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Bargnoux AS, Kuster N, Sutra T, et al. Evaluation of a new point-of-care testing for creatinine and urea measurement. Scand J Clin Lab Invest. 2021;81(4):290-297doi: 10.1080/00365513.2021.1914344.
Bargnoux, A. S., Kuster, N., Sutra, T., Laroche, L., Rodriguez, A., Morena, M., Chenine, L., Chalabi, L., Dupuy, A. M., Badiou, S., & Cristol, J. P. (2021). Evaluation of a new point-of-care testing for creatinine and urea measurement. Scandinavian journal of clinical and laboratory investigation, 81(4), 290-297. https://doi.org/10.1080/00365513.2021.1914344
Bargnoux, Anne-Sophie, et al. "Evaluation of a new point-of-care testing for creatinine and urea measurement." Scandinavian journal of clinical and laboratory investigation vol. 81,4 (2021): 290-297. doi: https://doi.org/10.1080/00365513.2021.1914344
Bargnoux AS, Kuster N, Sutra T, Laroche L, Rodriguez A, Morena M, Chenine L, Chalabi L, Dupuy AM, Badiou S, Cristol JP. Evaluation of a new point-of-care testing for creatinine and urea measurement. Scand J Clin Lab Invest. 2021 Jul;81(4):290-297. doi: 10.1080/00365513.2021.1914344. Epub 2021 Apr 28. PMID: 33908840.
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Scand J Clin Lab Invest. 2021 Jul;81(4):290-297. doi: 10.1080/00365513.2021.1914344. Epub 2021 Apr 28.

Evaluation of a new point-of-care testing for creatinine and urea measurement.

Scandinavian journal of clinical and laboratory investigation

Anne-Sophie Bargnoux, Nils Kuster, Thibault Sutra, Laëtitia Laroche, Annie Rodriguez, Marion Morena, Leila Chenine, Lotfi Chalabi, Anne-Marie Dupuy, Stéphanie Badiou, Jean-Paul Cristol

Affiliations

  1. Département de Biochimie et Hormonologie, PhyMedExp, INSERM, CNRS, CHU de Montpellier, Université de Montpellier, Montpellier, France.
  2. Département de Biochimie et Hormonologie, CHU de Montpellier, Université de Montpellier, Montpellier, France.
  3. Département de Néphrologie, Dialyse et Transplantation, CHU de Montpellier, Université de Montpellier, Montpellier, France.
  4. AIDER, Montpellier, France.

PMID: 33908840 DOI: 10.1080/00365513.2021.1914344

Abstract

Point of care testing makes it possible to obtain results in an extremely short time. Recently, radiometer has expanded the panel of tests available on its ABL90 FLEX PLUS blood gas analyzer (ABL90) by adding urea and creatinine. The aim of this study was to verify the performance of these new parameters. This included assessment of imprecision, linearity, accuracy by comparison with central laboratory standard assays and interferences. In addition, clinical utility in a dialysis center was evaluated. Within-lab coefficients of variation were close to 2%. The mean and limits of agreement (mean ± 1.96 SD) of the difference between ABL90 and Roche enzymatic assays on cobas 8000 were 0.5 (from -1.4 to 2.3) mmol/L and -0.9 (from -19.5 to 17.8) µmol/L for urea and creatinine, respectively. The ABL90 enzymatic urea and creatinine assays met the acceptance criteria based on biological variation for imprecision and showed good agreement with central laboratory. The two assays were unaffected by hematocrit variation between 20 and 70%, hemolysis and icterus interferences. It should be noted that the relationship between lab methods and ABL90 was conserved even for high pre-dialysis values allowing easy access to dialysis adequacy parameters (

Keywords: Creatinine; analytical performances; interferences; point-of-care testing; urea

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