Display options
Share it on

Acta Anaesthesiol Scand. 2021 Sep;65(8):1073-1078. doi: 10.1111/aas.13828. Epub 2021 Jul 27.

Prevalence and impact of hazardous alcohol use in intensive care cohort: A multicenter, register-based study.

Acta anaesthesiologica Scandinavica

Eliisa Nissilä, Marja Hynninen, Matti Reinikainen, Stepani Bendel, Raili Suojaranta, Anna-Maija Korhonen, Markku Suvela, Pekka Loisa, Tadeusz Kaminski, Johanna Hästbacka

Affiliations

  1. Department of Anaesthesiology, Intensive Care and Pain Medicine, Intensive Care Units, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
  2. Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland.
  3. Department of Cardiac Surgery, Heart and Lung Center, University of Helsinki, Helsinki University Hospital Helsinki University Hospital, Helsinki, Finland.
  4. Intensive Care Unit, North Karelia Central Hospital, Joensuu, Finland.
  5. Intensive Care Unit, Päijät-Häme Central Hospital, Lahti, Finland.
  6. Intensive Care Unit, Central Ostrobothnia Central Hospital, Kokkola, Finland.

PMID: 33840090 DOI: 10.1111/aas.13828

Abstract

BACKGROUND: Reports of the prevalence and impact of hazardous alcohol use among intensive care unit (ICU) patients are contradictory. We aimed to study the prevalence of hazardous alcohol use among ICU patients and its association with ICU length of stay (LOS) and mortality.

METHODS: Finnish ICUs have been using the Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) to evaluate and record patients' alcohol use into the Finnish Intensive Care Consortium's Database (FICC). We retrieved data from the FICC from a 3-month period. We excluded data from centers with an AUDIT-C recording rate of less than 70% of admissions. We defined hazardous alcohol use as a score of 5 or more for women and 6 or more for men from a maximum score of 12 points.

RESULTS: Two thousand forty-five patients were treated in the 10 centers with an AUDIT-C recording rate of 70% or higher. AUDIT-C was available for 1576 (77%) patients and indicated hazardous alcohol use for 334 (21%) patients who were more often younger (median age 55 [interquartile range 42-65] vs 67 [57-74] [P < .001]) and male (78.1% vs 61.3% [P < .001]) compared to other patients. We found no difference in LOS or hospital mortality between hazardous and non-hazardous alcohol users. Among the non-abstinent, risk of death within a year increased with increasing AUDIT-C scores adjusted odds ratio 1.077 (95% confidence interval, 1.006-1.152) per point.

CONCLUSION: The prevalence of hazardous alcohol use in Finnish ICUs was 21%. Patients with hazardous alcohol use were more often younger and male compared with non-hazardous alcohol users.

© 2021 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Keywords: AUDIT-C; hazardous alcohol use; intensive care unit; mortality; prevalence

