Psychiatry. 2013 Feb;54(2):178-85 - PubMed
  27. Neuropsychol Rev. 2008 Dec;18(4):339-66 - PubMed
  28. J Clin Child Adolesc Psychol. 2008 Jan;37(1):8-38 - PubMed
  29. Dev Psychopathol. 2020 Feb;32(1):383-393 - PubMed
  30. Am J Intellect Dev Disabil. 2009 Jan;114(1):23-41 - PubMed

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