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Sainz J, García-Verdejo FJ, Martínez-Bueno M, et al. Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts. Cancers (Basel). 2021;13(6)doi: 10.3390/cancers13061258.
Sainz, J., García-Verdejo, F. J., Martínez-Bueno, M., Kumar, A., Sánchez-Maldonado, J. M., Díez-Villanueva, A., Vodičková, L., Vymetálková, V., Martin Sánchez, V., Da Silva Filho, M. I., Sampaio-Marques, B., Brezina, S., Butterbach, K., Ter Horst, R., Hoffmeister, M., Ludovico, P., Jurado, M., Li, Y., Sánchez-Rovira, P., Netea, M. G., Gsur, A., Vodička, P., Moreno, V., Hemminki, K., Brenner, H., Chang-Claude, J., & Försti, A. (2021). Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts. Cancers, 13(6), . https://doi.org/10.3390/cancers13061258
Sainz, Juan, et al. "Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts." Cancers vol. 13,6 (2021). doi: https://doi.org/10.3390/cancers13061258
Sainz J, García-Verdejo FJ, Martínez-Bueno M, Kumar A, Sánchez-Maldonado JM, Díez-Villanueva A, Vodičková L, Vymetálková V, Martin Sánchez V, Da Silva Filho MI, Sampaio-Marques B, Brezina S, Butterbach K, Ter Horst R, Hoffmeister M, Ludovico P, Jurado M, Li Y, Sánchez-Rovira P, Netea MG, Gsur A, Vodička P, Moreno V, Hemminki K, Brenner H, Chang-Claude J, Försti A. Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts. Cancers (Basel). 2021 Mar 12;13(6). doi: 10.3390/cancers13061258. PMID: 33809172; PMCID: PMC7998818.
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Cancers (Basel). 2021 Mar 12;13(6). doi: 10.3390/cancers13061258.

Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts.

Cancers

Juan Sainz, Francisco José García-Verdejo, Manuel Martínez-Bueno, Abhishek Kumar, José Manuel Sánchez-Maldonado, Anna Díez-Villanueva, Ludmila Vodičková, Veronika Vymetálková, Vicente Martin Sánchez, Miguel Inacio Da Silva Filho, Belém Sampaio-Marques, Stefanie Brezina, Katja Butterbach, Rob Ter Horst, Michael Hoffmeister, Paula Ludovico, Manuel Jurado, Yang Li, Pedro Sánchez-Rovira, Mihai G Netea, Andrea Gsur, Pavel Vodička, Víctor Moreno, Kari Hemminki, Hermann Brenner, Jenny Chang-Claude, Asta Försti

Affiliations

  1. Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain.
  2. Hematology Department, Virgen de las Nieves University Hospital, 18012 Granada, Spain.
  3. Instituto de Investigación Biosanataria IBs.Granada, 18012 Granada, Spain.
  4. Department of Medicine, University of Granada, 18016 Granada, Spain.
  5. Department of Medical Oncology, Complejo Hospitalario de Jaén, 23007 Jaén, Spain.
  6. Area of Genomic Medicine, GENYO, Centre for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain.
  7. Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  8. Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka 560066, India.
  9. Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.
  10. Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) and University of Barcelona, 08908 Barcelona, Spain.
  11. Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 00 Prague, Czech Republic.
  12. Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, 12800 Prague, Czech Republic.
  13. Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, 323 00 Pilsen, Czech Republic.
  14. Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain.
  15. Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain.
  16. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.
  17. ICVS/3B's-PT Government Associate Laboratory, Braga, Guimarães, Portugal.
  18. Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.
  19. Network Aging Research (NAR), University of Heidelberg, 69115 Heidelberg, Germany.
  20. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, The Netherlands.
  21. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
  22. Centre for Individualised Infection Medicine (CiiM) & TWINCORE, Joint Ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), 30625 Hannover, Germany.
  23. Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
  24. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
  25. Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, 30605 Pilsen, Czech Republic.
  26. Division of Preventive Oncology, German Cancer Research Center (DKFZ), National Center for Tumour Diseases (NCT), 69120 Heidelberg, Germany.
  27. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  28. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  29. Genetic Tumour Epidemiology Group, University Medical Center Hamburg-Eppendorf, University Cancer Center, 20246 Hamburg, Germany.
  30. Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
  31. Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.

PMID: 33809172 PMCID: PMC7998818 DOI: 10.3390/cancers13061258

Abstract

The role of genetic variation in autophagy-related genes in modulating autophagy and cancer is poorly understood. Here, we comprehensively investigated the association of autophagy-related variants with colorectal cancer (CRC) risk and provide new insights about the molecular mechanisms underlying the associations. After meta-analysis of the genome-wide association study (GWAS) data from four independent European cohorts (8006 CRC cases and 7070 controls), two loci,

Keywords: autophagy; colorectal cancer; genetic variants; susceptibility

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