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Gao WJ, Liu JX, Liu MN, et al. Macrophage 3D migration: A potential therapeutic target for inflammation and deleterious progression in diseases. Pharmacol Res. 2021;167:105563doi: 10.1016/j.phrs.2021.105563.
Gao, W. J., Liu, J. X., Liu, M. N., Yao, Y. D., Liu, Z. Q., Liu, L., He, H. H., & Zhou, H. (2021). Macrophage 3D migration: A potential therapeutic target for inflammation and deleterious progression in diseases. Pharmacological research, 167105563. https://doi.org/10.1016/j.phrs.2021.105563
Gao, Wan-Jiao, et al. "Macrophage 3D migration: A potential therapeutic target for inflammation and deleterious progression in diseases." Pharmacological research vol. 167 (2021): 105563. doi: https://doi.org/10.1016/j.phrs.2021.105563
Gao WJ, Liu JX, Liu MN, Yao YD, Liu ZQ, Liu L, He HH, Zhou H. Macrophage 3D migration: A potential therapeutic target for inflammation and deleterious progression in diseases. Pharmacol Res. 2021 May;167:105563. doi: 10.1016/j.phrs.2021.105563. Epub 2021 Mar 19. PMID: 33746053.
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Pharmacol Res. 2021 May;167:105563. doi: 10.1016/j.phrs.2021.105563. Epub 2021 Mar 19.

Macrophage 3D migration: A potential therapeutic target for inflammation and deleterious progression in diseases.

Pharmacological research

Wan-Jiao Gao, Jian-Xin Liu, Meng-Nan Liu, Yun-Da Yao, Zhong-Qiu Liu, Liang Liu, Huan-Huan He, Hua Zhou

Affiliations

  1. Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, PR China.
  2. School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua City, Hunan Province, PR China.
  3. Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, PR China; National Traditional Chinese Medicine Clinical Research Base and Department of Cardiovascular Medicine, Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, Sichuan, PR China.
  4. Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou, PR China.
  5. Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, PR China; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou, PR China.
  6. The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai City, Guangdong Province 519000, PR China.
  7. Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, PR China; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou, PR China; Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai City, Guangdong Province 519000, PR China. Electronic address: [email protected].

PMID: 33746053 DOI: 10.1016/j.phrs.2021.105563

Abstract

Macrophages are heterogeneous cells that have different physiological functions, such as chemotaxis, phagocytosis, endocytosis, and secretion of various factors. All physiological functions of macrophages are integral to homeostasis, immune defense and tissue repair. However, in several diseases, macrophages are recruited from the blood towards inflammatory sites. This process is called macrophage migration, which promotes deleterious disease progression. Macrophage migration is a key player in many inflammatory diseases, autoimmune diseases and cancers because it contributes to the accumulation of proinflammatory factors, the destruction of tissues and the development of tumors. Therefore, macrophage migration is proposed to be a potential therapeutic target. Macrophages migrate between two-dimensional (2D) and three-dimensional (3D) environments, implying that distinct migratory features and mechanisms are involved. Compared with the 2D migration of macrophages, 3D migration involves more complex variations in cellular morphology and dynamics. The structure of the extracellular matrix, a key factor, is modified in diseases that influence macrophage 3D migration. Macrophage 3D migration relates to disease pathology. Research that focuses on macrophage 3D migration is an emerging field and was reviewed in this article to indicate the molecular and cellular mechanisms of macrophage migration in 3D environments and to provide potential targets for controlling disease progression associated with this migration.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Autoimmune disease; Cancer; Extracellular matrix; Inflammation; Macrophage; Macrophage migration

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