References

  1. GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the global burden of disease study 2016. Lancet. 2018;392(10152):1015-1035. - PubMed
  2. Christensen S, Johansen MB, Pedersen L, et al. Three-year mortality among alcoholic patients after intensive care: a population-based cohort study. Crit Care. 2012;16:R5. - PubMed
  3. Geary T, O'Brien P, Ramsay S, Cook B, Scottish Intensive Care Trainees' Audit Share Group. A national service evaluation of the impact of alcohol on admissions to Scottish intensive care units. Anaesthesia. 2012;67:1132-1137. - PubMed
  4. Larkin CM, Fagan C. Significant reduction in alcohol-related admissions to an intensive care unit in Dublin. Ir J Med Sci. 2015;184:697-700. - PubMed
  5. McKenny M, O'Beirne S, Fagan C, O'Connell M. Alcohol-related admissions to an intensive care unit in Dublin. Ir J Med Sci. 2010;179:405-408. - PubMed
  6. Mostafa SM, Murthy BV. Alcohol-associated admissions to an adult intensive care unit: an audit. Eur J Anaesthesiol. 2002;19:193-196. - PubMed
  7. Uusaro A, Parviainen I, Tenhunen JJ, Ruokonen E. The proportion of intensive care unit admissions related to alcohol use: a prospective cohort study. Acta Anaesthesiol Scand. 2005;49:1236-1240. - PubMed
  8. McPeake J, Bateson M, O'Neill A, Kinsella J. Assessment and management of alcohol-related admissions to UK intensive care units. Nurs Crit Care. 2013;18:187-192. - PubMed
  9. Gacouin A, Tadie JM, Uhel F, et al. At-risk drinking is independently associated with ICU and one-year mortality in critically ill nontrauma patients*. Crit Care Med. 2014;42:860-867. - PubMed
  10. Tollisen KH, Bjerva M, Hadley CL, et al. Substance abuse-related admissions in a mixed Norwegian intensive care population. Acta Anaesthesiol Scand. 2020;64:329-337. - PubMed
  11. Secombe P, Campbell L, Brown A, Bailey M, Pilcher D. Alcohol misuse and critical care admissions in the Northern Territory. Intern Med J. 2021. https://doi.org/10.1111/imj.15212 - PubMed
  12. Gacouin A, Legay F, Camus C, et al. At-risk drinkers are at higher risk to acquire a bacterial infection during an intensive care unit stay than abstinent or moderate drinkers. Crit Care Med. 2008;36:1735-1741. - PubMed
  13. Simou E, Leonardi-Bee J, Britton J. The effect of alcohol consumption on the risk of ARDS: a systematic review and meta-analysis. Chest. 2018;154:58-68. - PubMed
  14. McPeake JM, Shaw M, O'Neill A,et al. Do alcohol use disorders impact on long term outcomes from intensive care? Crit Care. 2015;19:185-186. - PubMed
  15. Saunders JB, Degenhardt L, Reed GM, Poznyak V. Alcohol use disorders in ICD-11: past, present, and future. Alcohol Clin Exp Res. 2019;43:1617-1631. - PubMed
  16. Aalto M, Alho H, Halme JT, Seppa K. AUDIT and its abbreviated versions in detecting heavy and binge drinking in a general population survey. Drug Alcohol Depend. 2009;103:25-29. - PubMed
  17. Aalto M, Tuunanen M, Sillanaukee P, Seppa K. Effectiveness of structured questionnaires for screening heavy drinking in middle-aged women. Alcohol Clin Exp Res. 2006;30:1884-1888. - PubMed
  18. Tuunanen M, Aalto M, Seppa K. Binge drinking and its detection among middle-aged men using AUDIT, AUDIT-C and AUDIT-3. Drug Alcohol Rev. 2007;26:295-299. - PubMed
  19. Reinikainen M, Mussalo P, Hovilehto S, et al. Association of automated data collection and data completeness with outcomes of intensive care. A new customised model for outcome prediction. Acta Anaesthesiol Scand. 2012;56:1114-1122. - PubMed
  20. Le Gall JR, Lemeshow S, Saulnier F. A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA. 2029;270:2957-2963. - PubMed
  21. Vincent JL, de Mendonca A, Cantraine F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med. 1998;26:1793-1800. - PubMed
  22. Moreno R, Morais P. Validation of the simplified therapeutic intervention scoring system on an independent database. Intensive Care Med. 1997;23:640-644. - PubMed
  23. Mäkelä P, Härkönen J, Lintonen T, Tigerstedt C, Warpenius K. Näin Suomi juo-Suomalaisten muuttuvat alkoholinkäyttötavat. The National Institute for Health and Welfare. http://urn.fi/URN:ISBN:978-952-343-146-1. Accessed 2018 - PubMed
  24. Uljas E, Jalkanen V, Kuitunen A, Hynninen M, Hastbacka J. Prevalence of risk-drinking in critically ill patients, screened with carbohydrate-deficient transferrin and AUDIT-C score: A retrospective study. Acta Anaesthesiol Scand. 2020;64(2):216-223. - PubMed
  25. Halme JT, Seppa K, Alho H, et al. Hazardous drinking: prevalence and associations in the Finnish general population. Alcohol Clin Exp Res. 2008;32:1615-1622. - PubMed
  26. Stockwell T, Zhao J, Panwar S, Roemer A, Naimi T, Chikritzhs T. Do, "moderate" drinkers have reduced mortality risk? A systematic review and meta-analysis of alcohol consumption and all-cause mortality. J Stud Alcohol Drugs. 2016;77:185-198. - PubMed
  27. Hietanen S, Ala-Kokko T, Ohtonen P, Kakela R, Niemela S, Liisanantti JH. Treatment profile and 1-year mortality among nontraumatic intensive care unit patients with alcohol-related health problems. J Intensive Care Med. 2020;35:244-250. - PubMed
  28. Connors GJ, Maisto SA. Drinking reports from collateral individuals. Addiction. 2003;98(Suppl 2):21-29. - PubMed

MeSH terms

Publication Types

Grant support