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Rahul E, Goel H, Chopra A, et al. An updated account on molecular heterogeneity of acute leukemia. Am J Blood Res. 2021;11(1):22-43
Rahul, E., Goel, H., Chopra, A., Ranjan, A., Gupta, A. K., Meena, J. P., Bakhshi, S., Misra, A., Hussain, S., Viswanathan, G. K., Rath, G. K., & Tanwar, P. (2021). An updated account on molecular heterogeneity of acute leukemia. American journal of blood research, 11(1), 22-43.
Rahul, Ekta, et al. "An updated account on molecular heterogeneity of acute leukemia." American journal of blood research vol. 11,1 (2021): 22-43.
Rahul E, Goel H, Chopra A, Ranjan A, Gupta AK, Meena JP, Bakhshi S, Misra A, Hussain S, Viswanathan GK, Rath GK, Tanwar P. An updated account on molecular heterogeneity of acute leukemia. Am J Blood Res. 2021 Feb 15;11(1):22-43. eCollection 2021. PMID: 33796387; PMCID: PMC8010602.
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Am J Blood Res. 2021 Feb 15;11(1):22-43. eCollection 2021.

An updated account on molecular heterogeneity of acute leukemia.

American journal of blood research

Ekta Rahul, Harsh Goel, Anita Chopra, Amar Ranjan, Aditya Kumar Gupta, Jagdish Prasad Meena, Sameer Bakhshi, Aroonima Misra, Showket Hussain, Ganesh Kumar Viswanathan, Goura Kishor Rath, Pranay Tanwar

Affiliations

  1. Laboratory Oncology Unit, Dr.B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences New Delhi 110029, India.
  2. Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi 110029, India.
  3. Department of Medical Oncology, Dr.B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences New Delhi 110029, India.
  4. National Institute of Pathology, ICMR New Delhi, India.
  5. Division of Molecular Oncology, National Institute of Cancer Prevention & Research I-7 Sector-39, Noida 201301, India.
  6. Department of Hematology, All India Institute of Medical Sciences New Delhi, India.
  7. Department of Radiotherapy, Dr.B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences New Delhi, India.

PMID: 33796387 PMCID: PMC8010602

Abstract

The progress in the field of personalized therapy has been the backbone for the improved mortality and morbidity figure in cancer especially with reference to acute leukemia. The same has been supported by evolving research and development in the field of genomics. The newer discoveries of mutations and the account of already discovered mutations have been playing a pivotal role to refine management strategy. Here, in this review, we are giving an account of relevant mutations and their potential role in the pathogenesis of acute leukemia. The article discusses the old and newly discovered mutations in acute myeloid/lymphoblastic leukemia. The various pathways and cross-talks between the mutations have been briefly described to develop insight towards their contributory and consequent role in the neoplastic process. The article is to sensitize the students, clinicians, and researchers towards the recent updates and development in genomics of acute leukemia.

AJBR Copyright © 2021.

Keywords: ALL; AML; genomics; mutations

Conflict of interest statement

None.

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