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Liu Z, Meng T, Tang X, et al. The Promise of Aggregation-Induced Emission Luminogens for Detecting COVID-19. Front Immunol. 2021;12:635558doi: 10.3389/fimmu.2021.635558.
Liu, Z., Meng, T., Tang, X., Tian, R., & Guan, W. (2021). The Promise of Aggregation-Induced Emission Luminogens for Detecting COVID-19. Frontiers in immunology, 12635558. https://doi.org/10.3389/fimmu.2021.635558
Liu, Zongwei, et al. "The Promise of Aggregation-Induced Emission Luminogens for Detecting COVID-19." Frontiers in immunology vol. 12 (2021): 635558. doi: https://doi.org/10.3389/fimmu.2021.635558
Liu Z, Meng T, Tang X, Tian R, Guan W. The Promise of Aggregation-Induced Emission Luminogens for Detecting COVID-19. Front Immunol. 2021 Feb 16;12:635558. doi: 10.3389/fimmu.2021.635558. eCollection 2021. PMID: 33679789; PMCID: PMC7928409.
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Front Immunol. 2021 Feb 16;12:635558. doi: 10.3389/fimmu.2021.635558. eCollection 2021.

The Promise of Aggregation-Induced Emission Luminogens for Detecting COVID-19.

Frontiers in immunology

Zongwei Liu, Ting Meng, Xiaofang Tang, Ran Tian, Weijiang Guan

Affiliations

  1. Department of Respiratory Medicine, Lianyungang Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Lianyungang, China.
  2. The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
  3. State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, China.
  4. Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

PMID: 33679789 PMCID: PMC7928409 DOI: 10.3389/fimmu.2021.635558

Abstract

The long-term pandemic of coronavirus disease 2019 (COVID-19) requires sensitive and accurate diagnostic assays to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and SARS-CoV-2 antibodies in infected individuals. Currently, RNA of SARS-CoV-2 virus is mainly detected by reverse transcription-polymerase chain reaction (RT-PCR)-based nucleic acid assays, while SARS-CoV-2 antigen and antibody are identified by immunological assays. Both nucleic acid assays and immunological assays rely on the luminescence signals of specific luminescence probes for qualitative and quantitative detection. The exploration of novel luminescence probes will play a crucial role in improving the detection sensitivity of the assays. As innate probes, aggregation-induced emission (AIE) luminogens (AIEgens) exhibit negligible luminescence in the free state but enhanced luminescence in the aggregated or restricted states. Moreover, AIEgen-based nanoparticles (AIE dots) offer efficient luminescence, good biocompatibility and water solubility, and superior photostability. Both AIEgens and AIE dots have been widely used for high-performance detection of biomolecules and small molecules, chemical/biological imaging, and medical therapeutics. In this review, the availability of AIEgens and AIE dots in nucleic acid assays and immunological assays are enumerated and discussed. By building a bridge between AIE materials and COVID-19, we hope to inspire researchers to use AIE materials as a powerful weapon against COVID-19.

Copyright © 2021 Liu, Meng, Tang, Tian and Guan.

Keywords: COVID-19; aggregation-induced emission; diagnosis; immunoassay; nucleic acid

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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