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Babiloni C, Arakaki X, Azami H, et al. Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel. Alzheimers Dement. 2021;17(9):1528-1553doi: 10.1002/alz.12311.
Babiloni, C., Arakaki, X., Azami, H., Bennys, K., Blinowska, K., Bonanni, L., Bujan, A., Carrillo, M. C., Cichocki, A., de Frutos-Lucas, J., Del Percio, C., Dubois, B., Edelmayer, R., Egan, G., Epelbaum, S., Escudero, J., Evans, A., Farina, F., Fargo, K., Fernández, A., Ferri, R., Frisoni, G., Hampel, H., Harrington, M. G., Jelic, V., Jeong, J., Jiang, Y., Kaminski, M., Kavcic, V., Kilborn, K., Kumar, S., Lam, A., Lim, L., Lizio, R., Lopez, D., Lopez, S., Lucey, B., Maestú, F., McGeown, W. J., McKeith, I., Moretti, D. V., Nobili, F., Noce, G., Olichney, J., Onofrj, M., Osorio, R., Parra-Rodriguez, M., Rajji, T., Ritter, P., Soricelli, A., Stocchi, F., Tarnanas, I., Taylor, J. P., Teipel, S., Tucci, F., Valdes-Sosa, M., Valdes-Sosa, P., Weiergräber, M., Yener, G., & Guntekin, B. (2021). Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(9), 1528-1553. https://doi.org/10.1002/alz.12311
Babiloni, Claudio, et al. "Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17,9 (2021): 1528-1553. doi: https://doi.org/10.1002/alz.12311
Babiloni C, Arakaki X, Azami H, Bennys K, Blinowska K, Bonanni L, Bujan A, Carrillo MC, Cichocki A, de Frutos-Lucas J, Del Percio C, Dubois B, Edelmayer R, Egan G, Epelbaum S, Escudero J, Evans A, Farina F, Fargo K, Fernández A, Ferri R, Frisoni G, Hampel H, Harrington MG, Jelic V, Jeong J, Jiang Y, Kaminski M, Kavcic V, Kilborn K, Kumar S, Lam A, Lim L, Lizio R, Lopez D, Lopez S, Lucey B, Maestú F, McGeown WJ, McKeith I, Moretti DV, Nobili F, Noce G, Olichney J, Onofrj M, Osorio R, Parra-Rodriguez M, Rajji T, Ritter P, Soricelli A, Stocchi F, Tarnanas I, Taylor JP, Teipel S, Tucci F, Valdes-Sosa M, Valdes-Sosa P, Weiergräber M, Yener G, Guntekin B. Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel. Alzheimers Dement. 2021 Sep;17(9):1528-1553. doi: 10.1002/alz.12311. Epub 2021 Apr 15. PMID: 33860614; PMCID: PMC8647863.
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Alzheimers Dement. 2021 Sep;17(9):1528-1553. doi: 10.1002/alz.12311. Epub 2021 Apr 15.

Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Claudio Babiloni, Xianghong Arakaki, Hamed Azami, Karim Bennys, Katarzyna Blinowska, Laura Bonanni, Ana Bujan, Maria C Carrillo, Andrzej Cichocki, Jaisalmer de Frutos-Lucas, Claudio Del Percio, Bruno Dubois, Rebecca Edelmayer, Gary Egan, Stephane Epelbaum, Javier Escudero, Alan Evans, Francesca Farina, Keith Fargo, Alberto Fernández, Raffaele Ferri, Giovanni Frisoni, Harald Hampel, Michael G Harrington, Vesna Jelic, Jaeseung Jeong, Yang Jiang, Maciej Kaminski, Voyko Kavcic, Kerry Kilborn, Sanjeev Kumar, Alice Lam, Lew Lim, Roberta Lizio, David Lopez, Susanna Lopez, Brendan Lucey, Fernando Maestú, William J McGeown, Ian McKeith, Davide Vito Moretti, Flavio Nobili, Giuseppe Noce, John Olichney, Marco Onofrj, Ricardo Osorio, Mario Parra-Rodriguez, Tarek Rajji, Petra Ritter, Andrea Soricelli, Fabrizio Stocchi, Ioannis Tarnanas, John Paul Taylor, Stefan Teipel, Federico Tucci, Mitchell Valdes-Sosa, Pedro Valdes-Sosa, Marco Weiergräber, Gorsev Yener, Bahar Guntekin

