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Xu B, Tang B, Wei J. Role of STAT1 in the resistance of HBV to IFN-α. Exp Ther Med. 2021;21(6):550doi: 10.3892/etm.2021.9982.
Xu, B., Tang, B., & Wei, J. (2021). Role of STAT1 in the resistance of HBV to IFN-α. Experimental and therapeutic medicine, 21(6), 550. https://doi.org/10.3892/etm.2021.9982
Xu, Bingfa, et al. "Role of STAT1 in the resistance of HBV to IFN-α." Experimental and therapeutic medicine vol. 21,6 (2021): 550. doi: https://doi.org/10.3892/etm.2021.9982
Xu B, Tang B, Wei J. Role of STAT1 in the resistance of HBV to IFN-α. Exp Ther Med. 2021 Jun;21(6):550. doi: 10.3892/etm.2021.9982. Epub 2021 Mar 24. PMID: 33850522; PMCID: PMC8027746.
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Exp Ther Med. 2021 Jun;21(6):550. doi: 10.3892/etm.2021.9982. Epub 2021 Mar 24.

Role of STAT1 in the resistance of HBV to IFN-α.

Experimental and therapeutic medicine

Bingfa Xu, Bo Tang, Jiajia Wei

Affiliations

  1. Department of Pharmacy, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230061, P.R. China.
  2. Department of Pharmacy, Huainan First People's Hospital, Huainan, Anhui 232007, P.R. China.
  3. Department of Pharmacy, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China.

PMID: 33850522 PMCID: PMC8027746 DOI: 10.3892/etm.2021.9982

Abstract

The objective of the present study was to explore the mechanism of hepatitis B virus (HBV) resistance to interferon (IFN), and the role of signal transducer and activator of transcription 1 (STAT1). HepG2.2.15 cells were stimulated with a long-term (6-24 weeks) low-dose interferon (IFN)α-2b (10-70 IU/ml), so as to construct and screen a HepG2.2.15 cell model resistant to IFNα-2b. The changes of STAT1 and other proteins in the JAK-STAT signaling pathway, before and after drug resistance, were compared. The phosphorylation of STAT1 in HepG2.2.15 cells resistant to IFNα-2b was significantly decreased, and the expression level of 2',5'-oligoadenylate synthetase 1 was downregulated. Decreased phosphorylation of STAT1 in the JAK-STAT signaling pathway a contributor to the development of resistance to IFN-α in HBV.

Copyright: © Xu et al.

Keywords: Hepatitis B virus; drug resistance; interferon α-2b; phosphorylation; signal transducer and activator of transcription 1

Conflict of interest statement

The authors declare that they have no competing interests.

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