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Byrne D, Nador RG, English JC, et al. Chronic Lung Allograft Dysfunction: Review of CT and Pathologic Findings. Radiol Cardiothorac Imaging. 2021;3(1):e200314doi: 10.1148/ryct.2021200314.
Byrne, D., Nador, R. G., English, J. C., Yee, J., Levy, R., Bergeron, C., Swiston, J. R., Mets, O. M., Muller, N. L., & Bilawich, A. M. (2021). Chronic Lung Allograft Dysfunction: Review of CT and Pathologic Findings. Radiology. Cardiothoracic imaging, 3(1), e200314. https://doi.org/10.1148/ryct.2021200314
Byrne, Danielle, et al. "Chronic Lung Allograft Dysfunction: Review of CT and Pathologic Findings." Radiology. Cardiothoracic imaging vol. 3,1 (2021): e200314. doi: https://doi.org/10.1148/ryct.2021200314
Byrne D, Nador RG, English JC, Yee J, Levy R, Bergeron C, Swiston JR, Mets OM, Muller NL, Bilawich AM. Chronic Lung Allograft Dysfunction: Review of CT and Pathologic Findings. Radiol Cardiothorac Imaging. 2021 Feb 11;3(1):e200314. doi: 10.1148/ryct.2021200314. eCollection 2021 Feb. PMID: 33778654; PMCID: PMC7978021.
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Radiol Cardiothorac Imaging. 2021 Feb 11;3(1):e200314. doi: 10.1148/ryct.2021200314. eCollection 2021 Feb.

Chronic Lung Allograft Dysfunction: Review of CT and Pathologic Findings.

Radiology. Cardiothoracic imaging

Danielle Byrne, Roland G Nador, John C English, John Yee, Robert Levy, Celine Bergeron, John R Swiston, Onno M Mets, Nestor L Muller, Ana-Maria Bilawich

Affiliations

  1. Department of Radiology, Division of Cardiothoracic Radiology (D.B., O.M.M., N.L.M., A.M.B.), Department of Medicine, Division of Respirology (R.G.N., R.D.L., C.B., J.R.S.), Department of Pathology (J.C.E.), and Department of Thoracic Surgery (J.Y.), Vancouver General Hospital, University of British Columbia, 899 W 12th Ave, Vancouver, BC, Canada V5Z 1L5; and British Columbia Lung Transplant Program, Vancouver, Canada (R.G.N., J.Y., R.D.L., C.B., J.R.S.).

PMID: 33778654 PMCID: PMC7978021 DOI: 10.1148/ryct.2021200314

Abstract

Chronic lung allograft dysfunction (CLAD) is the most common cause of mortality in lung transplant recipients after the 1st year of transplantation. CLAD has traditionally been classified into two distinct obstructive and restrictive forms: bronchiolitis obliterans syndrome and restrictive allograft syndrome. However, CLAD may manifest with a spectrum of imaging and pathologic findings and a combination of obstructive and restrictive physiologic abnormalities. Although the initial CT manifestations of CLAD may be nonspecific, the progression of findings at follow-up should signal the possibility of CLAD and may be present on imaging studies prior to the development of functional abnormalities of the lung allograft. This review encompasses the evolution of CT findings in CLAD, with emphasis on the underlying pathogenesis and pathologic condition, to enhance understanding of imaging findings. The purpose of this article is to familiarize the radiologist with the initial and follow-up CT findings of the obstructive, restrictive, and mixed forms of CLAD, for which early diagnosis and treatment may result in improved survival.

2021 by the Radiological Society of North America, Inc.

Conflict of interest statement

Disclosures of Conflicts of Interest: D.B. disclosed no relevant relationships. R.G.N. disclosed no relevant relationships. J.C.E. disclosed no relevant relationships. J.Y. disclosed no relevant relat

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