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Shen X, Cao K, Zhao Y, et al. Targeting Neutrophils in Sepsis: From Mechanism to Translation. Front Pharmacol. 2021;12:644270doi: 10.3389/fphar.2021.644270.
Shen, X., Cao, K., Zhao, Y., & Du, J. (2021). Targeting Neutrophils in Sepsis: From Mechanism to Translation. Frontiers in pharmacology, 12644270. https://doi.org/10.3389/fphar.2021.644270
Shen, Xiaofei, et al. "Targeting Neutrophils in Sepsis: From Mechanism to Translation." Frontiers in pharmacology vol. 12 (2021): 644270. doi: https://doi.org/10.3389/fphar.2021.644270
Shen X, Cao K, Zhao Y, Du J. Targeting Neutrophils in Sepsis: From Mechanism to Translation. Front Pharmacol. 2021 Apr 12;12:644270. doi: 10.3389/fphar.2021.644270. eCollection 2021. PMID: 33912055; PMCID: PMC8072352.
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Front Pharmacol. 2021 Apr 12;12:644270. doi: 10.3389/fphar.2021.644270. eCollection 2021.

Targeting Neutrophils in Sepsis: From Mechanism to Translation.

Frontiers in pharmacology

Xiaofei Shen, Ke Cao, Yang Zhao, Junfeng Du

Affiliations

  1. Faculty of Hepato-Biliary-Pancreatic Surgery, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
  2. Department of Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
  3. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  4. Medical Department of General Surgery, The 1st Medical Center of Chinese PLA General Hospital, Beijing, China.
  5. Department of General Surgery, The 7th Medical Center, Chinese PLA General Hospital, Beijing, China.
  6. The Second School of Clinical Medicine, Southern Medical University, Guangdong, China.

PMID: 33912055 PMCID: PMC8072352 DOI: 10.3389/fphar.2021.644270

Abstract

Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Although our understanding in the pathophysiological features of sepsis has increased significantly during the past decades, there is still lack of specific treatment for sepsis. Neutrophils are important regulators against invading pathogens, and their role during sepsis has been studied extensively. It has been suggested that the migration, the antimicrobial activity, and the function of neutrophil extracellular traps (NETs) have all been impaired during sepsis, which results in an inappropriate response to primary infection and potentially increase the susceptibility to secondary infection. On the other hand, accumulating evidence has shown that the reversal or restoration of neutrophil function can promote bacterial clearance and improve sepsis outcome, supporting the idea that targeting neutrophils may be a promising strategy for sepsis treatment. In this review, we will give an overview of the role of neutrophils during sepsis and discuss the potential therapeutic strategy targeting neutrophils.

Copyright © 2021 Shen, Cao, Zhao and Du.

Keywords: Signaling pathway; neutrophil; sepsis; therapeutic target; translational medicine

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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