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Fan L, Zhu X, Zheng Y, et al. Magnesium Treatment on Methylation Changes of Transmembrane Serine Protease 2 (TMPRSS2). medRxiv. 2021;doi: 10.1101/2021.03.11.21253287.
Fan, L., Zhu, X., Zheng, Y., Zhang, W., Seidner, D. L., Ness, R., Murff, H. J., Yu, C., Huang, X., Shrubsole, M. J., Hou, L., & Dai, Q. (2021). Magnesium Treatment on Methylation Changes of Transmembrane Serine Protease 2 (TMPRSS2). medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2021.03.11.21253287
Fan, Lei, et al. "Magnesium Treatment on Methylation Changes of Transmembrane Serine Protease 2 (TMPRSS2)." medRxiv : the preprint server for health sciences vol. (2021). doi: https://doi.org/10.1101/2021.03.11.21253287
Fan L, Zhu X, Zheng Y, Zhang W, Seidner DL, Ness R, Murff HJ, Yu C, Huang X, Shrubsole MJ, Hou L, Dai Q. Magnesium Treatment on Methylation Changes of Transmembrane Serine Protease 2 (TMPRSS2). medRxiv. 2021 Mar 12; doi: 10.1101/2021.03.11.21253287. PMID: 33758885; PMCID: PMC7987044.
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medRxiv. 2021 Mar 12; doi: 10.1101/2021.03.11.21253287.

Magnesium Treatment on Methylation Changes of Transmembrane Serine Protease 2 (TMPRSS2).

medRxiv : the preprint server for health sciences

Lei Fan, Xiangzhu Zhu, Yinan Zheng, Wei Zhang, Douglas L Seidner, Reid Ness, Harvey J Murff, Chang Yu, Xiang Huang, Martha J Shrubsole, Lifang Hou, Qi Dai

PMID: 33758885 PMCID: PMC7987044 DOI: 10.1101/2021.03.11.21253287

Abstract

BACKGROUND: The viral entry of SARS-CoV-2 requires host-expressed TMPRSS2 to facilitate the viral spike (S) protein priming.

OBJECTIVES: To test the hypothesis that Mg treatment leads to DNA methylation changes in

METHODS: This study is nested within the Personalized Prevention of Colorectal Cancer Trial (PPCCT), a double-blind 2×2 factorial randomized controlled trial, which enrolled 250 participants from Vanderbilt University Medical Center. Target doses for both Mg and placebo arms were personalized.

RESULTS: We found that 12-week of personalized Mg treatment significantly increased 5-mC methylation at cg16371860 (TSS1500, promoter) by 7.2% compared to placebo arm (decreased by 0.1%) in those aged < 65 years old. The difference remained statistically significant after adjusting for age, sex and baseline methylation as well as FDR correction (FDR-adjusted

CONCLUSION: Among individuals aged younger than 65 years with the Ca:Mg intake ratios equal to or over 2.6, reducing Ca:Mg ratios to around 2.3 increased 5-mC modifications (i.e. cg16371860) and reduced 5-hmC modifications (i.e. cg26337277) in the

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