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Zabetian-Targhi F, Srikanth VK, Beare R, et al. The Association Between Physical Activity Intensity, Cognition, and Brain Structure in People With Type 2 Diabetes. J Gerontol A Biol Sci Med Sci. 2021;76(11):2047-2053doi: 10.1093/gerona/glab067.
Zabetian-Targhi, F., Srikanth, V. K., Beare, R., Breslin, M., Moran, C., Wang, W., Wu, F., Smith, K. J., & Callisaya, M. L. (2021). The Association Between Physical Activity Intensity, Cognition, and Brain Structure in People With Type 2 Diabetes. The journals of gerontology. Series A, Biological sciences and medical sciences, 76(11), 2047-2053. https://doi.org/10.1093/gerona/glab067
Zabetian-Targhi, Fateme, et al. "The Association Between Physical Activity Intensity, Cognition, and Brain Structure in People With Type 2 Diabetes." The journals of gerontology. Series A, Biological sciences and medical sciences vol. 76,11 (2021): 2047-2053. doi: https://doi.org/10.1093/gerona/glab067
Zabetian-Targhi F, Srikanth VK, Beare R, Breslin M, Moran C, Wang W, Wu F, Smith KJ, Callisaya ML. The Association Between Physical Activity Intensity, Cognition, and Brain Structure in People With Type 2 Diabetes. J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):2047-2053. doi: 10.1093/gerona/glab067. PMID: 33687062.
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J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):2047-2053. doi: 10.1093/gerona/glab067.

The Association Between Physical Activity Intensity, Cognition, and Brain Structure in People With Type 2 Diabetes.

The journals of gerontology. Series A, Biological sciences and medical sciences

Fateme Zabetian-Targhi, Velandai K Srikanth, Richard Beare, Monique Breslin, Chris Moran, Wei Wang, Feitong Wu, Kylie J Smith, Michele L Callisaya

Affiliations

  1. Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
  2. Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
  3. Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
  4. Department of Aged Care, Peninsula Health, Melbourne, Victoria, Australia.
  5. Cabrini Institute, Cabrini Health, Melbourne, Victoria, Australia.

PMID: 33687062 DOI: 10.1093/gerona/glab067

Abstract

BACKGROUND: Physical inactivity is a risk factor for type 2 diabetes (T2D) and dementia. However, it is unknown if physical activity (PA) intensity is associated with brain health in people with T2D. Therefore, this study aimed to determine (i) associations between PA intensity and step count with both cognition and brain structure and (ii) if apolipoprotein E-ε4 or insulin therapy modifies any associations.

METHODS: Participants were people with T2D (n = 220; aged 55-86 years). An accelerometer worn over the right hip was used to obtain step count and moderate-to-vigorous PA (MVPA) averaged over 7 days. Cognition in 7 domains was obtained using a battery of neuropsychological tests. Brain structure was measured by Magnetic Resonance Imaging. Linear regression models were used to examine associations between step count, MVPA and each cognitive and Magnetic Resonance Imaging measure. Apolipoprotein E-ε4 × PA and insulin therapy × PA product terms were added to the models to examine effect modification.

RESULTS: The mean age of participants was 67.9 (SD = 6.3). Higher step count was associated with greater hippocampal volume (β = 0.028, 95% CI = 0.005, 0.051). Insulin therapy modified the association between MVPA and attention-processing speed, such that associations were significant in people receiving insulin therapy (p for interaction = .019). There were no other significant associations.

CONCLUSIONS: Higher step count and greater time spent in MVPA may be associated with better hippocampal volume and attention-processing speed, respectively, in people with T2D. People with greater diabetes severity (receiving insulin therapy) may get more cognitive benefit from MVPA.

© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: Brain atrophy; Cognitive decline; Dementia; Physical activity intensity; Walking

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