Affiliations

  1. Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy.
  2. San Raffaele of Cassino, Cassino (FR), Italy.
  3. Huntington Medical Research Institutes, Pasadena, California, USA.
  4. Department of Neurology and Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  5. Centre Mémoire de Ressources et de Recherche (CMRR), Centre Hospitalier, Universitaire de Montpellier, Montpellier, France.
  6. Institute of Biocybernetics, Warsaw, Poland.
  7. Faculty of Physics University of Warsaw and Nalecz, Warsaw, Poland.
  8. Department of Neuroscience Imaging and Clinical Sciences and CESI, University "G. D'Annunzio" of Chieti-Pescara, Chieti, Italy.
  9. Psychological Neuroscience Lab, School of Psychology, University of Minho, Minho, Portugal.
  10. Division of Medical & Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA.
  11. Skolkowo Institute of Science and Technology (SKOLTECH), Moscow, Russia.
  12. Systems Research Institute PAS, Warsaw, Poland.
  13. Nicolaus Copernicus University (UMK), Torun, Poland.
  14. Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Complutense and Universidad Politécnica de Madrid, Madrid, Spain.
  15. Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Boulevard de l'hôpital, Institute of Memory and Alzheimer's Disease (IM2A), Paris, France.
  16. ICM, INSERM U1127, CNRS UMR 7225, Sorbonne Université, Institut du Cerveau et de la Moelle épinière, Paris, France.
  17. Foundation Director of the Monash Biomedical Imaging (MBI) Research Facilities, Monash University, Clayton, Australia.
  18. School of Engineering, Institute for Digital Communications, The University of Edinburgh, Edinburgh, UK.
  19. Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
  20. Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
  21. Oasi Research Institute - IRCCS, Troina, Italy.
  22. IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
  23. Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
  24. GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, Sorbonne University, Paris, France.
  25. Division of Clinical Geriatrics, NVS Department, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
  26. Department of Bio and Brain Engineering/Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.
  27. Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
  28. Institute of Gerontology, Wayne State University, Detroit, Michigan, USA.
  29. School of Psychology, University of Glasgow, Glasgow, UK.
  30. Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  31. MGH Epilepsy Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  32. Vielight Inc., Toronto, Ontario, Canada.
  33. IRCCS SDN, Napoli, Italy.
  34. Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
  35. School of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK.
  36. Newcastle upon Tyne, Translational and Clinical Research Institute, Newcastle University, UK.
  37. Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
  38. Clinica Neurologica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  39. UC Davis Department of Neurology and Center for Mind and Brain, Davis, California, USA.
  40. Center for Brain Health, Department of Psychiatry, NYU Langone Medical Center, New York, New York, USA.
  41. Brain Simulation Section, Department of Neurology, Charité Universitätsmedizin and Berlin Institute of Health, Berlin, Germany.
  42. Bernstein Center for Computational Neuroscience, Berlin, Germany.
  43. Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy.
  44. IRCCS San Raffaele Pisana, Rome, Italy.
  45. Global Brain Health Institute, University of California San Francisco, San Francisco, USA.
  46. Global Brain Health Institute, Trinity College Dublin, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
  47. Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany.
  48. German Center for Neurodegenerative Diseases (DZNE) - Rostock/Greifswald, Rostock, Germany.
  49. Cuban Neuroscience Center, Havana, Cuba.
  50. Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
  51. Experimental Neuropsychopharmacology, BfArM), Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, Bonn, Germany.
  52. Departments of Neurosciences and Department of Neurology, Dokuz Eylül University Medical School, Izmir, Turkey.
  53. Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
  54. REMER, Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Turkey.

PMID: 33860614 PMCID: PMC8647863 DOI: 10.1002/alz.12311

Abstract

The Electrophysiology Professional Interest Area (EPIA) and Global Brain Consortium endorsed recommendations on candidate electroencephalography (EEG) measures for Alzheimer's disease (AD) clinical trials. The Panel reviewed the field literature. As most consistent findings, AD patients with mild cognitive impairment and dementia showed abnormalities in peak frequency, power, and "interrelatedness" at posterior alpha (8-12 Hz) and widespread delta (< 4 Hz) and theta (4-8 Hz) rhythms in relation to disease progression and interventions. The following consensus statements were subscribed: (1) Standardization of instructions to patients, resting state EEG (rsEEG) recording methods, and selection of artifact-free rsEEG periods are needed; (2) power density and "interrelatedness" rsEEG measures (e.g., directed transfer function, phase lag index, linear lagged connectivity, etc.) at delta, theta, and alpha frequency bands may be use for stratification of AD patients and monitoring of disease progression and intervention; and (3) international multisectoral initiatives are mandatory for regulatory purposes.

© 2021 the Alzheimer's Association.

Keywords: Alzheimer's disease; The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART); biomarkers; clinical trials; dementia; electroencephalography (EEG); eyes-closed resting state condition

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