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Zhang C, Wu Y, Xu X, et al. [Current status and future perspectives of metabolic network models of industrial microorganisms]. Sheng Wu Gong Cheng Xue Bao. 2021;37(3):860-873doi: 10.13345/j.cjb.200640.
Zhang, C., Wu, Y., Xu, X., Lv, X., Li, J., Du, G., & Liu, L. (2021). [Current status and future perspectives of metabolic network models of industrial microorganisms]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 37(3), 860-873. https://doi.org/10.13345/j.cjb.200640
Zhang, Chenyang, et al. "[Current status and future perspectives of metabolic network models of industrial microorganisms]." Sheng wu gong cheng xue bao = Chinese journal of biotechnology vol. 37,3 (2021): 860-873. doi: https://doi.org/10.13345/j.cjb.200640
Zhang C, Wu Y, Xu X, Lv X, Li J, Du G, Liu L. [Current status and future perspectives of metabolic network models of industrial microorganisms]. Sheng Wu Gong Cheng Xue Bao. 2021 Mar 25;37(3):860-873. doi: 10.13345/j.cjb.200640. Chinese. PMID: 33783155.
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Sheng Wu Gong Cheng Xue Bao. 2021 Mar 25;37(3):860-873. doi: 10.13345/j.cjb.200640.

[Current status and future perspectives of metabolic network models of industrial microorganisms].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Article in Chinese]
Chenyang Zhang, Yaokang Wu, Xianhao Xu, Xueqin Lv, Jianghua Li, Guocheng Du, Long Liu

Affiliations

  1. Science Center for Future Foods, Jiangnan University, Wuxi 214122, Jiangsu, China.
  2. Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China.

PMID: 33783155 DOI: 10.13345/j.cjb.200640

Abstract

Genome-scale metabolic network model (GSMM) is an extremely important guiding tool in the targeted modification of industrial microbial strains, which helps researchers to quickly obtain industrial microbes with specific traits and has attracted increasing attention. Here we reviewe the development history of GSMM and summarized the construction method of GSMM. Furthermore, the development and application of GSMM in industrial microorganisms are elaborated by using four typical industrial microorganisms (Bacillus subtilis, Escherichia coli, Corynebacterium glutamicum, and Saccharomyces cerevisiae) as examples. In addition, prospects in the development trend of GSMM are proposed.

Keywords: genome-scale metabolic network model; model application; model construction; model evaluate indicators; typical industrial microorganisms

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