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Chen J, Liu J, Huang Y, et al. Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition. Drug Metab Rev. 2021;53(4):491-507doi: 10.1080/03602532.2021.1917598.
Chen, J., Liu, J., Huang, Y., Li, R., Ma, C., Zhang, B., Wu, F., Yu, W., Zuo, X., Liang, Y., & Wang, Q. (2021). Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition. Drug metabolism reviews, 53(4), 491-507. https://doi.org/10.1080/03602532.2021.1917598
Chen, Junmei, et al. "Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition." Drug metabolism reviews vol. 53,4 (2021): 491-507. doi: https://doi.org/10.1080/03602532.2021.1917598
Chen J, Liu J, Huang Y, Li R, Ma C, Zhang B, Wu F, Yu W, Zuo X, Liang Y, Wang Q. Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition. Drug Metab Rev. 2021 Nov;53(4):491-507. doi: 10.1080/03602532.2021.1917598. Epub 2021 Apr 27. PMID: 33905669.
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Drug Metab Rev. 2021 Nov;53(4):491-507. doi: 10.1080/03602532.2021.1917598. Epub 2021 Apr 27.

Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition.

Drug metabolism reviews

Junmei Chen, Jinman Liu, Yueyue Huang, Ruoyu Li, Cuiru Ma, Beiping Zhang, Fanchang Wu, Wenqian Yu, Xue Zuo, Yong Liang, Qi Wang

Affiliations

  1. Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
  2. Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China.
  3. Department of Gastroenterology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

PMID: 33905669 DOI: 10.1080/03602532.2021.1917598

Abstract

Herbal plants typically have complex compositions and diverse mechanisms. Among them, bioactive constituents with relatively high exposure

Keywords: CYP3A; bioavailability; herbal medicine; inhibition; therapeutic constituents

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