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J Invest Dermatol. 2021 Oct;141(10):2480-2489. doi: 10.1016/j.jid.2021.03.013. Epub 2021 Mar 30.

Melanoma Differentiation Trajectories Determine Sensitivity toward Pre-Existing CD8.

The Journal of investigative dermatology

Franziska Noelle Harbers, Beatrice Thier, Simone Stupia, Si Zhu, Marion Schwamborn, Vicky Peller, Heike Chauvistré, Pietro Crivello, Katharina Fleischhauer, Alexander Roesch, Antje Sucker, Dirk Schadendorf, Yong Chen, Annette Paschen, Fang Zhao

Affiliations

  1. Department of Dermatology, University Hospital Essen, University Duisburg-Essen and German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany.
  2. Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany.
  3. Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
  4. Department of Dermatology, University Hospital Essen, University Duisburg-Essen and German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Essen, Germany. Electronic address: [email protected].

PMID: 33798535 DOI: 10.1016/j.jid.2021.03.013

Abstract

The highly plastic nature of melanoma enables its transition among diverse cell states to survive hostile conditions. However, the interplay between specific tumor cell states and intratumoral T cells remains poorly defined. With MAPK inhibitor‒treated BRAF

Copyright © 2021 My employer is the owner of the copyright in the Article: University Hospital Essen, Essen, Germany. Published by Elsevier Inc. All rights reserved.

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