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Ishihara K, Fukazawa K, Sharma V, et al. Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface. ACS Omega. 2021;6(10):7058-7067doi: 10.1021/acsomega.0c06327.
Ishihara, K., Fukazawa, K., Sharma, V., Liang, S., Shows, A., Dunbar, D. C., Zheng, Y., Ge, J., Zhang, S., Hong, Y., Shi, X., & Wu, J. Y. (2021). Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface. ACS omega, 6(10), 7058-7067. https://doi.org/10.1021/acsomega.0c06327
Ishihara, Kazuhiko, et al. "Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface." ACS omega vol. 6,10 (2021): 7058-7067. doi: https://doi.org/10.1021/acsomega.0c06327
Ishihara K, Fukazawa K, Sharma V, Liang S, Shows A, Dunbar DC, Zheng Y, Ge J, Zhang S, Hong Y, Shi X, Wu JY. Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface. ACS Omega. 2021 Feb 26;6(10):7058-7067. doi: 10.1021/acsomega.0c06327. eCollection 2021 Mar 16. PMID: 33748619; PMCID: PMC7970573.
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ACS Omega. 2021 Feb 26;6(10):7058-7067. doi: 10.1021/acsomega.0c06327. eCollection 2021 Mar 16.

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface.

ACS omega

Kazuhiko Ishihara, Kyoko Fukazawa, Vinay Sharma, Shuang Liang, Amanda Shows, Daniel Chuck Dunbar, Yang Zheng, Junhao Ge, Steve Zhang, Ye Hong, Xinfeng Shi, James Yuliang Wu

Affiliations

  1. Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  2. Alcon Vision LLC, Fort Worth, Texas 76134, United States.
  3. Alcon Vision LLC, Duluth, Georgia 30097, United States.

PMID: 33748619 PMCID: PMC7970573 DOI: 10.1021/acsomega.0c06327

Abstract

Inspired by the cell membrane surface as well as the ocular tissue, a novel and clinically applicable antifouling silicone hydrogel contact lens material was developed. The unique chemical and biological features on the surface on a silicone hydrogel base substrate were achieved by a cross-linked polymer layer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), which was considered important for optimal on-eye performance. The effects of the polymer layer on adsorption of biomolecules, such as lipid and proteins, and adhesion of cells and bacteria were evaluated and compared with several conventional silicone hydrogel contact lens materials. The MPC polymer layer provided significant resistance to lipid deposition as visually demonstrated by the three-dimensional confocal images of whole contact lenses. Also, fibroblast cell adhesion was decreased to a 1% level compared with that on the conventional silicone hydrogel contact lenses. The movement of the cells on the surface of the MPC polymer-modified lens material was greater compared with other silicone hydrogel contact lenses indicating that lubrication of the contact lenses on ocular tissue might be improved. The superior hydrophilic nature of the MPC polymer layer provides improved surface properties compared to the underlying silicone hydrogel base substrate.

© 2021 American Chemical Society.

Conflict of interest statement

The authors declare the following competing financial interest(s): V.S., S.L., A.S, D.C.D., Y.Z., J.G., S.Z., Y.H., X.S., and J.Y.W. are employees of Alcon Vision, LLC, Fort Worth, TX, and Duluth, GA,

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